INT10147

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Context Info
Confidence 0.76
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 28
Total Number 28
Disease Relevance 17.73
Pain Relevance 5.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinc1)
Anatomy Link Frequency
plasma 5
liver 3
blood 2
platelet 2
white matter 2
Serpinc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 47 99.92 Very High Very High Very High
alcohol 9 98.88 Very High Very High Very High
Angina 16 98.68 Very High Very High Very High
Migraine 18 98.14 Very High Very High Very High
imagery 19 97.12 Very High Very High Very High
abdominal pain 4 96.28 Very High Very High Very High
epidural 5 92.96 High High
Pain 18 91.44 High High
analgesia 6 87.80 High High
headache 4 87.44 High High
Disease Link Frequency Relevance Heat
Coagulation Disorder 23 100.00 Very High Very High Very High
Cv General 3 Under Development 23 99.92 Very High Very High Very High
Disorders Of Creatine Metabolism 1 99.92 Very High Very High Very High
Disseminated Intravascular Coagulation 4 99.48 Very High Very High Very High
Systemic Lupus Erythematosus 7 99.46 Very High Very High Very High
Retina Disease 15 98.92 Very High Very High Very High
Thrombocytopenia 2 98.86 Very High Very High Very High
Hemorrhage 13 98.72 Very High Very High Very High
Fever 9 98.40 Very High Very High Very High
Headache 22 98.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three cases had abnormal levels of antithrombin III.
Gene_expression (levels) of antithrombin III
1) Confidence 0.76 Published 2004 Journal Acta Med. Okayama Section Abstract Doc Link 15255506 Disease Relevance 1.18 Pain Relevance 0.21
Complete blood examinations, autoantibodies, antiphospholipids antibodies including anticardiolipin and lupus anticoagulant (aCL, LAC), antithrombin III, Protein C and S serum levels were ascertained in the subjects who presented white matter lesions on MRI.
Gene_expression (levels) of antithrombin III in white matter associated with systemic lupus erythematosus and imagery
2) Confidence 0.66 Published 2006 Journal Eur. J. Neurol. Section Abstract Doc Link 17116221 Disease Relevance 0.80 Pain Relevance 0.82
The results of blood coagulation studies, including levels of antiphospholipid antibodies, proteins C and S, and antithrombin III, were normal.
Gene_expression (levels) of antithrombin III in blood
3) Confidence 0.66 Published 2005 Journal Acta Paediatr. Section Abstract Doc Link 15981763 Disease Relevance 0.72 Pain Relevance 0.22
Based on the subsequent normalization of her antithrombin III levels, however, it appears that her acquired deficiency resulted from either accelerated utilization associated with an extensive thrombus or oral contraceptive use or the combination of both.
Gene_expression (levels) of antithrombin III associated with thrombosis
4) Confidence 0.66 Published 1995 Journal J Adolesc Health Section Abstract Doc Link 8519788 Disease Relevance 1.02 Pain Relevance 0.11
Antithrombin III levels in another female sibling, who was free of symptoms, were normal (80% to 120%).
Gene_expression (levels) of Antithrombin III
5) Confidence 0.60 Published 1990 Journal J. Vasc. Surg. Section Abstract Doc Link 2325220 Disease Relevance 0.79 Pain Relevance 0.13
In migraine patients with white matter lesions, antiphospholipid antibodies were not detected and serum levels of antithrombin III, and proteins C and S were normal.
Gene_expression (levels) of antithrombin III in white matter associated with migraine
6) Confidence 0.59 Published 2006 Journal Eur. J. Neurol. Section Abstract Doc Link 17116221 Disease Relevance 0.74 Pain Relevance 0.72
Pretreatment with DES resulted in significant increases in cumulative synthesis of factors II (65%) and VII (76%) and significant reduction in cumulative synthesis of both antithrombin III (20%; P = .03) and plasminogen (27%; P less than .01) compared to control perfusions, but synthesis of fibrinogen, fibronectin, and albumin was not significantly affected by addition of the hormone.
Gene_expression (synthesis) of antithrombin III
7) Confidence 0.51 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.08
The combined effects of orchiectomy and estrogen administration on synthesis of selected hepatic secretory proteins--antithrombin (AT) III, plasminogen, fibrinogen, factor II (prothrombin), factor VII, fibronectin, and albumin--were studied using the isolated rat liver perfused in vitro for ten hours.
Gene_expression (synthesis) of antithrombin in liver
8) Confidence 0.51 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.08
Levels of antithrombin III, protein C, and protein S were all normal.
Gene_expression (Levels) of antithrombin III
9) Confidence 0.46 Published 1997 Journal Am. J. Kidney Dis. Section Abstract Doc Link 9100053 Disease Relevance 1.02 Pain Relevance 0.17
Nevertheless, the use of contraceptives has been implicated in triggering it by diminishing the synthesis of antithrombin III.
