INT10138

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.57
Pain Relevance 4.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
plasma 2
nociceptors 2
urine 2
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 94 100.00 Very High Very High Very High
substance P 1 99.92 Very High Very High Very High
nociceptor 2 99.60 Very High Very High Very High
Pain threshold 14 98.32 Very High Very High Very High
Inflammation 89 96.44 Very High Very High Very High
Analgesic 18 95.56 Very High Very High Very High
Pain 118 93.16 High High
cytokine 6 92.72 High High
cINOD 68 92.12 High High
Glutamate 3 89.32 High High
Disease Link Frequency Relevance Heat
Weight Loss 43 100.00 Very High Very High Very High
Glaucoma 40 99.84 Very High Very High Very High
Gastrointestinal Neoplasms 2 99.28 Very High Very High Very High
Pressure And Volume Under Development 85 99.04 Very High Very High Very High
Hyperalgesia 7 99.00 Very High Very High Very High
Edema 52 98.96 Very High Very High Very High
Ovarian Cancer 58 98.76 Very High Very High Very High
Pain 132 98.32 Very High Very High Very High
Breast Cancer 2 98.08 Very High Very High Very High
Nociception 2 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies performed on serum and plasma samples have shown that the expression of kininogen-1 was significantly reduced in patients with gastrointestinal cancer [21], breast cancer [22] and two different types of cervical cancer [23].
Negative_regulation (reduced) of Gene_expression (expression) of kininogen-1 in plasma associated with cervical cancer, breast cancer and gastrointestinal neoplasms
1) Confidence 0.57 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 1.00 Pain Relevance 0
In view of these previous reports, it was not surprising to find similar reduced levels of kininogen-1 in the urine of patients with ovarian carcinoma in this study.
Negative_regulation (reduced) of Gene_expression (levels) of kininogen-1 in urine associated with ovarian cancer
2) Confidence 0.41 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 1.30 Pain Relevance 0.16
Ecallantide inhibits kallikrein, thus reducing bradykinin production and preventing further swelling.51 It is currently unlicensed.
Negative_regulation (reducing) of Gene_expression (production) of bradykinin associated with pressure and volume under development and bradykinin
3) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941790 Disease Relevance 0.91 Pain Relevance 0.13
Since icatibant does not replace C1 inhibitor, attenuate contact pathway or complement activation, or reduce bradykinin production, this may at first appear surprising.
Neg (not) Negative_regulation (reduce) of Gene_expression (production) of bradykinin associated with bradykinin
4) Confidence 0.25 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941790 Disease Relevance 0.49 Pain Relevance 0.23
It is used to inhibit the formation of plasmin and fragments of the Hageman factor, leading to the inhibition of kallikrein and bradykinin production [10].
Negative_regulation (inhibition) of Gene_expression (production) of bradykinin associated with bradykinin
5) Confidence 0.20 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2887436 Disease Relevance 1.04 Pain Relevance 0.12
RESULTS: The AMI group showed a significant reduction in F XII activity, F XII activity-to-concentration ratio, and HMWK concentration.
Negative_regulation (reduction) of Gene_expression (concentration) of HMWK
6) Confidence 0.12 Published 1992 Journal Am. J. Med. Section Body Doc Link 1466361 Disease Relevance 0 Pain Relevance 0
Indeed administration of C1INH concentrate has been shown to acutely reduce bradykinin levels in patients experiencing angioedema attacks [53].
Negative_regulation (reduce) of Gene_expression (levels) of bradykinin associated with edema and bradykinin
7) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 1.01 Pain Relevance 0.29
These data suggest that endogenous bradykinin levels may be lower in NTG patients than in normal subjects.
Negative_regulation (lower) of Gene_expression (levels) of bradykinin associated with glaucoma and bradykinin
8) Confidence 0.09 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.82 Pain Relevance 0.42
It has also been reported that a single dose administration of a glucocorticoid reduces tissue levels of bradykinin and suppresses circulating levels of cortisol and beta-endorphin [25].
Negative_regulation (reduces) of Gene_expression (levels) of bradykinin associated with bradykinin
9) Confidence 0.07 Published 2005 Journal Head Face Med Section Body Doc Link PMC1291385 Disease Relevance 1.03 Pain Relevance 1.22
This seems to be mediated both directly through inhibition of nociceptors and indirectly via decreasing the synthesis of or binding to bradykinin, substance P, and other hyperalgesic compounds.25–28
Negative_regulation (decreasing) of Gene_expression (synthesis) of bradykinin in nociceptors associated with hyperalgesia, nociceptor, bradykinin and substance p
10) Confidence 0.07 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004631 Disease Relevance 0.46 Pain Relevance 0.62
1.3.8 increased levels of bradykinin [116]
Negative_regulation (levels) of Gene_expression (levels) of bradykinin associated with bradykinin
11) Confidence 0.03 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1820789 Disease Relevance 0.52 Pain Relevance 0.35
A moderate reduction of caloric intake by 500-1000 kcal/day has been shown to produce clinically significant weight loss over time and is a safe and achievable goal for most people [27].
Negative_regulation (reduction) of Gene_expression (produce) of weight associated with weight loss
12) Confidence 0.02 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2860346 Disease Relevance 0.16 Pain Relevance 0
However, inhibition of PG biosynthesis is known to indirectly inhibit bradykinin generation.
Negative_regulation (inhibit) of Gene_expression (generation) of bradykinin associated with bradykinin
13) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2276498 Disease Relevance 0.83 Pain Relevance 1.36

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