INT101433

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Context Info
Confidence 0.10
First Reported 2002
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 5.77
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 4
CD86 2
Atp9a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 218 93.56 High High
cytokine 62 92.48 High High
metalloproteinase 2 89.00 High High
chemokine 14 86.44 High High
addiction 4 77.76 Quite High
Multiple sclerosis 2 71.84 Quite High
tolerance 5 48.24 Quite Low
palliative 2 40.96 Quite Low
Potency 10 36.88 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Candida Infection 137 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 10 99.64 Very High Very High Very High
Sprains And Strains 35 99.50 Very High Very High Very High
Keloid Scars 10 96.24 Very High Very High Very High
Death 9 95.44 Very High Very High Very High
Apoptosis 6 94.08 High High
Cancer 72 93.76 High High
INFLAMMATION 208 93.56 High High
Infection 1 92.48 High High
Targeted Disruption 44 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to its control over expression of various genes including MHC class II, CIITA has also been postulated to participate in CD4+ Th cell differentiation.
Regulation (control) of Gene_expression (expression) of class II
1) Confidence 0.10 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.14 Pain Relevance 0.09
Besides its function as a key regulator for the expression of MHC class II molecule (1, 2), CIITA has been known to play additional roles in Th differentiation and activation-induced cell death (8, 9, 12, 14, 18).
Regulation (regulator) of Gene_expression (expression) of class II associated with death
2) Confidence 0.10 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.60 Pain Relevance 0.16
Effects of in vivo exposure to CSBG on the expression of MHC class II with or without costimulatory molecules and APC-related markers in lung cells in the presence or absence of OVA
Regulation (Effects) of Gene_expression (expression) of class II in lung associated with candida infection
3) Confidence 0.04 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.29 Pain Relevance 0
Here, we investigate the effect of Curosurf on the pulmonary synthesis of sPLA(2)-IIA in this ALI model.
Spec (investigate) Regulation (effect) of Gene_expression (synthesis) of IIA associated with adult respiratory distress syndrome
4) Confidence 0.04 Published 2002 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 11880300 Disease Relevance 0.42 Pain Relevance 0.03
Again a great difference was observed among the LAB strains in their capacity to up-regulate the expression of MHC class II and co-stimulatory molecules (CD86, CD40) (Fig. 3).
Regulation (regulate) of Gene_expression (expression) of class II in CD86 associated with sprains and strains
5) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.30 Pain Relevance 0.42
Again, there was no correlation between Top IIa expression and DTC-BM.
Neg (no) Regulation (correlation) of Gene_expression (expression) of IIa
6) Confidence 0.03 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410751 Disease Relevance 0.18 Pain Relevance 0.04
MSCs are immuno-modulatory and express no MHC class II, making hMSCs a viable therapeutic across tissue typing [5,6]. hMSCs produce large quantities of bioactive factors which provide molecular signatures for the pathway and activity status of the responding cells [7,8].
Regulation (provide) of Neg (no) Gene_expression (express) of class II
7) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2987779 Disease Relevance 0.65 Pain Relevance 0.18
MSCs are immuno-modulatory and express no MHC class II, making hMSCs a viable therapeutic across tissue typing [5,6]. hMSCs produce large quantities of bioactive factors which provide molecular signatures for the pathway and activity status of the responding cells [7,8].
Regulation (responding) of Neg (no) Gene_expression (express) of class II
8) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2987779 Disease Relevance 0.67 Pain Relevance 0.19
Effect of surfactant on pulmonary expression of type IIA PLA(2) in an animal model of acute lung injury.
Regulation (Effect) of Gene_expression (expression) of IIA in lung associated with adult respiratory distress syndrome
9) Confidence 0.02 Published 2002 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Title Doc Link 11880300 Disease Relevance 0.52 Pain Relevance 0.03

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