INT101482

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Context Info
Confidence 0.54
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 53
Total Number 55
Disease Relevance 33.59
Pain Relevance 5.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 7
fat 3
body 3
immune system 2
sympathetic nervous system 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 16 99.00 Very High Very High Very High
Cholecystokinin 104 98.72 Very High Very High Very High
cytokine 313 98.60 Very High Very High Very High
Osteoarthritis 110 97.24 Very High Very High Very High
Inflammatory stimuli 20 96.28 Very High Very High Very High
nMDA receptor 41 94.52 High High
Enkephalin 5 94.40 High High
medulla 54 90.00 High High
methadone 156 89.20 High High
GABAergic 4 89.08 High High
Disease Link Frequency Relevance Heat
Obesity 2324 100.00 Very High Very High Very High
Anorexia 17 100.00 Very High Very High Very High
Lifespan 58 99.84 Very High Very High Very High
Body Weight 431 99.76 Very High Very High Very High
Primary Sclerosing Cholangitis 4 99.72 Very High Very High Very High
Targeted Disruption 146 99.58 Very High Very High Very High
Diabetes Mellitus 570 99.50 Very High Very High Very High
Opiate Addiction 8 99.28 Very High Very High Very High
Scoliosis 1570 98.76 Very High Very High Very High
Weight Gain 33 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As with fasting, the reduction in plasma leptin could largely be a reflection of the reduction in adipose weight, as well as plasma insulin.
Negative_regulation (reduction) of leptin in plasma
1) Confidence 0.54 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.21 Pain Relevance 0
Since adrenalectomy blocked the fasting-induced reduction in melanocortin tone in diabetic mice (as it had in euglycemic mice in the first study), these results suggest that effects of fasting on melanocortin tone in diabetic mice may be mediated at least in part by a rise in plasma corticosterone (itself possibly secondary to the reduction in plasma leptin).
Spec (possibly) Negative_regulation (reduction) of leptin in plasma associated with diabetes mellitus
2) Confidence 0.54 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.27 Pain Relevance 0
In turn, as with fasting, the reduction of plasma leptin could be the cause of the elevation of hypothalamic AGRP and NPY mRNA, as well as the reduction of hypothalamic POMC mRNA.
Negative_regulation (reduction) of leptin in plasma
3) Confidence 0.54 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.16 Pain Relevance 0
In summary, this study indicates that selective leptin resistance in agouti obese mice occurs with central neural administration of leptin, suggesting that selective leptin resistance in this model is not due to a defect in leptin transport across the blood brain barrier.
Negative_regulation (defect) of leptin in brain associated with obesity
4) Confidence 0.43 Published 2002 Journal Hypertension Section Abstract Doc Link 11882595 Disease Relevance 0.75 Pain Relevance 0.29
Further
               evidence from our lab as well as others also indicated that leptin deficiency
               paradoxically triggers cardiac hypertrophy and contractile dysfunction in
                   ob/ob obese mice with a mutant leptin gene, the effect of which
               is reconciled by leptin supplementation [12], [15]. 
Negative_regulation (deficiency) of leptin associated with obesity and coronary heart disease
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.17 Pain Relevance 0
First and foremost, the short-term
                   in vitro leptin incubation used in our study may not best
               represent the in vivo longer term effect of leptin on phenotypic
               changes in obesity. 
Negative_regulation (effect) of leptin associated with obesity
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.07 Pain Relevance 0
For example, recent studies have shown that mice deficient in leptin or the leptin receptor undergo extreme weight gain but exhibit no changes in osteoarthritis [76].
Negative_regulation (deficient) of leptin associated with weight gain and osteoarthritis
7) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.73 Pain Relevance 0.31
M; 30 min) failed to prevent leptin-induced morphogenesis, as leptin increased the density of filopodia to 6.63 ± 0.57 (n = 9; P < 0.01; Figs. 4C, D) in the presence of ifenprodil.
Negative_regulation (prevent) of leptin-induced
8) Confidence 0.40 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0.14 Pain Relevance 0.37
Fasting and diabetes are characterized by elevated glucocorticoids and reduced insulin, leptin, elevated hypothalamic AGRP and NPY mRNA, and reduced hypothalamic POMC mRNA.
