INT10146

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Context Info
Confidence 0.40
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 17.11
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)
Anatomy Link Frequency
plasma 7
platelet 4
blood 1
pituitary 1
vascular endothelium 1
Vwf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 51 100.00 Very High Very High Very High
ischemia 28 99.08 Very High Very High Very High
cva 43 97.92 Very High Very High Very High
Infliximab 32 97.36 Very High Very High Very High
headache 8 95.92 Very High Very High Very High
antagonist 68 93.88 High High
withdrawal 9 92.76 High High
aspirin 94 88.28 High High
bradykinin 5 83.44 Quite High
Pain 6 78.88 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 53 100.00 Very High Very High Very High
Hypertension 6 99.58 Very High Very High Very High
Disease 83 99.54 Very High Very High Very High
Hemorrhage 136 99.48 Very High Very High Very High
Adhesions 35 99.34 Very High Very High Very High
Myocardial Infarction 41 99.24 Very High Very High Very High
Hemorrhagic Diathesis 2 99.16 Very High Very High Very High
Coronary Artery Disease 23 99.08 Very High Very High Very High
Thrombotic Thrombocytopenic Purpura 5 99.04 Very High Very High Very High
Congenital Anomalies 5 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the 8 AM to noon period, the detected vWf levels decreased significantly in both TMI groups.
Negative_regulation (decreased) of vWf associated with ischemia
1) Confidence 0.40 Published 2003 Journal Angiology Section Abstract Doc Link 12785021 Disease Relevance 2.06 Pain Relevance 1.25
We hypothesized that the concentrations of hs-CRP and vWF are substantially increased in patients with unstable angina pectoris (UAP) and noticeably decreased following coronary stenting along with atorvastatin therapy.
Negative_regulation (decreased) of vWF associated with angina
2) Confidence 0.29 Published 2006 Journal International heart journal Section Abstract Doc Link 16960405 Disease Relevance 0.45 Pain Relevance 0.50
It displays its effect on protecting vascular endothelia and anti-angina pectoris partially by decreasing the plasma levels of ET, vWF, sVCAM-1 and sICAM-1 and elevating the level of NO.


