INT10145

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 28
Total Number 30
Disease Relevance 12.68
Pain Relevance 7.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
plasma 6
liver 4
blood 2
nucleus accumbens 2
vein 2
Plg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
Nucleus accumbens 4 99.24 Very High Very High Very High
Chronic pancreatitis 11 98.76 Very High Very High Very High
cocaine 32 98.72 Very High Very High Very High
Angina 26 98.48 Very High Very High Very High
long-term potentiation 1 97.72 Very High Very High Very High
headache 3 97.36 Very High Very High Very High
Peripheral nerve injury 3 96.96 Very High Very High Very High
Ventral tegmentum 2 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 21 99.76 Very High Very High Very High
Pancreatic Cancer 9 99.64 Very High Very High Very High
Reprotox - General 1 11 99.08 Very High Very High Very High
Thrombosis Related Under Development 1 98.82 Very High Very High Very High
Pancreatitis 11 98.76 Very High Very High Very High
Thrombophilia 2 98.60 Very High Very High Very High
Cv General 3 Under Development 27 98.48 Very High Very High Very High
Hypoxia 10 98.16 Very High Very High Very High
Anaemia 1 98.16 Very High Very High Very High
Nociception 1 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brattleboro rats placed in metabolism cages were injected with morphine (Mor), naloxone (Nal), D- and L-aspartic acid (D- and L-Asp), D-phenylalanine (D-Phe), D-leucine (D-Leu) and prolyl-leucyl-glycinamide (PLG), alone and in suitable combinations.
Gene_expression (injected) of PLG associated with narcan and morphine
1) Confidence 0.62 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6694997 Disease Relevance 0 Pain Relevance 0.81
The purpose of this study is to examine the expression of plasminogen activators in primary afferents and its role in nociceptive pathways after peripheral nerve injury.
Spec (examine) Gene_expression (expression) of plasminogen in peripheral nerve associated with nociception, nervous system injury and peripheral nerve injury
2) Confidence 0.45 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.40 Pain Relevance 0.40
The combined effects of orchiectomy and estrogen administration on synthesis of selected hepatic secretory proteins--antithrombin (AT) III, plasminogen, fibrinogen, factor II (prothrombin), factor VII, fibronectin, and albumin--were studied using the isolated rat liver perfused in vitro for ten hours.
Gene_expression (synthesis) of plasminogen in liver
3) Confidence 0.45 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.08
It is considered that venous thrombosis may be a result of low concentrations of the activator of plasminogen levels in the vein wall, which produces a mediocre fibrinolytic response.
Gene_expression (levels) of plasminogen in vein associated with thrombosis related under development
4) Confidence 0.37 Published 1987 Journal Phlebologie Section Abstract Doc Link 3128802 Disease Relevance 0.48 Pain Relevance 0.09
Synthesis of plasminogen in this group of perfusions was progressively decreased as the concentration of DES administered to the rat liver donor increased.
Gene_expression (Synthesis) of plasminogen in liver
5) Confidence 0.35 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.06
Overexpression of plasminogen activators in the nucleus accumbens enhances cocaine-, amphetamine- and morphine-induced reward and behavioral sensitization.
Gene_expression (Overexpression) of plasminogen in nucleus accumbens associated with nucleus accumbens, morphine and cocaine
6) Confidence 0.28 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.55
Cocaine and many other psychostimulants strongly induce urokinase-type plasminogen activator (uPA) expression in the mesolimbic dopaminergic pathway, which plays a major role in drug-mediated behavioral plasticity [Bahi A, Boyer F, Gumy C, Kafri T, Dreyer JL.
Gene_expression (expression) of plasminogen associated with cocaine
7) Confidence 0.19 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.24
The level of plasma basic plasminogen activator activity, plasminogen, fibrinogen and serum fibrin degradation products (FDP) were determined also.
Gene_expression (products) of plasminogen in plasma
8) Confidence 0.15 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517077 Disease Relevance 0.77 Pain Relevance 0.17
The levels of plasma plasminogen, fibrinogen and FDP were also significantly changed in these patients.
Gene_expression (levels) of plasminogen in plasma
9) Confidence 0.13 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517077 Disease Relevance 0.81 Pain Relevance 0.20
Concentrations of plasminogen, fibrinogen and fibrin degradation products were also determined.
Gene_expression (products) of plasminogen
10) Confidence 0.10 Published 1982 Journal Anaesthesia Section Abstract Doc Link 7081646 Disease Relevance 0 Pain Relevance 0.04
The authors examined the activities of plasminogen activator, its inhibitor, the levels of C protein, antithrombin III, alpha 2-antiplasmin, plasminogen, fibrinogen, fibrinogen/fibrin degradation products in 22 patients with unstable angina by using the vein occlusive test.
