INT101494

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 18
Total Number 22
Disease Relevance 6.57
Pain Relevance 12.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
dorsal root ganglion 4
nociceptors 4
blood 2
juvenile 2
endothelium 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 363 100.00 Very High Very High Very High
vanilloid receptor subtype 1 2 100.00 Very High Very High Very High
Endocannabinoid 27 99.98 Very High Very High Very High
Dopamine 10 99.98 Very High Very High Very High
Pain 93 99.90 Very High Very High Very High
Inflammation 59 99.90 Very High Very High Very High
Calcitonin gene-related peptide 116 99.84 Very High Very High Very High
Nerve growth factor 108 99.62 Very High Very High Very High
Kinase C 69 99.16 Very High Very High Very High
c fibre 5 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 29 99.06 Very High Very High Very High
Nociception 58 98.96 Very High Very High Very High
Hyperalgesia 53 98.68 Very High Very High Very High
Ganglion Cysts 218 98.36 Very High Very High Very High
Increased Venous Pressure Under Development 3 98.36 Very High Very High Very High
Neuropathic Pain 52 98.00 Very High Very High Very High
Fever 17 97.28 Very High Very High Very High
Inflammatory Pain 14 94.76 High High
INFLAMMATION 53 93.04 High High
Stress 5 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Using the TRPV1 agonists capsaicin and resiniferatoxin and selective antagonists capsazepine and SB366791, we examined the effect of TRPV1 activation on LTP and LTD in hippocampal CA1 slices of juvenile rats.
Spec (examined) Regulation (effect) of Spec (examined) Positive_regulation (activation) of TRPV1 in juvenile
1) Confidence 0.62 Published 2008 Journal Biol. Psychiatry Section Body Doc Link 18405883 Disease Relevance 0.09 Pain Relevance 0
We next examined the molecular target of DAG on TRPV1 activation.
Spec (examined) Regulation (target) of Spec (examined) Positive_regulation (activation) of TRPV1
2) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 0.45
Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on primary nociceptors.
Regulation (effects) of Positive_regulation (activation) of vanilloid receptor 1 in nociceptors associated with qutenza and nociceptor
3) Confidence 0.45 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721338 Disease Relevance 0.08 Pain Relevance 0.62
Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on primary nociceptors.
Regulation (effects) of Positive_regulation (activation) of VR1 in nociceptors associated with qutenza and nociceptor
4) Confidence 0.45 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721338 Disease Relevance 0.08 Pain Relevance 0.62
It has been proposed that activation of vanilloid receptor-1 (TRPV1) affects the vasotone of resistance arteries.
Regulation (affects) of Positive_regulation (activation) of vanilloid receptor-1
5) Confidence 0.45 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16338989 Disease Relevance 0 Pain Relevance 0.16
It has been proposed that activation of vanilloid receptor-1 (TRPV1) affects the vasotone of resistance arteries.
Regulation (affects) of Positive_regulation (activation) of TRPV1
6) Confidence 0.45 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16338989 Disease Relevance 0 Pain Relevance 0.16
Thus, in the present work, we set out to evaluate the possibility of TRPV1 activation by DAG.