Negative_regulation (reduced) of leptin associated with diabetes mellitus
9) Confidence 0.40 Published 2003 Journal BMC Physiol Section Abstract Doc Link PMC179893 Disease Relevance 0.44 Pain Relevance 0
On the other hand, blocking the rise in corticosterone by adrenalectomy prevented the reduction in hypothalamic POMC mRNA and the induction of AGRP mRNA, without reversing either the reduced leptin or the reduced adiposity, characteristic of insulin-deficient diabetic mice (Fig. 4A and 4B).
Negative_regulation (reduced) of leptin associated with diabetes mellitus
10) Confidence 0.40 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.23 Pain Relevance 0
For example, it is clear that the regulation of AGRP differs in rats and mice, since in mice hypothalamic AGRP mRNA is elevated by a deficiency in leptin receptor function [4] but in rats this is not true [21].
Negative_regulation (deficiency) of leptin
11) Confidence 0.40 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.27 Pain Relevance 0
Since both fasting and insulin deficiency are associated with reduced plasma leptin [5], and leptin replacement reverses effects of fasting [6] and also effects of insulin deficiency on food intake and body weight [7], it has been suggested that the reduction in leptin accounts for the reduced hypothalamic melanocortin tone in these conditions.
Negative_regulation (reduced) of leptin in plasma associated with body weight
12) Confidence 0.40 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.17 Pain Relevance 0
Although a reduction in plasma leptin plays an important role in mediating neuroendocrine responses to fasting [6] and diabetes [17], we have previously demonstrated that fasting can regulate hypothalamic melanocortin tone independently of both leptin and insulin [5].
Negative_regulation (reduction) of leptin in plasma associated with diabetes mellitus
13) Confidence 0.40 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.19 Pain Relevance 0
Serum leptin was also reduced to the same levels in all experimental groups compared to control mice (Fig. 3C).
Negative_regulation (reduced) of leptin
14) Confidence 0.40 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.68 Pain Relevance 0
Thus fasting [3,4], insulin deficiency [5], and leptin deficiency [4] are all associated with reduced hypothalamic melanocortin tone.
Negative_regulation (deficiency) of leptin
15) Confidence 0.40 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.16 Pain Relevance 0
Since both fasting and insulin deficiency are associated with reduced plasma leptin [5], and leptin replacement reverses effects of fasting [6] and also effects of insulin deficiency on food intake and body weight [7], it has been suggested that the reduction in leptin accounts for the reduced hypothalamic melanocortin tone in these conditions.
Negative_regulation (reduction) of leptin in plasma associated with body weight
16) Confidence 0.40 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.23 Pain Relevance 0
Glucocorticoids were also elevated, as expected, in insulin-deficient diabetes (Fig. 3A), and serum insulin, leptin and melanocortin tone were also reduced in this condition (Fig. 3B and 3C, 4A and 4B).
Negative_regulation (reduced) of leptin associated with diabetes mellitus
17) Confidence 0.39 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.21 Pain Relevance 0
These data suggest that in fasting and insulin-deficient diabetes, as in leptin-deficient ob/ob mice [9,19], glucocorticoids dominate leptin and insulin levels in determining AGRP expression, whereas insulin and leptin dominate glucocorticoids in determining hypothalamic POMC expression.
Negative_regulation (dominate) of leptin associated with diabetes mellitus and obesity
18) Confidence 0.39 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.45 Pain Relevance 0
Gene variants that may impact the biology of AIS pathogenesis [56] are considered here in relation to body mass index (BMI), timing of puberty, leptin, leptin-receptor deficiency, changes in hypothalamic resistance/sensitivity to leptin, some hormones thought to be related to AIS pathogenesis, and certain genetically-modified mice.
Negative_regulation (deficiency) of leptin in body associated with scoliosis and obesity
19) Confidence 0.39 Published 2009 Journal Scoliosis Section Body Doc Link PMC2781798 Disease Relevance 0.69 Pain Relevance 0
Gene variants that may impact the biology of AIS pathogenesis [56] are considered here in relation to body mass index (BMI), timing of puberty, leptin, leptin-receptor deficiency, changes in hypothalamic resistance/sensitivity to leptin, some hormones thought to be related to AIS pathogenesis, and certain genetically-modified mice.
Negative_regulation (deficiency) of leptin in body associated with scoliosis and obesity
20) Confidence 0.39 Published 2009 Journal Scoliosis Section Body Doc Link PMC2781798 Disease Relevance 0.69 Pain Relevance 0

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