INT101401

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.45
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
cingulate cortex 4
PSNs 2
striatum 2
forebrain 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 15 100.00 Very High Very High Very High
nud 2 98.48 Very High Very High Very High
Dorsal horn neuron 4 96.12 Very High Very High Very High
Inflammation 5 90.32 High High
nMDA receptor antagonist 1 90.24 High High
Hyperalgesia 3 89.36 High High
5HT 4 85.60 High High
Pain 6 82.64 Quite High
alcohol 9 82.16 Quite High
Glutamate 34 76.88 Quite High
Disease Link Frequency Relevance Heat
Dyspepsia 2 98.48 Very High Very High Very High
Anxiety Disorder 6 95.36 Very High Very High Very High
Colitis 3 94.64 High High
Depression 5 92.04 High High
INFLAMMATION 4 90.32 High High
Hyperalgesia 3 89.36 High High
Pressure And Volume Under Development 1 88.68 High High
Nociception 1 85.08 High High
Sleep Disorders 2 80.36 Quite High
Pain 4 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The main results are the postpubertal onset of increased NR1 mRNA expression in all cortical regions and decreased dopamine D2 receptor, substance P and enkephalin mRNA expression in the striatum only in rats lesioned as neonates.
Positive_regulation (increased) of Transcription (expression) of NR1 in striatum
1) Confidence 0.67 Published 2009 Journal Schizophr. Res. Section Body Doc Link 19500946 Disease Relevance 0 Pain Relevance 0
Finally, repeated dosing with MTEP (2 mg/kg i.p.) caused significant reductions in expression of the mRNA encoding the NR1 subunit of the N-methyl-D-aspartate receptor and the GluR2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor in the cingulate cortex.
Positive_regulation (encoding) of Transcription (expression) of N-methyl-D-aspartate receptor in cingulate cortex associated with nmda receptor
2) Confidence 0.49 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014750 Disease Relevance 0.76 Pain Relevance 0.53
We have previously, demonstrated an increase in the C1 cassette of NR1 mRNA expression at 14, 21, and 28 days following TNBS administration.
Positive_regulation (increase) of Transcription (expression) of NR1
3) Confidence 0.45 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16942839 Disease Relevance 0.66 Pain Relevance 0.38
Finally, repeated dosing with MTEP (2 mg/kg i.p.) caused significant reductions in expression of the mRNA encoding the NR1 subunit of the N-methyl-D-aspartate receptor and the GluR2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor in the cingulate cortex.
Positive_regulation (encoding) of Transcription (expression) of NR1 in cingulate cortex associated with nmda receptor
4) Confidence 0.42 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014750 Disease Relevance 0.76 Pain Relevance 0.52
MDMA increased mRNA expression levels of glutamatergic NMDA receptor subunits NR1, NR2A and NR2B in the forebrain cortex, NR2A and 2B in the CPU, and NR1 and NR2A (lower dose) in the hypothalamus.
Positive_regulation (increased) of Transcription (expression) of NR1 in forebrain associated with nmda receptor
5) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.28
CFA injection increased SPR mRNA expression in PSNs at days 1 and 4, and NMDAR mRNA expression at days 1, 4 and 7.
Positive_regulation (increased) of Transcription (expression) of NMDAR in PSNs
6) Confidence 0.29 Published 2002 Journal Ann. Anat. Section Abstract Doc Link 11876485 Disease Relevance 0.26 Pain Relevance 0.89

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