Spec (possibility) Regulation (possibility) of Positive_regulation (activation) of TRPV1
7) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.68 Pain Relevance 0.58
Both the NGF- and GDNF-induced upregulation of TRPV1 appears to be translationally regulated, as neither of these growth factors altered TRPV1 mRNA levels.
Spec (appears) Regulation (regulated) of Positive_regulation (upregulation) of TRPV1 associated with nerve growth factor
8) Confidence 0.42 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.58 Pain Relevance 0.71
Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: a potential mechanism of inflammatory pain.
Regulation (regulation) of Positive_regulation (activation) of Trpv1 in dorsal root ganglion associated with ganglion cysts, inflammation, ipn, root ganglion neuron and calcitonin gene-related peptide
9) Confidence 0.42 Published 2010 Journal Mol. Biol. Cell Section Title Doc Link 20534813 Disease Relevance 1.08 Pain Relevance 1.81
Thereafter, the potentiation of TRPV1 could be responsible for the excitation, and for the hyperalgesia and allodynia seen after ET-1 application.
Regulation (responsible) of Positive_regulation (potentiation) of TRPV1 associated with hyperalgesia and allodynia
10) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.49 Pain Relevance 0.75
Role of protein kinases in the ETA receptor-mediated potentiation of TRPV1
Regulation (Role) of Positive_regulation (potentiation) of TRPV1
11) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.12
We found that profile C modulator, (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)acrylamide (AMG8562), blocks capsaicin activation of TRPV1, does not affect heat activation of TRPV1, potentiates pH 5 activation of TRPV1 in vitro, and does not cause hyperthermia in vivo in rats.
Neg (not) Regulation (affect) of Neg (not) Positive_regulation (activation) of TRPV1 associated with qutenza and fever
12) Confidence 0.27 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18420600 Disease Relevance 0.77 Pain Relevance 0.72
These results support the idea that coexpression of VR.5'sv or a similar variant could result in inhibitory modulation of TRPV1 activation.
Regulation (modulation) of Positive_regulation (activation) of TRPV1
13) Confidence 0.27 Published 2007 Journal Neuroreport Section Abstract Doc Link 17558279 Disease Relevance 0.17 Pain Relevance 0.22
AMG8562 blocks capsaicin activation of TRPV1 receptor, does not affect heat activation of TRPV1 receptor, potentiates pH 5 activation of TRPV1 receptor in vitro, and does not cause hyperthermia in vivo in rats.
Neg (not) Regulation (affect) of Positive_regulation (activation) of TRPV1 receptor associated with qutenza and fever
14) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.65 Pain Relevance 0.50
These results with mutant analysis suggest that PKC phosphorylation does not play a critical role in the induction of TRPV1 activation by 100 ?
Neg (not) Regulation (role) of Positive_regulation (induction) of TRPV1 associated with kinase c
15) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 0.99
Through their co-expression and formation of heteromeric complexes with TRPV1, they have been shown to modulate TRPV1 activation.
Regulation (modulate) of Positive_regulation (activation) of TRPV1
16) Confidence 0.27 Published 2010 Journal Front. Biosci. Section Abstract Doc Link 20515731 Disease Relevance 0.39 Pain Relevance 0.36
The activation of transient receptor potential vanilloid receptor subtype 1 by capsaicin without extracellular Ca2+ is involved in the mechanism of distinct substance P release in cultured rat dorsal root ganglion neurons.
Regulation (involved) of Positive_regulation (activation) of vanilloid receptor subtype 1 in dorsal root ganglion associated with ganglion cysts, vanilloid receptor subtype 1, qutenza, root ganglion neuron and substance p
17) Confidence 0.26 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 18034335 Disease Relevance 0.35 Pain Relevance 1.35
Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet.
Regulation (regulates) of Positive_regulation (activation) of vanilloid type 1 in blood associated with endocannabinoid
18) Confidence 0.23 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17308041 Disease Relevance 0 Pain Relevance 0.53
These data suggest that the extent to which exogenous N-arachidonoyl-dopamine activates VR1 receptor in isolated organs is largely dependent on pharmacodynamics and bioavailability.
Regulation (dependent) of Positive_regulation (activates) of VR1 receptor associated with dopamine and bioavailability
19) Confidence 0.23 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12954366 Disease Relevance 0 Pain Relevance 0.80
This study shows, for the first time, that PAR2 activation causes endothelium-dependent coronary vasodilation that is preserved after I/R injury and is not mediated by NO or prostanoids, but involves the release of an endothelium-derived hyperpolarizing factor (EDHF), possibly a lipoxygenase-derived eicosanoid, and activation of VR1 receptors on sensory C-fibers.
Neg (not) Regulation (involves) of Positive_regulation (activation) of VR1 in endothelium associated with c fibre, injury and increased venous pressure under development
20) Confidence 0.17 Published 2002 Journal Circ. Res. Section Abstract Doc Link 11884377 Disease Relevance 0.47 Pain Relevance 0.42

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