INT101474

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 61
Total Number 61
Disease Relevance 38.30
Pain Relevance 10.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
brain 18
optic nerve 16
astrocyte 16
retina 12
spinal cord 6
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 851 100.00 Very High Very High Very High
Neuropathic pain 119 100.00 Very High Very High Very High
cytokine 274 99.74 Very High Very High Very High
cocaine 17 99.36 Very High Very High Very High
Periaqueductal grey 3 99.24 Very High Very High Very High
cva 12 99.08 Very High Very High Very High
Spinal cord 165 98.36 Very High Very High Very High
spinal dorsal horn 8 98.12 Very High Very High Very High
Peripheral nerve injury 7 97.88 Very High Very High Very High
Peripheral nervous system 9 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 960 100.00 Very High Very High Very High
Disease 669 100.00 Very High Very High Very High
Toxocariasis 315 100.00 Very High Very High Very High
Brain Injury 230 100.00 Very High Very High Very High
Neuropathic Pain 147 100.00 Very High Very High Very High
Stab Wounds 30 99.96 Very High Very High Very High
Glaucoma 615 99.84 Very High Very High Very High
Ocular Hypertension 130 99.78 Very High Very High Very High
Hypertrophy 9 99.74 Very High Very High Very High
Urological Neuroanatomy 31 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results show that, compared to control animals, GFAP expression is two-fold enhanced after a single cocaine injection, still significantly higher after seven consecutive daily administrations, but not statistically different after prolonged (14 days) drug treatment.
Positive_regulation (enhanced) of Gene_expression (expression) of GFAP associated with cocaine
1) Confidence 0.70 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882367 Disease Relevance 0 Pain Relevance 0.44
The RT-PCR results indicated an increase in C1q mRNA that was more pronounced than the increased expression of GFAP mRNA ipsilateral to the injury in the dorsal spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of GFAP mRNA in spinal cord associated with injury and spinal cord
2) Confidence 0.70 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19766105 Disease Relevance 0.62 Pain Relevance 0.69
Moreover, SNI animals displayed increased interleukin-1beta (IL-1beta) gene expression within the frontal cortex and concurrent increases in the expression of glial fibrillary acidic protein (GFAP) within the periaqueductal grey (PAG).
Positive_regulation (increases) of Gene_expression (expression) of glial fibrillary acidic protein in frontal cortex associated with nervous system injury, periaqueductal grey and urological neuroanatomy
3) Confidence 0.67 Published 2010 Journal Mol. Psychiatry Section Abstract Doc Link 19773812 Disease Relevance 2.35 Pain Relevance 0.61
Reactive gliosis is another indicator of neuroretinal injury, identified by the upregulation of glial fibrillary acidic protein (GFAP) expression by Muller as well as astrocyte cells.
Positive_regulation (upregulation) of Gene_expression (expression) of glial fibrillary acidic protein in astrocyte associated with injury and gliosis
4) Confidence 0.66 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.75 Pain Relevance 0.06
However, intracamerally inoculated hosts did not demonstrate a significant increase of GFAP expression on day 8 over the negative control.
Positive_regulation (increase) of Gene_expression (expression) of GFAP
5) Confidence 0.66 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.37 Pain Relevance 0
Positive control mice resulted in a twofold increase in GFAP expression on day 8 over the negative control (Figure 5).
Positive_regulation (increase) of Gene_expression (expression) of GFAP
6) Confidence 0.66 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.40 Pain Relevance 0
In addition, significant increases in GFAP expression were observed in the ipsilateral SC at 7 days.
Positive_regulation (increases) of Gene_expression (expression) of GFAP
7) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.25 Pain Relevance 0
Since damage to neuronal cells within the SC was not detected during the period of increased GFAP expression, reactive astrocytes may provide crucial support for neurons during this period through such functions as the production of trophic factors and the elimination of toxins [36,37].
Positive_regulation (increased) of Gene_expression (expression) of GFAP in astrocytes
8) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.20 Pain Relevance 0.03
In the present study, we observed significant increases in BDNF-positive cells in the contralateral SC at 30 and 90 days after NMDA injection, and at least a partial overlap with the cells showing increased expression of GFAP.
Positive_regulation (increased) of Gene_expression (expression) of GFAP
9) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.06 Pain Relevance 0.04
Chronic IOP elevation results in significantly increased GFAP expression in the rat retina and optic nerve [38].
Positive_regulation (results) of Gene_expression (expression) of GFAP in optic nerve associated with ocular hypertension
10) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.42 Pain Relevance 0
Optic nerve head astrocytes demonstrate increased GFAP expression in glaucoma and under conditions of elevated hydrostatic pressure [54].
Positive_regulation (increased) of Gene_expression (expression) of GFAP in Optic nerve head associated with glaucoma
11) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.82 Pain Relevance 0.09
However at 6 months of age, GFAP expression was significantly increased in both retina (Figure 6C) and optic nerve (Figure 6D).
Positive_regulation (increased) of Gene_expression (expression) of GFAP in retina
12) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.39 Pain Relevance 0
Increased GFAP expression in retina and the optic nerve of DBA/2J mice
Positive_regulation (Increased) of Gene_expression (expression) of GFAP in retina
13) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.34 Pain Relevance 0
However, there was cerebral injury, as evidenced by the apparent astrogliosis with enhanced expression of GFAP extending around injured areas where the increases appeared to be correlated with the number of larvae migrating into the brain over time, as seen from 4 to 8 wpi.
Positive_regulation (enhanced) of Gene_expression (expression) of GFAP in brain associated with brain injury
14) Confidence 0.59 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.68 Pain Relevance 0.14
Modulation of astrogliosis with enhanced GFAP expression which is responsible for brain injury in experimental CT was proposed to occur by TGF-?
Positive_regulation (enhanced) of Gene_expression (expression) of GFAP in brain associated with toxocariasis and brain injury
15) Confidence 0.59 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 1.05 Pain Relevance 0.16
Thus, these data show that the cellular expression of GFAP is delayed in the IL-1R1 null mice, but that a compensatory mechanism, such as the delayed production of other cytokines, eventually stimulates GFAP expression to the same level as induced in the wild-type animals [45].


Positive_regulation (stimulates) of Gene_expression (expression) of GFAP associated with cytokine
16) Confidence 0.58 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.77 Pain Relevance 0.09
At 3, 5 and 7 days after stab wound, GFAP expression was increased by stab wound injury in both WT and receptor-null mice.
Positive_regulation (increased) of Gene_expression (expression) of GFAP associated with injury and stab wounds
17) Confidence 0.58 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.55 Pain Relevance 0.03
In the present study, GFAP expression was increased in the contralateral SC at 7, 30, and 90 days after unilateral intravitreal injection of NMDA.
Positive_regulation (increased) of Gene_expression (expression) of GFAP
18) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.27 Pain Relevance 0.03
In our present study, GFAP expression increased dramatically with age in retina and optic nerve of DBA/2J mice.
Positive_regulation (increased) of Gene_expression (expression) of GFAP in optic nerve
19) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.64 Pain Relevance 0.04
However, there was upregulation of GFAP expression one week (C57BL6/J, 5.01 × 103 ± 0.22; iNOS-/-, 4.24 × 103 ± 0.80, p < 0.05) and two weeks (C57BL6/J, 6.01 × 103 ± 0.49; iNOS-/-, 4.76 × 103 ± 0.44, p < 0.01) after sciatic nerve transection (Figure 3Q).
Positive_regulation (upregulation) of Gene_expression (expression) of GFAP in sciatic nerve associated with sciatic nerve
20) Confidence 0.52 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.20 Pain Relevance 0.05

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