INT101475

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 4.77
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 8
brain 6
optic nerve 2
neural 2
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 14 99.56 Very High Very High Very High
Kappa opioid receptor 80 99.06 Very High Very High Very High
Peripheral nervous system 18 95.52 Very High Very High Very High
alcohol 3 94.00 High High
Morphine 2 93.04 High High
Inflammation 40 89.84 High High
Cannabinoid 2 89.24 High High
Nicotine 2 87.80 High High
Spinal cord 55 86.96 High High
medulla 20 85.88 High High
Disease Link Frequency Relevance Heat
Hypertrophy 2 99.74 Very High Very High Very High
Glaucoma 39 99.08 Very High Very High Very High
Brain Injury 60 98.96 Very High Very High Very High
Infection 182 98.74 Very High Very High Very High
Cytomegalovirus Infection 169 98.54 Very High Very High Very High
Toxocariasis 90 97.80 Very High Very High Very High
Nervous System Injury 15 95.80 Very High Very High Very High
Cicatrix 5 94.00 High High
Neurodegenerative Disease 29 90.40 High High
Injury 88 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrate that in mouse dentate gyrus, cocaine exposure differently affects the expression of GFAP and induces strong changes in astrocytes proliferation rate and cell morphology.
Regulation (affects) of Gene_expression (expression) of GFAP in astrocytes associated with cocaine
1) Confidence 0.62 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882367 Disease Relevance 0 Pain Relevance 0.30
On the other hand, we did not observe any change in the expression levels of intracellular GFAP, a marker for astrocytes.
Regulation (change) of Gene_expression (expression) of GFAP in astrocytes
2) Confidence 0.44 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.72 Pain Relevance 0.06
Using an intracellular staining technique and flow cytometry, we found that expression of DCX is altered in the virus-infected brain (Fig. 7A), while GFAP expression remained unaltered (Fig. 7B).
Regulation (unaltered) of Gene_expression (expression) of GFAP in brain
3) Confidence 0.44 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.51 Pain Relevance 0
These activated astrocytes undergo hypertrophy and show up-regulated expression of GFAP (Eng, 1985; Web, 2008), which is thus used as a key indicator of astrocyte activation (Reilly et al., 1997).
Regulation (regulated) of Gene_expression (expression) of GFAP in astrocytes associated with hypertrophy
4) Confidence 0.40 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.48 Pain Relevance 0.29
Modulation of astrogliosis with enhanced GFAP expression which is responsible for brain injury in experimental CT was proposed to occur by TGF-?
Regulation (astrogliosis) of Gene_expression (expression) of GFAP in brain associated with toxocariasis and brain injury
5) Confidence 0.38 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 1.05 Pain Relevance 0.16
A brain specimen from each mouse was separately fixed in 10% neutral buffered formalin for at least 24 h and embedded in paraffin for pathological studies and immunohistochemical detection of GFAP.
Regulation (embedded) of Gene_expression (detection) of GFAP in brain
6) Confidence 0.38 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.09 Pain Relevance 0
HCMV infection of neural progenitor cells in the undifferentiated stage down-regulated GFAP expression while it remained unaltered following infection after differentiation [46].
Regulation (regulated) of Gene_expression (expression) of GFAP in neural associated with cytomegalovirus infection and infection
7) Confidence 0.33 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.79 Pain Relevance 0.10
Quantitative changes in the expression of glial fibrillary acidic protein (GFAP), a cytoskeletal intermediate filament protein exclusively expressed in astrocytes (Bignami et al, 1972), have been observed after administration of alcohol (Framke, 1995), morphine (Beitner-Johnson et al., 1993), amphetamine and its derivates (Aguirre et al., 1999), cannabinoids (Suarez et al., 2000), nicotine (Janson and Moller, 1993), caffeine (Marret et al., 1993) and prenatal exposure to cocaine (Clarke et al., 1996; Nassogne et al., 1998).
Regulation (changes) of Gene_expression (expression) of GFAP in astrocytes associated with nicotine, cannabinoid, cocaine, morphine and alcohol
8) Confidence 0.27 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882367 Disease Relevance 0 Pain Relevance 0.33
Immunoreactivity and mRNA results suggested that the C57BL/6 allele (high Id2/Lpin1 expresser) displayed smaller changes in GFAP expression than did the DBA/2J allele.
Regulation (changes) of Gene_expression (expression) of GFAP
9) Confidence 0.26 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.54 Pain Relevance 0.06
We examined the effects of PEDF transfection on GFAP expression in retina (Figures 9A,C) and optic nerve (Figures 9B,C) of DBA/2J mice at 6 months of age.
Spec (examined) Regulation (effects) of Gene_expression (expression) of GFAP in optic nerve
10) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.36 Pain Relevance 0.08
In contrast, neither KOR-/- nor NorBNI-treated mice showed significant changes in the expression pattern of GFAP-IR between ipsilateral and contralateral side of TREZ (Fig. 4D, E, F).
Regulation (changes) of Gene_expression (expression) of GFAP-IR associated with kappa opioid receptor
11) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.23 Pain Relevance 0.57

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