Gene_expression (levels) of plasminogen in vein associated with angina
11) Confidence 0.10 Published 1991 Journal Kardiologiia Section Abstract Doc Link 1676768 Disease Relevance 0.25 Pain Relevance 0.39
The mean activity values of the tissue activator inhibitor plasminogen and C-protein, the levels of plasminogen, antithrombin III, and fibrinogen remained unchanged.
Gene_expression (levels) of plasminogen
12) Confidence 0.07 Published 1993 Journal Kardiologiia Section Abstract Doc Link 8377358 Disease Relevance 0.22 Pain Relevance 0.07
The following were studied in both groups: (1) markers of coagulation activity (prekallikrein [PKK] levels and formation of thrombin-antithrombin complexes [TATc]), (2) inhibitors and suppressors of hemostasis (antithrombin III [AT-III] and protein C [PC] activity), (3) markers of fibrinolysis activation (levels of plasminogen [PLG] and of alpha2-antiplasmin [alpha2-APL]), and (4) markers of endothelial damage (tissue plasminogen activator [TPA] and thrombomodulin [TMD]).
Gene_expression (levels) of plasminogen
13) Confidence 0.05 Published 1998 Journal Am. J. Kidney Dis. Section Abstract Doc Link 9774117 Disease Relevance 0.06 Pain Relevance 0.16
In addition to cardiological and angiological examinations, the lipid status and levels of fibrinogen, plasma viscosity, F 1+2, plasminogen, plasminogen activator inhibitor-1, D-dimer, and C-reactive protein of the participants were determined.
Gene_expression (levels) of plasminogen in plasma
14) Confidence 0.05 Published 1999 Journal Eur. Heart J. Section Body Doc Link 10493848 Disease Relevance 0.08 Pain Relevance 0
In addition to cardiological and angiological examinations, the lipid status and levels of fibrinogen, plasma viscosity, F 1+2, plasminogen, plasminogen activator inhibitor-1, D-dimer, and C-reactive protein of the participants were determined.
Gene_expression (levels) of plasminogen in plasma
15) Confidence 0.05 Published 1999 Journal Eur. Heart J. Section Body Doc Link 10493848 Disease Relevance 0.08 Pain Relevance 0
Anti-angiogenic factors are thrombospondin-1 (a matrix glycoprotein), angiostatin (a cleaved product of plasminogen), endostatin (a cleaved part of collagen XVIII), cleaved PRL and GH fragments, and cleaved perlecan (796).
Gene_expression (product) of plasminogen
16) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.12 Pain Relevance 0.06
When comparing patients in whom coronary artery recanalization occurred vs those in whom the artery remained occluded, those in whom recanalization was achieved had greater alterations in fibrinogen, prothrombin time, activated partial thromboplastin time, fibrin/fibrinogen degradation products and plasminogen by thrombolytic therapy than did those in whom recanalization was not achieved (p less than 0.05 for all variables).
Gene_expression (products) of plasminogen in artery
17) Confidence 0.04 Published 1985 Journal Am. J. Cardiol. Section Abstract Doc Link 4036824 Disease Relevance 0.29 Pain Relevance 0.08
Hematological tests show: mild anemia with leucocytosis; prolonged PT, PTT and ThT; decreased fibrinogen, factor V, factor XIII, plasminogen and alpha2-antiplasmin levels; increased factor VIII:c, von Willebrand factor, and FDPs/D-dimers levels with normal ATIII and platelets.
Gene_expression (levels) of plasminogen in platelets associated with anaemia
18) Confidence 0.04 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.71 Pain Relevance 0.13
A complete coagulation profile, including thrombin time, platelet count, protein C, protein S, antithrombin III, homocysteine level, factor V Leiden mutation, plasminogen, and prothrombin G20210A mutation, was obtained in patients diagnosed with superior mesenteric vein thrombosis.
Gene_expression (time) of plasminogen in superior mesenteric vein
19) Confidence 0.03 Published 2003 Journal Dis. Colon Rectum Section Body Doc Link 12792441 Disease Relevance 0.16 Pain Relevance 0
Overexpression of plasminogen activators in the nucleus accumbens enhances cocaine-, amphetamine- and morphine-induced reward and behavioral sensitization.
Gene_expression (Overexpression) of plasminogen in nucleus accumbens associated with nucleus accumbens, morphine and cocaine
20) Confidence 0.03 Published 2008 Journal Genes Brain Behav. Section Title Doc Link 17680802 Disease Relevance 0 Pain Relevance 0.55

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