INT10141

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Context Info
Confidence 0.35
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 9.37
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (A2M) extracellular space (A2M) extracellular region (A2M)
enzyme binding (A2M)
Anatomy Link Frequency
plasma 2
glial cells 2
feces 1
lymphocytes 1
saliva 1
A2M (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 9 99.48 Very High Very High Very High
Chronic pancreatitis 5 99.08 Very High Very High Very High
Angina 12 98.96 Very High Very High Very High
Inflammation 36 97.48 Very High Very High Very High
Abeta 4 93.76 High High
cytokine 14 92.80 High High
aspirin 2 92.44 High High
cINOD 4 91.72 High High
Pain 8 70.36 Quite High
spastic colon 25 69.92 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 4 99.84 Very High Very High Very High
Fever 9 99.78 Very High Very High Very High
Pancreatitis 15 99.52 Very High Very High Very High
Inflammatory Bowel Disease 118 99.40 Very High Very High Very High
INFLAMMATION 41 99.30 Very High Very High Very High
Cv General 3 Under Development 12 98.96 Very High Very High Very High
Coronary Artery Disease 5 98.60 Very High Very High Very High
Disease 137 97.20 Very High Very High Very High
Disease Progression 3 96.72 Very High Very High Very High
Mouth Disease 2 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of glial cells and the subsequent expression of a number of proteins including alpha(2)-macroglobulin (alpha(2)M) are associated with the induction of brain tissue inflammation.
Gene_expression (expression) of macroglobulin in glial cells associated with inflammation
1) Confidence 0.35 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399113 Disease Relevance 0.79 Pain Relevance 0.53
NF-kappaB mediates IL-1beta-induced synthesis/release of alpha2-macroglobulin in a human glial cell line.
Gene_expression (synthesis/release) of macroglobulin in glial cell
2) Confidence 0.31 Published 2002 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 12399113 Disease Relevance 0.75 Pain Relevance 0.49
However, human lymphocytes blastogenesis was enhanced after in vitro heating at 39 degrees C. 3) E-rosetting capability and PHA-induced blastogenesis of lymphocytes were depressed just immediately after the treatment in patients treated with TBHT, which returned to pretreatment levels within a week. 4) Decreased PHA and PPD skin reactions remained up to 3 weeks after the last TBHT. 5) Serum levels of immunoglobulin, complement and alpha 2-macroglobulin were slightly affected by TBHT, and serum haptoglobin showed a tendency to decrease.
Gene_expression (levels) of 2-macroglobulin in lymphocytes associated with fever
3) Confidence 0.16 Published 1983 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 6870291 Disease Relevance 0.92 Pain Relevance 0.14
Levels of antithrombin III, alpha 2-macroglobulin, and alpha 1-antitrypsin in acute ischemic heart disease.
Gene_expression (Levels) of alpha 2-macroglobulin in heart associated with coronary artery disease
4) Confidence 0.09 Published 1981 Journal J. Lab. Clin. Med. Section Title Doc Link 6161197 Disease Relevance 0.52 Pain Relevance 0.08
It is known for example that the level of alpha-2-macroglobulin, alpha-1-antitripsin, elastase and also albumin in saliva may be good indicators of gingivitis and/or periodontitis.
Gene_expression (level) of alpha-2-macroglobulin in saliva associated with periodontitis and mouth disease
5) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674305 Disease Relevance 0.77 Pain Relevance 0.07
Alpha I antitrypsin and alpha 2 macroglobulin levels in these cases showed no significant difference compared to normals.
Gene_expression (levels) of alpha 2 macroglobulin
6) Confidence 0.07 Published 1990 Journal Indian Heart J Section Abstract Doc Link 1711506 Disease Relevance 0.93 Pain Relevance 0.35
In contrast, the plasma levels of alpha 2-macroglobulin were drastically lowered.
Gene_expression (levels) of alpha 2-macroglobulin in plasma
7) Confidence 0.03 Published 1981 Journal Klin. Wochenschr. Section Abstract Doc Link 7019564 Disease Relevance 0.53 Pain Relevance 0.07
In 2004, Bachman et al. [2] demonstrated that CO2 insufflation reduces the inflammatory response in rats based on reduced levels of alpha-2 macroglobulin mRNA and beta fibrinogen.
Gene_expression (levels) of alpha-2 macroglobulin mRNA associated with inflammatory response
8) Confidence 0.03 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.91 Pain Relevance 0.16
An increase of elastase 1, alpha 1-antitrypsin and alpha 2-macroglobulin was detected in pancreatic cancer, chronic pancreatitis and extra-pancreatic diseases; no changes were found for serum immunoreactive trypsin.
Gene_expression (detected) of alpha 2-macroglobulin associated with pancreatitis, pancreatic cancer and chronic pancreatitis
9) Confidence 0.02 Published 1986 Journal Enzyme Section Abstract Doc Link 2427333 Disease Relevance 0.75 Pain Relevance 0.20
The levels of alpha2-macroglobulin in the feces have a positive relationship with the activity index in CD but not in subjects with UC.32
Gene_expression (levels) of alpha2-macroglobulin in feces associated with inflammatory bowel disease and disease
10) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.00 Pain Relevance 0.16
Plasma antigen concentrations and/or activities of high-molecular-weight kininogen (HMWK), fibrinogen, fibronectin, plasminogen, D-dimer, tissue plasminogen activator (t-PA), alpha 2-antiplasmin, alpha 2-macroglobulin, alpha 1-antitrypsin, protein C, total and free protein S, antithrombin III (AT-III), von Willebrand factor (vWF), factors (F) XII, XI, IX, VIII, VII, X, V, II, and XIII, and plasma antiplasmin activity were measured using appropriate functional or immunologic assays.
Gene_expression (concentrations) of 2-macroglobulin in plasma
11) Confidence 0.01 Published 1992 Journal Am. J. Med. Section Abstract Doc Link 1466361 Disease Relevance 0.77 Pain Relevance 0.35
In order to investigate modifications of serum levels of elastase 1, immunoreactive trypsin, alpha 1-antitrypsin and alpha 2-macroglobulin in chronic pancreatic disease, and to speculate on the possible relationships among these parameters, the enzymes and inhibitors were assayed in the sera of 33 control subjects, 34 pancreatic cancer, 28 chronic pancreatitis and 36 extra-pancreatic diseases.
Spec (investigate) Gene_expression (levels) of alpha 2-macroglobulin associated with pancreatic cancer, pancreatitis and chronic pancreatitis
12) Confidence 0.01 Published 1986 Journal Enzyme Section Abstract Doc Link 2427333 Disease Relevance 0.66 Pain Relevance 0.16

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