INT101477

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.42
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADORA1) endoplasmic reticulum (ADORA1) plasma membrane (ADORA1)
cell-cell signaling (ADORA1) signal transducer activity (ADORA1)
ADORA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 192 100.00 Very High Very High Very High
agonist 153 99.96 Very High Very High Very High
c fibre 3 99.48 Very High Very High Very High
antagonist 72 99.30 Very High Very High Very High
nMDA receptor antagonist 1 98.40 Very High Very High Very High
Pyramidal cell 6 98.20 Very High Very High Very High
Antinociceptive 2 96.76 Very High Very High Very High
Calcium channel 7 86.32 High High
Kinase C 4 82.20 Quite High
unmyelinated 1 77.24 Quite High
Disease Link Frequency Relevance Heat
Disease 7 95.52 Very High Very High Very High
Asthma 9 93.92 High High
Bordatella Infection 1 84.16 Quite High
Increased Venous Pressure Under Development 10 74.32 Quite High
Pressure Volume 2 Under Development 3 19.76 Low Low
Pain 6 13.24 Low Low
Cv Unclassified Under Development 9 12.88 Low Low
Injury 2 12.44 Low Low
Cancer 6 11.56 Low Low
INFLAMMATION 15 10.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interactions between adenosine receptor ligands and dizocilpine (uncompetitive NMDA receptor antagonist) was studied in antinociceptive, writhing test in mice.
adenosine receptor Binding (Interactions) of associated with nmda receptor antagonist, adenocard and antinociceptive
1) Confidence 0.31 Published 2005 Journal Int. J. Neurosci. Section Abstract Doc Link 15809217 Disease Relevance 0 Pain Relevance 0.73
Some members of this series also had a competitive interaction with the A1 adenosine receptor [39, 40].
adenosine receptor Binding (interaction) of associated with adenocard
2) Confidence 0.06 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.32
Their allosteric-enhancing nature was identified by accident while screening the library in a radioligand-binding assay at the rat A1 adenosine receptor.
adenosine receptor Binding (binding) of associated with adenocard
3) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.31
The compounds were shown to bind the adenosine A1 receptor (Ki-binding values ranging from 2.3 to 30.5 nM) and to activate the adenosine A2B AR (EC50 values ranging from 7.3 to 175 nM) in the low nanomolar range, displaying at the same time a considerable level of selectivity toward A2A AR subtypes (Ki?
adenosine A1 receptor Binding (bind) of associated with adenocard
4) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0 Pain Relevance 0.17
The adenosine A1 receptor (A1R) is known to regulate Ca2+/K+ channels, adenylate cyclase, and phospholipase C by coupling to Gi/o proteins [1].
adenosine A1 receptor Binding (coupling) of associated with adenocard
5) Confidence 0.04 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.13
The latter responded to both P2X receptor and adenosine receptor agonists.
adenosine receptor Binding (responded) of associated with adenocard and agonist
6) Confidence 0.04 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882377 Disease Relevance 0 Pain Relevance 0.62
Xanthines, including the natural derivatives theophylline and caffeine, are the natural non-selective antagonists of adenosine and they are able to bind to all four adenosine receptor subtypes A1, A2A, A2B and A3 [6].
adenosine receptor Binding (bind) of associated with adenocard and antagonist
7) Confidence 0.03 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0 Pain Relevance 0.52
Aminophylline exerts multiple pharmacological effects either through phosphodiesterase inhibition or via adenosine receptor blockage (22, 23).
adenosine receptor Binding (blockage) of associated with adenocard
8) Confidence 0.02 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.42 Pain Relevance 0.27

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