INT101484

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
body 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 7 100.00 Very High Very High Very High
nMDA receptor 32 98.60 Very High Very High Very High
cytokine 2 95.76 Very High Very High Very High
anesthesia 2 95.48 Very High Very High Very High
Hippocampus 10 76.56 Quite High
Glutamate receptor 1 62.72 Quite High
long-term potentiation 17 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 182 100.00 Very High Very High Very High
Body Weight 10 98.76 Very High Very High Very High
Aging 124 98.48 Very High Very High Very High
Anorexia 1 90.92 High High
Stress 17 50.00 Quite Low
Disseminated Intravascular Coagulation 8 27.00 Quite Low
Diabetes Mellitus 7 5.00 Very Low Very Low Very Low
Lifespan 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agouti obese mice and lean controls, we tested the effects of single intracerebroventricular (ICV) injection of leptin or vehicle on food intake and body weight in the conscious state and on renal sympathetic nerve activity during anesthesia.
Regulation (effects) of Positive_regulation (injection) of leptin in body associated with anesthesia, body weight, obesity and intracerebroventricular
1) Confidence 0.45 Published 2002 Journal Hypertension Section Abstract Doc Link 11882595 Disease Relevance 0.74 Pain Relevance 0.30
A MAPK-dependent process underlies leptin-induced increase in dendritic filopodia
Regulation (dependent) of Positive_regulation (increase) of leptin-induced
2) Confidence 0.43 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.31
Influence of age and ob/ob obesity on leptin receptor (Ob-R)
                   and STAT3 activation
Regulation (Influence) of Positive_regulation (activation) of leptin associated with obesity
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.94 Pain Relevance 0

General Comments

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