INT10139

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Context Info
Confidence 0.56
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 64
Total Number 65
Disease Relevance 44.75
Pain Relevance 9.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
platelet 10
plasma 7
vertebral artery 1
anterior 1
granulation 1
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 150 99.92 Very High Very High Very High
aspirin 32 99.44 Very High Very High Very High
fibrosis 80 99.36 Very High Very High Very High
abdominal pain 5 99.32 Very High Very High Very High
Restless leg syndrome 60 98.88 Very High Very High Very High
cva 75 98.68 Very High Very High Very High
ischemia 13 98.60 Very High Very High Very High
corticosteroid 7 97.04 Very High Very High Very High
Arthritis 38 96.76 Very High Very High Very High
Angina 41 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coagulation Disorder 80 100.00 Very High Very High Very High
Necrosis 32 100.00 Very High Very High Very High
INFLAMMATION 180 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 111 99.90 Very High Very High Very High
Hypocalcemia 8 99.84 Very High Very High Very High
Cancer 52 99.78 Very High Very High Very High
Aneurism 2 99.78 Very High Very High Very High
Injury 324 99.74 Very High Very High Very High
Coronary Artery Disease 37 99.68 Very High Very High Very High
Dermatofibroma 10 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelets may adhere to the exposed arterial wall endothelium, stimulating further platelet aggregation and accumulation of leukocytes and fibrin.
Positive_regulation (accumulation) of fibrin in platelet
1) Confidence 0.56 Published 1987 Journal Clin Pharm Section Abstract Doc Link 3311577 Disease Relevance 1.54 Pain Relevance 0.09
The patient developed symptoms after treatment for a ruptured vertebral artery aneurysm, in which fibrin glue was used for reconstruction of the suboccipital bone defect.
Positive_regulation (used) of fibrin in vertebral artery associated with aneurism
2) Confidence 0.50 Published 1996 Journal J. Neurosurg. Section Abstract Doc Link 8609570 Disease Relevance 0.53 Pain Relevance 0.22
0.003) located in an intron of the 177 kb gene encoding the A1 subunit of the coagulation factor XIII (F13A1), a gene previously associated with the risk of venous thromboembolism [13].
Positive_regulation (coagulation) of F13A1 associated with cva and deep vein thrombosis
3) Confidence 0.49 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2880558 Disease Relevance 0.54 Pain Relevance 0.05
This study showed that human fibrin glue is effective in preventing local hemorrhagic complications after inguinal hernia repair in patients with concurrent coagulation disorders.
Positive_regulation (effective) of fibrin glue associated with inguinal hernia
4) Confidence 0.46 Published 2003 Journal Acta bio-medica : Atenei Parmensis Section Abstract Doc Link 15055028 Disease Relevance 0.47 Pain Relevance 0.08
0.003) located in an intron of the 177 kb gene encoding the A1 subunit of the coagulation factor XIII (F13A1), a gene previously associated with the risk of venous thromboembolism [13].
Positive_regulation (coagulation) of factor XIII associated with cva and deep vein thrombosis
5) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2880558 Disease Relevance 0.53 Pain Relevance 0.05
At 2 hours of ischemia, there was edema of the submucosa and lamina propria attributable to accumulation of platelets, fibrin, and neutrophils in capillaries of the lamina propria.
Positive_regulation (accumulation) of fibrin in lamina associated with pressure and volume under development and ischemia
6) Confidence 0.41 Published 1995 Journal Vet. Pathol. Section Abstract Doc Link 7604495 Disease Relevance 0.76 Pain Relevance 0.42
One patient whose heparin lock was not changed for 23 days (for reasons unrelated to the device) required fibrin sheath stripping of his catheters.
Positive_regulation (required) of fibrin
7) Confidence 0.40 Published 1998 Journal ASAIO J. Section Abstract Doc Link 9804487 Disease Relevance 0.19 Pain Relevance 0.07
The surgical approach included complete transection of the palmar/plantar annular ligament of the fetlock and proximal digital annular ligament, which facilitated the removal of fibrin, selective debridement and synovectomy, followed by lavage of the digital sheath.
Positive_regulation (facilitated) of fibrin in annular ligament
8) Confidence 0.40 Published 2000 Journal Vet. Rec. Section Abstract Doc Link 11073001 Disease Relevance 0.56 Pain Relevance 0.08
In 30 patients, a fibrin sealant was placed in the alveolus on one side immediately following the operation, while the other side functioned as control.