Negative_regulation (decreasing) of vWF in plasma
3) Confidence 0.22 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0 Pain Relevance 0
RESULTS: (1) The clinical symptoms as frequency and persistent time of angina pectoris in the treated group were bettered significantly after treatment and the dosage of nitroglycerin used decreased (all P < 0.01), showing significant difference when compared with those in the control group (P < 0.05). (2) The effective rates on UAP symptoms and ECG in the treated group were 86.7% and 76.7% respectively, which were significantly higher than those in the control group (70.0% and 63.3%, P < 0.05). (3) Laboratory examination showed in the control group, changes only displayed in the decrease of vWF and ET and increase of NO (all P < 0.05), while in the treated group, plasma levels of vWF, ET, sVCAM-1 and sICAM-1 after treatment significantly decreased and were lower than those in the control group (P < 0.01), but NO elevated significantly and was higher than that in the control group (P < 0.01).
Negative_regulation (decrease) of vWF in plasma
4) Confidence 0.22 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0 Pain Relevance 0
In hypertensive patients, doxazosin lowers von Willebrand factor commensurate with blood pressure, but it does not lower high levels of endothelin-1 while atenolol does [19].
Negative_regulation (lowers) of von Willebrand factor in blood associated with hypertension
5) Confidence 0.21 Published 2002 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC134479 Disease Relevance 0.86 Pain Relevance 0.15
In this study eight of nine consecutive patients with bleeding from angioectasias had a loss of the largest multimers of the VWF.
Negative_regulation (loss) of VWF associated with hemorrhage
6) Confidence 0.20 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2955688 Disease Relevance 1.74 Pain Relevance 0
A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding.
Negative_regulation (deficiency) of vWf associated with hemorrhage
7) Confidence 0.16 Published 1999 Journal J. Periodontol. Section Abstract Doc Link 10368060 Disease Relevance 0.53 Pain Relevance 0.12
A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding.
Negative_regulation (deficiency) of von Willebrand factor associated with hemorrhage
8) Confidence 0.16 Published 1999 Journal J. Periodontol. Section Abstract Doc Link 10368060 Disease Relevance 0.53 Pain Relevance 0.12
Their endothelial origin was confirmed by the positive labelling of von Willebrand Factor (vWF), CD31 and electron microscope.
Negative_regulation (labelling) of vWF
9) Confidence 0.15 Published 2005 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 16080813 Disease Relevance 0.26 Pain Relevance 0
Their endothelial origin was confirmed by the positive labelling of von Willebrand Factor (vWF), CD31 and electron microscope.
Negative_regulation (labelling) of von Willebrand Factor
10) Confidence 0.15 Published 2005 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 16080813 Disease Relevance 0.26 Pain Relevance 0
The bleeding occurs in this disorder primarily because of abnormalities in platelet adhesion, due to a primary deficiency or defect in the von Willebrand factor (vWF) often with a concomitant decrease in factor VIII (FVIII) levels.
Negative_regulation (defect) of vWF in platelet associated with congenital anomalies, hemorrhage and adhesions
11) Confidence 0.14 Published 2006 Journal Thromb. Res. Section Abstract Doc Link 16580053 Disease Relevance 0.82 Pain Relevance 0
Recently, we showed reduced activity of a VWF-cleaving protease (ADAMTS13) in AMI patients.
Negative_regulation (reduced) of VWF associated with myocardial infarction
12) Confidence 0.13 Published 2008 Journal Thromb. Res. Section Abstract Doc Link 18295305 Disease Relevance 0.46 Pain Relevance 0.34
MATERIALS AND METHODS: Plasma VWF and ADAMTS13 levels (mU/ml) were measured in 45 patients with UA, 55 with stable exertional angina (SEA) and 47 with chest pain syndrome (CPS) at the time of coronary angiography.
Negative_regulation (measured) of VWF in Plasma
13) Confidence 0.13 Published 2008 Journal Thromb. Res. Section Body Doc Link 18295305 Disease Relevance 0.19 Pain Relevance 0
In a few case reports addressing the related microangiopathy of thrombotic thrombocytopenic purpura (TTP), which is characterised by a significant reduction of the von Willebrand factor (vWF) cleaving serum protease ADAMTS-13, encouraging results have been achieved by an immediate plasma exchange.
Negative_regulation (reduction) of vWF in plasma associated with thrombotic thrombocytopenic purpura
14) Confidence 0.11 Published 2009 Journal Z Gastroenterol Section Abstract Doc Link 19280543 Disease Relevance 0.94 Pain Relevance 0.08
RESULTS: (1) The clinical symptoms as frequency and persistent time of angina pectoris in the treated group were bettered significantly after treatment and the dosage of nitroglycerin used decreased (all P < 0.01), showing significant difference when compared with those in the control group (P < 0.05). (2) The effective rates on UAP symptoms and ECG in the treated group were 86.7% and 76.7% respectively, which were significantly higher than those in the control group (70.0% and 63.3%, P < 0.05). (3) Laboratory examination showed in the control group, changes only displayed in the decrease of vWF and ET and increase of NO (all P < 0.05), while in the treated group, plasma levels of vWF, ET, sVCAM-1 and sICAM-1 after treatment significantly decreased and were lower than those in the control group (P < 0.01), but NO elevated significantly and was higher than that in the control group (P < 0.01).
Negative_regulation (decreased) of vWF in plasma
15) Confidence 0.10 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0 Pain Relevance 0
A consistent decrease in vWF was ascertained for all particulate pollutants for lag 2 and for the 5-day-mean (table 5 and figure 2).
Negative_regulation (decrease) of vWF
16) Confidence 0.08 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2762952 Disease Relevance 0.12 Pain Relevance 0.03
A significant decrease of vWF was also found for lag 1 with EC and OC.
Negative_regulation (decrease) of vWF
17) Confidence 0.08 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2762952 Disease Relevance 0.19 Pain Relevance 0
CONCLUSION: TXL might protect vascular endothelium, improve clinical therapeutic effect by path of decreasing blood levels of ET, vWF and partial cellular adhesive factor, and increasing the level of NO.


Negative_regulation (decreasing) of vWF in vascular endothelium
18) Confidence 0.08 Published 2003 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 14503056 Disease Relevance 0 Pain Relevance 0
Another peculiarity of pituitary vessels is the lack of von Willebrand factor.
Negative_regulation (lack) of von Willebrand factor in pituitary
19) Confidence 0.07 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0
Similarly, vWf was elevated at baseline and significantly reduced after 1 year of treatment with perindopril (p < 0.001).
Negative_regulation (reduced) of vWf
20) Confidence 0.07 Published 2009 Journal Drugs Section Abstract Doc Link 19275271 Disease Relevance 1.31 Pain Relevance 0.17

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