INT10140

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Context Info
Confidence 0.07
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 6.07
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ANXA3) cytoplasm (ANXA3)
Anatomy Link Frequency
liver 1
ANXA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 16 97.52 Very High Very High Very High
Pain 5 88.08 High High
alcohol 4 81.44 Quite High
cva 8 79.32 Quite High
anesthesia 2 72.80 Quite High
Angina 5 50.00 Quite Low
depression 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
tricyclic antidepressant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infarction 32 98.38 Very High Very High Very High
Thrombophilia 24 98.26 Very High Very High Very High
Thrombosis 90 97.96 Very High Very High Very High
Abdominal Pain 16 97.52 Very High Very High Very High
Cv General 4 Under Development 12 95.80 Very High Very High Very High
Varicose Veins 8 95.80 Very High Very High Very High
Pressure And Volume Under Development 36 95.12 Very High Very High Very High
Disease 27 94.68 High High
Budd-chiari Syndrome 8 93.92 High High
Mental Disorders 4 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But here in Part IV, Jaspers provides a classification scheme, heavily influenced by Kraepelin, remarkably similar to the nosology DSM-III and ICD-9:

'We have detailed knowledge of particular phenomena, of causal connections and meaningful connections, etc., but complex disease entities remain an endless, inextricable web.

Negative_regulation (nosology) of DSM-III associated with disease
1) Confidence 0.07 Published 2009 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2724409 Disease Relevance 0.58 Pain Relevance 0
We describe the case of a 42-year-old man who presented with abdominal pain attributed to multiple hepatic infarctions who had a combination of homozygosity for the prothrombin gene variant and mild deficiency of antithrombin III (AT III).


Negative_regulation (deficiency) of AT III associated with abdominal pain and infarction
2) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868876 Disease Relevance 1.04 Pain Relevance 0.35
But this is the first report of G20210A homozygosity for the prothrombin gene variant and mild deficiency of AT III affecting the liver.
Negative_regulation (deficiency) of AT III in liver
3) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868876 Disease Relevance 1.52 Pain Relevance 0.04
A thrombophilia screen confirmed a homozygous mutation for the prothrombin gene mutation, with mildly reduced levels of anti-thrombin III (AT III).
Negative_regulation (reduced) of AT III associated with thrombophilia
4) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Abstract Doc Link PMC2868876 Disease Relevance 1.36 Pain Relevance 0.09
However, combinations of factor V Leiden and protein C deficiency, protein S deficiency or AT III deficiency greatly increase the risk of severe and recurrent thrombosis [14].
Negative_regulation (deficiency) of AT III associated with thrombosis
5) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868876 Disease Relevance 1.57 Pain Relevance 0
In both groups, an important formation of TATc was observed early, together with a decrease in PKK levels and consumption of both AT-III and PC, which reached their lowest levels at 24 hours.
Negative_regulation (decrease) of AT-III
6) Confidence 0.01 Published 1998 Journal Am. J. Kidney Dis. Section Abstract Doc Link 9774117 Disease Relevance 0 Pain Relevance 0.14
This was associated with significant reductions in F V, F II, and AT-III activity-to-concentration ratio.
Negative_regulation (reductions) of AT-III
7) Confidence 0.00 Published 1992 Journal Am. J. Med. Section Body Doc Link 1466361 Disease Relevance 0 Pain Relevance 0

General Comments

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