INT101497

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Context Info
Confidence 0.81
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 2.55
Pain Relevance 5.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkce) mitochondrion (Prkce) endoplasmic reticulum (Prkce)
plasma membrane (Prkce) nucleus (Prkce) enzyme binding (Prkce)
Prkce (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 19 99.64 Very High Very High Very High
Morphine 18 99.24 Very High Very High Very High
nMDA receptor 12 99.20 Very High Very High Very High
Kinase C 24 98.86 Very High Very High Very High
qutenza 13 98.68 Very High Very High Very High
antagonist 6 93.40 High High
imagery 4 92.92 High High
Root ganglion neuron 6 90.60 High High
bradykinin 6 90.56 High High
Serotonin 1 82.64 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.96 Very High Very High Very High
Pain 10 99.64 Very High Very High Very High
Reperfusion Injury 2 98.32 Very High Very High Very High
Nociception 10 96.04 Very High Very High Very High
Coronary Artery Disease 1 93.96 High High
Ganglion Cysts 14 90.28 High High
Injury 5 85.52 High High
INFLAMMATION 2 75.92 Quite High
Diabetes Mellitus 1 75.56 Quite High
Inflammatory Pain 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of PKCepsilon and TRPV1 and the cellular translocation of PKCepsilon from cytosol to membrane compartments were assessed by immunoblot analysis.
Phosphorylation (Phosphorylation) of PKCepsilon
1) Confidence 0.81 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.09 Pain Relevance 0
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Phosphorylation (phosphorylation) of PKCepsilon
2) Confidence 0.81 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
In cells transfected with tagged PKCepsilon, hydrogen peroxide induced translocation and a reduction in free sulfhydryls of full-length PKCepsilon but not of the deletion mutant lacking the C1A domain.
Phosphorylation (sulfhydryls) of PKCepsilon
3) Confidence 0.72 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18799680 Disease Relevance 0.48 Pain Relevance 0.68
Phosphorylation of PKCepsilon and TRPV1 and the cellular translocation of PKCepsilon from cytosol to membrane compartments were assessed by immunoblot analysis.
Phosphorylation (Phosphorylation) of PKCepsilon
4) Confidence 0.62 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.09 Pain Relevance 0
DISCUSSION: Our results indicate that propofol modulates TRPV1 sensitivity to capsaicin and that this most likely occurs through a PKCepsilon-mediated phosphorylation of TRPV1.


Phosphorylation (phosphorylation) of PKCepsilon
5) Confidence 0.62 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0 Pain Relevance 0
Morphine pretreatment significantly inhibited nPKCepsilon membrane translocation and phosphorylation of NR1 subunits of NMDA receptors during reperfusion injury.
Phosphorylation (phosphorylation) of nPKCepsilon associated with reperfusion injury, nmda receptor and morphine
6) Confidence 0.53 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.17 Pain Relevance 1.00
At designated periods, slices were preserved for immunoblot analysis to observe effects of morphine pretreatment on membrane translocation and total protein expression of nPKCepsilon and phosphorylation of NR1 subunits of NMDA receptors.
Phosphorylation (phosphorylation) of nPKCepsilon associated with nmda receptor and morphine
7) Confidence 0.53 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.15 Pain Relevance 0.98
Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800.
Phosphorylation (phosphorylation) of PKCepsilon associated with qutenza
8) Confidence 0.48 Published 2006 Journal Pain Section Title Doc Link 16564619 Disease Relevance 0.18 Pain Relevance 0.36
TRPV1 has two putative substrates S502 and S800 for PKCepsilon-mediated phosphorylation.
Phosphorylation (phosphorylation) of PKCepsilon
9) Confidence 0.48 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.17 Pain Relevance 0.26
Direct phosphorylation of TRPV1 by PKC epsilon was confirmed and the involved two serine residues were determined.
Phosphorylation (phosphorylation) of PKC epsilon
10) Confidence 0.36 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884755 Disease Relevance 0.60 Pain Relevance 1.25
PKC-dependent myristoylated alanine-rich C kinase substrate phosphorylation in epsilonPKC knock-out cells revealed that only a subset of the peptides were selective for epsilonPKC over other PKC isozymes.
Phosphorylation (phosphorylation) of epsilonPKC associated with targeted disruption and kinase c
11) Confidence 0.33 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142835 Disease Relevance 0.43 Pain Relevance 0.45
An in vitro kinase assay using glutathione S-transferase fusion proteins with cytoplasmic segments of VR1 showed that both the first intracellular loop and carboxyl terminus of VR1 were phosphorylated by PKCepsilon.
Phosphorylation (phosphorylated) of PKCepsilon
12) Confidence 0.10 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11884385 Disease Relevance 0.15 Pain Relevance 0.60

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