INT101370

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Context Info
Confidence 0.00
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CNGB3) transport (CNGB3)
Anatomy Link Frequency
sensory neurons 1
CNGB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 54 98.34 Very High Very High Very High
ASIC 1 98.08 Very High Very High Very High
Pain 16 88.24 High High
tissue acidosis 1 86.96 High High
Root ganglion neuron 1 83.36 Quite High
dorsal root ganglion 1 54.68 Quite High
Dorsal horn 2 23.04 Low Low
Central nervous system 1 21.76 Low Low
substance P 13 16.36 Low Low
cytokine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 13 88.24 High High
Acidosis 1 86.68 High High
Ganglion Cysts 2 83.16 Quite High
Nociception 7 63.84 Quite High
Disease 10 41.28 Quite Low
Intervertebral Disk Degeneration 4 38.00 Quite Low
Low Back Pain 5 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, studies by Uchiyama and colleagues have highlighted a role for NGF in adaptation of disc cells to their acidic and hyperosmotic microenvironment via regulation of acid-sensing ion channel 3 [30].
Regulation (regulation) of channel 3 associated with nerve growth factor
1) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.13 Pain Relevance 0.39
The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons.
Regulation (partner) of channel 3 in sensory neurons
2) Confidence 0.00 Published 2002 Journal J. Biol. Chem. Section Title Doc Link 11872753 Disease Relevance 0.44 Pain Relevance 0.33

General Comments

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