INT101493

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 6
Total Number 6
Disease Relevance 2.18
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl3) signal transducer activity (F2rl3)
Anatomy Link Frequency
joint 3
vasculature 1
F2rl3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 7 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
Inflammation 3 98.12 Very High Very High Very High
ischemia 4 97.68 Very High Very High Very High
b2 receptor 3 97.56 Very High Very High Very High
c fibre 6 93.88 High High
dorsal root ganglion 4 82.76 Quite High
chemokine 2 71.96 Quite High
opioid receptor 2 62.68 Quite High
Somatostatin 2 61.88 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 6 98.92 Very High Very High Very High
INFLAMMATION 3 98.12 Very High Very High Very High
Coronary Artery Disease 2 98.12 Very High Very High Very High
Cv Unclassified Under Development 2 97.32 Very High Very High Very High
Reperfusion Injury 2 96.96 Very High Very High Very High
Injury 6 96.60 Very High Very High Very High
Nociception 6 91.28 High High
Ganglion Cysts 4 82.28 Quite High
Adhesions 17 37.76 Quite Low
Pain 1 19.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteinase-activated receptor-4 (PAR4) activation leads to sensitization of rat joint primary afferents via a bradykinin B2 receptor-dependent mechanism.
Positive_regulation (activation) of PAR4 in joint associated with pain and b2 receptor
1) Confidence 0.45 Published 2010 Journal J. Neurophysiol. Section Title Doc Link 19889854 Disease Relevance 0.34 Pain Relevance 0.45
Proteinase-activated receptor-4 (PAR4) activation leads to sensitization of rat joint primary afferents via a bradykinin B2 receptor-dependent mechanism.
Positive_regulation (activation) of Proteinase-activated receptor-4 in joint associated with pain and b2 receptor
2) Confidence 0.41 Published 2010 Journal J. Neurophysiol. Section Title Doc Link 19889854 Disease Relevance 0.34 Pain Relevance 0.45
The G-protein-linked receptor, proteinase-activated receptor-4 (PAR(4)) is activated by proteinases released into the joint during inflammation.
Positive_regulation (activated) of proteinase-activated receptor-4 in joint associated with inflammation
3) Confidence 0.41 Published 2010 Journal J. Neurophysiol. Section Abstract Doc Link 19889854 Disease Relevance 0.34 Pain Relevance 0.13
Activation of protease-activated receptor (PAR)-2 has been proposed to be protective in myocardial ischemia/reperfusion (I/R) injury, an effect possibly related to an action on the coronary vasculature.
Positive_regulation (Activation) of protease-activated receptor in vasculature associated with coronary artery disease, ischemia and injury
4) Confidence 0.29 Published 2002 Journal Circ. Res. Section Abstract Doc Link 11884377 Disease Relevance 0.54 Pain Relevance 0.16
Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers.
Positive_regulation (activation) of Protease-activated receptor associated with c fibre, reperfusion injury, qutenza, ischemia and increased venous pressure under development
5) Confidence 0.21 Published 2002 Journal Circ. Res. Section Title Doc Link 11884377 Disease Relevance 0.62 Pain Relevance 0.42
The remaining 14 Rhodopsins (black) are scattered in smaller groups of ligand types including protease-activated (F2R, F2RL1, F2RL2 and mF2RL3), glycoprotein hormone (FSHR, LHCGR and TSHR), metabolite (OXGR1, GPR35, SUCNR1, GPR109A and GPR109B), amino acid (MRGPRD) and steroid hormone (estrogen receptor GPR30).
Positive_regulation (activated) of mF2RL3
6) Confidence 0.00 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2117022 Disease Relevance 0 Pain Relevance 0.19

General Comments

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