Gene_expression (synthesis) of antithrombin III
10) Confidence 0.31 Published 1988 Journal Pol Tyg Lek Section Abstract Doc Link 2457208 Disease Relevance 0.46 Pain Relevance 0.19
Both lasofoxifene and raloxifene reduced levels of fibrinogen and antithrombin III compared with placebo, with the reduction greater with lasofoxifene than with raloxifene.
Gene_expression (levels) of antithrombin III
11) Confidence 0.12 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2773750 Disease Relevance 0.56 Pain Relevance 0.03
Six women without hypertension or proteinuria, admitted for severe upper abdominal pain in the third trimester of pregnancy had elevated serum liver enzymes (SGOT, SGPT), markedly increased serum LDH levels, thrombocytopenia and abnormal blood coagulation tests, in particular low antithrombin III levels, indicating disseminated intravascular coagulation (DIC).
Gene_expression (levels) of antithrombin III in liver associated with abdominal pain, proteinuria, hypertension, disseminated intravascular coagulation and thrombocytopenia
12) Confidence 0.12 Published 1986 Journal Br J Obstet Gynaecol Section Abstract Doc Link 3511956 Disease Relevance 0.95 Pain Relevance 0.10
Postoperative changes in various haemostatic parameters (capillary bleeding time, platelet count, fibrinogen, fibrinmonomers, prothrombin, antithrombin III, factor VIII procoagulant, factor VIII antigen, euglobulin clot lysis time, streptokinase lysis time, fibrinogen related antigens, alpha 1-antitrypsin and alpha 2-macroglobulin) plasma glucose and cortisol were studied in 12 female patients undergoing elective abdominal hysterectomy during either general anaesthesia or epidural analgesia (T4-S5).
Gene_expression (procoagulant) of antithrombin III in plasma associated with epidural, hemorrhage and analgesia
13) Confidence 0.09 Published 1981 Journal Br J Surg Section Abstract Doc Link 7225737 Disease Relevance 0.15 Pain Relevance 0.39
The authors examined the activities of plasminogen activator, its inhibitor, the levels of C protein, antithrombin III, alpha 2-antiplasmin, plasminogen, fibrinogen, fibrinogen/fibrin degradation products in 22 patients with unstable angina by using the vein occlusive test.
Gene_expression (levels) of antithrombin III in vein associated with angina
14) Confidence 0.08 Published 1991 Journal Kardiologiia Section Abstract Doc Link 1676768 Disease Relevance 0.25 Pain Relevance 0.38
In all patients plasma levels of protein C, protein S, antithrombin III (AT III), antiphospholipid antibodies (ApA) and homocysteine were detected.
Gene_expression (detected) of antithrombin III in plasma
15) Confidence 0.08 Published 2004 Journal Neurol. Sci. Section Abstract Doc Link 15624088 Disease Relevance 0.93 Pain Relevance 0.14
Protein C, protein S and antithrombin III levels were normal.
Gene_expression (levels) of antithrombin III
16) Confidence 0.07 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2270858 Disease Relevance 0.58 Pain Relevance 0.03
Concurrent levels of antithrombin III (AT III), protein C (PC) and protein S (PS) were very low.
Gene_expression (levels) of antithrombin III
17) Confidence 0.07 Published 2001 Journal Leuk. Lymphoma Section Abstract Doc Link 11426567 Disease Relevance 0.77 Pain Relevance 0.13
Urinalysis, and liver and kidney function were normal; antinuclear antibody tests were negative ; platelet count, protein C, protein S, and antithrombin III levels were within normal limits ; and anticardiolipin antibodies and lupus anticoagulant were absent.
Neg (absent) Gene_expression (levels) of antithrombin III in kidney associated with systemic lupus erythematosus
18) Confidence 0.06 Published 2006 Journal Thromb J Section Body Doc Link PMC1764004 Disease Relevance 1.04 Pain Relevance 0.15
Each subject underwent an assay to assess fasting blood levels of fibrinogen, factor VII, antithrombin III (using a chromogenic method), plasminogen tissue activator, beta-thromboglobulin and dimer-D (ELISA method) 24 hours after being admitted to hospital.
Gene_expression (levels) of antithrombin III in blood
19) Confidence 0.06 Published 1991 Journal Minerva Cardioangiol Section Abstract Doc Link 1956544 Disease Relevance 1.07 Pain Relevance 0.15
The mean activity values of the tissue activator inhibitor plasminogen and C-protein, the levels of plasminogen, antithrombin III, and fibrinogen remained unchanged.
Gene_expression (levels) of antithrombin III
20) Confidence 0.06 Published 1993 Journal Kardiologiia Section Abstract Doc Link 8377358 Disease Relevance 0.22 Pain Relevance 0.07

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