INT101439

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Context Info
Confidence 0.24
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2) extracellular space (Cck) extracellular region (Cck)
plasma membrane (Agtr2) DNA binding (Cck) transcription factor binding (Agtr2)
Anatomy Link Frequency
brain 1
Cck (Mus musculus)
Agtr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 3 99.84 Very High Very High Very High
Opioid 6 98.12 Very High Very High Very High
Pain 1 81.12 Quite High
addiction 1 80.08 Quite High
Endogenous opioid 1 75.00 Quite High
Eae 1 63.12 Quite High
Enkephalin 1 59.60 Quite High
Morphine 2 57.36 Quite High
Hyperalgesia 1 55.12 Quite High
antagonist 1 46.80 Quite Low
Disease Link Frequency Relevance Heat
Pain 1 81.12 Quite High
Drug Dependence 1 80.48 Quite High
Hypersensitivity 1 65.04 Quite High
Hyperalgesia 1 55.12 Quite High
Nociception 1 53.20 Quite High
Opiate Addiction 1 31.04 Quite Low
Targeted Disruption 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of the brain CCK2 receptor by the C-terminal octapeptide CCK8 of cholecystokinin (CCK) negatively modulates opioid responses.
CCK8 Positive_regulation (Stimulation) of CCK2 receptor in brain associated with opioid and cholecystokinin
1) Confidence 0.24 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11880531 Disease Relevance 0.33 Pain Relevance 0.80

General Comments

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