INT101481

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 81
Total Number 81
Disease Relevance 62.59
Pain Relevance 9.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 8
fat 5
body 3
brain 2
cartilage 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 33 99.98 Very High Very High Very High
Intracerebroventricular 17 99.96 Very High Very High Very High
Osteoarthritis 544 99.64 Very High Very High Very High
long-term potentiation 170 99.60 Very High Very High Very High
Inflammatory stimuli 20 99.16 Very High Very High Very High
Inflammation 472 98.80 Very High Very High Very High
Action potential 28 98.80 Very High Very High Very High
tolerance 57 98.64 Very High Very High Very High
cytokine 412 97.68 Very High Very High Very High
nMDA receptor 321 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 3153 100.00 Very High Very High Very High
Body Weight 297 100.00 Very High Very High Very High
Diabetes Mellitus 341 99.98 Very High Very High Very High
Stress 258 99.96 Very High Very High Very High
Abdominal Obesity 17 99.88 Very High Very High Very High
Asthma 731 99.84 Very High Very High Very High
Lifespan 116 99.84 Very High Very High Very High
Pre-eclampsia 650 99.82 Very High Very High Very High
Osteoarthritis 464 99.64 Very High Very High Very High
Insulin Resistance 128 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leptin, an adipokine with proinflammatory activity, was increased systemically in high-fat-fed mice following a pattern that was similar to the temporal changes in body mass (Figure 5a).
Positive_regulation (increased) of Leptin in fat
1) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.57 Pain Relevance 0.45
RESULTS: Kinin B(1) receptor deficiency in mice (B(1)(-/-)) resulted in less fat content, hypoleptinemia, increased leptin sensitivity, and robust protection against high-fat diet-induced weight gain.
Positive_regulation (increased) of leptin in fat
2) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link 18332096 Disease Relevance 0 Pain Relevance 0
Although it is likely that leptin promotes activation of MAPK via stimulation of the ubiquitous Ras-Raf pathway (Blenis, 1993), the possibility that a distinct upstream pathway couples leptin receptor activation to MEK/MAPK stimulation cannot be excluded as leptin is able to trigger the MAPK cascade via either tyrosine phosphorylation of the JAK2-receptor complex or independently of receptor phosphorylation (Bjorbaek et al., 2001).
Positive_regulation (activation) of leptin
3) Confidence 0.66 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.17
Indeed, leptin-induced an increase in the number of actin-rich spines, which parallels the morphological change that accompany hippocampal LTP (Fukazawa et al., 2003).
Positive_regulation (increase) of leptin-induced in spines associated with long-term potentiation
4) Confidence 0.66 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.21
Interestingly, the corticosterone implants also significantly increased serum insulin and leptin (Fig. 5B and 5C).
Positive_regulation (increased) of leptin
5) Confidence 0.64 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.72 Pain Relevance 0
Sensitized wild-type mice challenged with ovalbumin developed increased serum leptin, consistent with a recent report that for comparable BMI, leptin is increased in asthmatic compared with healthy boys (Guler et al. 2004).
Positive_regulation (increased) of leptin associated with asthma and obesity
6) Confidence 0.62 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 1.70 Pain Relevance 0.23
Increases in serum leptin observed in obesity may contribute to the increased incidence of asthma in the obese because leptin, a member of the IL-6 family of cytokines, has pro-inflammatory effects.
Positive_regulation (Increases) of leptin associated with asthma, inflammation, obesity and cytokine
7) Confidence 0.62 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 1.72 Pain Relevance 0.25
More specifically, leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae [47] and in diabetic patients' neutrophils, an increase in leptin serum levels has been correlated with the degree of CD11b expression [48].
Positive_regulation (increase) of leptin in neutrophil associated with diabetes mellitus
8) Confidence 0.61 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.33 Pain Relevance 0.18
There was also a small but detectable and reproducible increase in insulin content in ob/ob pancreata (Fig.
Positive_regulation (increase) of ob
9) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.76 Pain Relevance 0
There was also a small but detectable and reproducible increase in insulin content in ob/ob pancreata (Fig.
Positive_regulation (increase) of ob
10) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.76 Pain Relevance 0
A significant proportion of obese patients have elevated leptin levels, suggesting a build up of tolerance toward its effects (ie, leptin resistance).
Positive_regulation (elevated) of leptin associated with obesity and tolerance
11) Confidence 0.53 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.33 Pain Relevance 0.05
Plasma leptin levels are significantly elevated in pregnant women with PE and the increase in plasma leptin levels is correlated with the severity of preeclampsia [14].
Positive_regulation (elevated) of leptin in plasma associated with pre-eclampsia
12) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.48 Pain Relevance 0
Plasma leptin levels are significantly elevated in pregnant women with PE and the increase in plasma leptin levels is correlated with the severity of preeclampsia [14].
Positive_regulation (increase) of leptin in plasma associated with pre-eclampsia
13) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.52 Pain Relevance 0
The fact that leptin did not affect mouse trophoblasts growth in cell culture suggests that the increased levels of leptin observed in our PE model is rather a compensatory mechanism to maintain trophoblasts growth than the cause of trophoblast defective invasiveness.
Positive_regulation (increased) of leptin associated with pre-eclampsia
14) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.67 Pain Relevance 0.03
However we could not identify the source of the increased leptin levels.
Positive_regulation (increased) of leptin
15) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.60 Pain Relevance 0
In agouti obese mice and lean controls, we tested the effects of single intracerebroventricular (ICV) injection of leptin or vehicle on food intake and body weight in the conscious state and on renal sympathetic nerve activity during anesthesia.
Positive_regulation (injection) of leptin in body associated with anesthesia, body weight, obesity and intracerebroventricular
16) Confidence 0.50 Published 2002 Journal Hypertension Section Abstract Doc Link 11882595 Disease Relevance 0.73 Pain Relevance 0.30
production, we evaluated the leptin receptor Ob-R, the post-leptin receptor
                   signaling molecule STAT-3 and STAT-3 phosphorylation. 
Positive_regulation (evaluated) of leptin
17) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.88 Pain Relevance 0
M; 30 min) had no effect on the density of filopodia per se (mean density of 2.39 ± 0.51; n = 9; P > 0.05), and it did not significantly attenuate the leptin-induced increase in the number of filopodia (mean density of 5.69 ± 0.76; n = 9; P < 0.05; Fig. 4D).
Positive_regulation (increase) of leptin-induced
18) Confidence 0.48 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.26
The effect of leptin (50 nM) occurred rapidly as a significant increase in filopodial density (to 206 ± 14% of control; mean density of 5.45 ± 0.36; n = 10; P < 0.01) was evident after 10 min incubation with leptin, with a peak increase (to 544 ± 95% of control; mean density of 13.8 ± 2.3; n = 12; P < 0.01) detected after 3 h exposure (Fig. 1D).
Positive_regulation (incubation) of leptin
19) Confidence 0.48 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
A MAPK-dependent process underlies leptin-induced increase in dendritic filopodia
Positive_regulation (increase) of leptin-induced
20) Confidence 0.48 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.31

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