INT101365

Context Info Confidence 0.11 First Reported 2002 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 8 Total Number 10 Disease Relevance 1.66 Pain Relevance 0.49

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1) cytoplasm (Tjp1)

Anatomy Link Frequency tail 2 Fundus 1 Tjp1 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 2 98.52 Kinase C 6 97.44 Root ganglion neuron 1 91.68 agonist 3 87.84 tissue acidosis 1 87.84 ASIC 1 76.32 dorsal root ganglion 1 71.12 Inflammatory mediators 2 47.12 Central nervous system 6 27.52 Neurobehavioral 2 10.92

Disease Link Frequency Relevance Heat Pain 2 98.52 Ganglion Cysts 80 91.36 Cancer 54 89.68 Acidosis 1 87.84 Apoptosis 175 87.60 Death 12 83.12 Congenital Anomalies 12 82.12 Diabetic Angiopathy 6 73.48 Nociception 1 62.72 Metastasis 50 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, binding of zo-1 to the COOH-terminal cytoplasmic tail of occludin plays a role in maintaining the tight junction and also cytoskeletal tethering [48], whereas previous studies describe the association of occludin/zo-1 as dependent upon both tyrosine phosphatase signaling and also protein kinase C [49].

zo-1 Binding (association) of in tail associated with kinase c

1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.38 Pain Relevance 0.05

In concordance with these observations in vivo, coculture of ECs and 10T1/2 cells led to enhanced EC barrier function, and the addition of the ALK5 inhibitor reversed this effect and reduced coculture-induced association between occludin and zo-1.

zo-1 Binding (association) of

2) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.25 Pain Relevance 0

Immunoprecipitation of occludin followed by western blotting for zo-1 revealed that coculture of EC with 10T1/2 cells led to an increased association between occludin and zo-1 in EC, which was significantly reduced by TGF-?

zo-1 Binding (association) of

3) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.05 Pain Relevance 0

For example, binding of zo-1 to the COOH-terminal cytoplasmic tail of occludin plays a role in maintaining the tight junction and also cytoskeletal tethering [48], whereas previous studies describe the association of occludin/zo-1 as dependent upon both tyrosine phosphatase signaling and also protein kinase C [49].

zo-1 Binding (binding) of in tail associated with kinase c

4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.26 Pain Relevance 0.04

Fundus angiography and Evans blue permeability assay revealed a breakdown of the blood-retinal-barrier that was characterized by decreased association between the tight junction proteins zo-1 and occludin.

zo-1 Binding (association) of in Fundus

5) Confidence 0.07 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2659748 Disease Relevance 0.17 Pain Relevance 0

Changes in occludin/zo-1 co-association were monitored by immunoprecipitation, performed as previously described [53] with minor modifications.

zo-1 Binding (association) of

6) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0 Pain Relevance 0

The enhanced interaction between ZO-1 and occludin appeared to be most pronounced in cerebral microvessels of PCB126-treated animals, followed by the PCB153 treatment group.

ZO-1 Spec (appeared) Binding (interaction) of

7) Confidence 0.07 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0 Pain Relevance 0

Exposure to PCB118 and PCB153 modulated expressional levels of claudin-5 and ZO-1, whereas PCB126 appeared to primarily influence the coassociation of occludin and ZO-1.

ZO-1 Spec (appeared) Binding (coassociation) of

8) Confidence 0.07 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0.06 Pain Relevance 0.04

Interestingly, some internalized dextran at MCJs colocalizes with internalized E-cadherin as well as ZO-1, a scaffolding protein associated with the TJs in polarized cells (Figure 3E) [70].

ZO-1 Binding (associated) of

9) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0 Pain Relevance 0

We report here the interaction of this channel subunit with the multivalent PDZ (PSD-95 Drosophila discs-large protein, Zonula occludens protein 1) domain-containing protein CIPP.

Zonula occludens protein 1 Binding (interaction) of

10) Confidence 0.02 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.50 Pain Relevance 0.35

General Comments

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