Positive_regulation (placed) of fibrin in alveolus
9) Confidence 0.40 Published 1988 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 2455005 Disease Relevance 0.37 Pain Relevance 0.08
Factor XIII concentrate may be useful for alleviating abdominal pain in Henoch-Schönlein purpura patients when corticosteroids are contraindicated
Spec (may) Positive_regulation (useful) of Factor XIII associated with purpura, corticosteroid and abdominal pain
10) Confidence 0.39 Published 2005 Journal J. Dermatol. Section Abstract Doc Link 15906543 Disease Relevance 1.07 Pain Relevance 0.54
Eosinophilia, monocytosis, mild hypocalcemia and an increase in fibrin degradation products were seen in a few patients.
Positive_regulation (increase) of fibrin associated with hypocalcemia and eosinophilia
11) Confidence 0.38 Published 1987 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 3664933 Disease Relevance 1.75 Pain Relevance 0.18
The sealant resulted in an excess of fibrin, which induced fibrosis, securing the urethrovesical junction in an elevated position to the retropubic periosteum.
Positive_regulation (excess) of fibrin in periosteum associated with fibrosis
12) Confidence 0.38 Published 1995 Journal Neurourol. Urodyn. Section Abstract Doc Link 7581473 Disease Relevance 0.26 Pain Relevance 0.13
Our investigation focused on the control of the parameter changes important for ulcer healing: wound surface area, wound appearance (fibrin accumulations, exudation, granulation, and epithelization), ulcer surroundings and associated symptoms.
Positive_regulation (accumulations) of fibrin in granulation associated with injury and ulcers
13) Confidence 0.38 Published 2008 Journal Arch. Dermatol. Res. Section Abstract Doc Link 18629524 Disease Relevance 1.29 Pain Relevance 0.39
[Chemical pleurodesis induced with fibrin glue in the treatment of inoperable spontaneous pneumothorax].
Positive_regulation (induced) of fibrin associated with pneumothorax
14) Confidence 0.20 Published 1989 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Title Doc Link 2615097 Disease Relevance 0.74 Pain Relevance 0.08
Acetylsalicylic acid may protect the patient by increasing fibrin gel porosity.
Positive_regulation (increasing) of fibrin associated with aspirin
15) Confidence 0.18 Published 1996 Journal Eur. Heart J. Section Title Doc Link 8880021 Disease Relevance 0.16 Pain Relevance 0.51
In the nine patients with increased maximal levels of serum troponin T, maximal concentrations of fibrin monomers during the first 48 hours were higher than those in patients with persistently normal troponin T concentrations (6.3+/-4.8 vs. 2.9+/-2.3 mg/L; p = 0.04).
Positive_regulation (concentrations) of fibrin
16) Confidence 0.18 Published 1998 Journal Am. Heart J. Section Abstract Doc Link 9489977 Disease Relevance 1.01 Pain Relevance 0.64
Increases in plasma concentrations of cross-linked fibrin degradation products (XL-FDPs), which reflect increased fibrin turn-over, are a marker of risk for complications of myocardial infarction.
Positive_regulation (increased) of fibrin in plasma associated with myocardial infarction
17) Confidence 0.16 Published 1999 Journal Int. J. Cardiol. Section Abstract Doc Link 10328612 Disease Relevance 0.78 Pain Relevance 0.07
By preventing excess fibrin accumulation in inflamed tissues, the plasminogen activation system also governs the proper evolution of the inflammatory exudates and prevents the possibility of a shift from acute to chronic inflammation.
Positive_regulation (accumulation) of fibrin associated with inflammation
18) Confidence 0.15 Published 2008 Journal Front. Biosci. Section Abstract Doc Link 18508538 Disease Relevance 0.71 Pain Relevance 0.36
The beneficial effects of a moist versus a dry wound environment include: prevention of tissue dehydration and cell death, accelerated angiogenesis, increased breakdown of dead tissue and fibrin, i.e., pericapillary fibrin cuffs, and potentiating the interaction of growth factors with their target cells.
Positive_regulation (increased) of fibrin associated with volume depletion and dehydration, injury and death
19) Confidence 0.12 Published 1994 Journal Am. J. Surg. Section Abstract Doc Link 8109679 Disease Relevance 0.96 Pain Relevance 0.09
Increases in plasma concentrations of cross-linked fibrin degradation products (XL-FDPs), which reflect increased fibrin turn-over, are a marker of risk for complications of myocardial infarction.
Positive_regulation (Increases) of fibrin in plasma associated with myocardial infarction
20) Confidence 0.12 Published 1999 Journal Int. J. Cardiol. Section Abstract Doc Link 10328612 Disease Relevance 0.79 Pain Relevance 0.07

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