INT101443

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2001
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.21
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Gcg) extracellular space (Gcg) cytoplasm (Gcg)
Anatomy Link Frequency
pancreas 8
Penk (Rattus norvegicus)
Gcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 16 98.00 Very High Very High Very High
opioid receptor 4 96.76 Very High Very High Very High
Enkephalin 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 16 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, Leu-Enk failed to significantly stimulate insulin and glucagon secretion from the pancreas of diabetic rats.
Leu-Enk Neg (failed) Positive_regulation (stimulate) of Localization (secretion) of glucagon in pancreas associated with diabetes mellitus
1) Confidence 0.50 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11880925 Disease Relevance 0.30 Pain Relevance 0.25
In conclusion, Leu-Enk stimulates insulin and glucagon secretion from the pancreas of normal rat through the cholinergic, alpha-2 adrenergic and opioid receptor pathways.
Leu-Enk Positive_regulation (stimulates) of Localization (secretion) of glucagon in pancreas associated with opioid receptor
2) Confidence 0.36 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11880925 Disease Relevance 0.29 Pain Relevance 0.24
In contrast, Leu-Enk failed to significantly stimulate insulin and glucagon secretion from the pancreas of diabetic rats.
Leu-Enk Neg (failed) Positive_regulation (stimulate) of Localization (secretion) of glucagon in pancreas associated with diabetes mellitus
3) Confidence 0.36 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11880925 Disease Relevance 0.30 Pain Relevance 0.25
In the same way, Leu-Enk at concentrations of 10(-12)M and 10(-9)M induced significant (p < 0.05) increases in glucagon release from the pancreas of normal rats.
Leu-Enk Positive_regulation (increases) of Localization (release) of glucagon in pancreas
4) Confidence 0.34 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11880925 Disease Relevance 0.31 Pain Relevance 0.31

General Comments

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