INT101506

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 7.34
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tst) RNA binding (Tst) plasma membrane (Tst)
Anatomy Link Frequency
face 1
Tst (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 62 100.00 Very High Very High Very High
depression 203 99.98 Very High Very High Very High
agonist 83 99.80 Very High Very High Very High
narcan 1 99.08 Very High Very High Very High
monoamine 77 98.92 Very High Very High Very High
antidepressant 139 98.68 Very High Very High Very High
opioid receptor 1 97.44 Very High Very High Very High
antagonist 9 96.80 Very High Very High Very High
GABAergic 31 96.32 Very High Very High Very High
fluoxetine 18 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 248 99.98 Very High Very High Very High
Stress 81 99.58 Very High Very High Very High
Sprains And Strains 838 99.12 Very High Very High Very High
Targeted Disruption 44 96.86 Very High Very High Very High
Depressive Disorder 24 96.84 Very High Very High Very High
Anxiety Disorder 103 96.68 Very High Very High Very High
Affective Disorder 47 71.60 Quite High
Manic Depressive Disorder 31 70.04 Quite High
Disease 16 63.60 Quite High
Congenital Anomalies 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the identification of genes involved in the regulation of TST immobility represents a forward genetic approach to identifying genes that may play a role in human depression.
Regulation (regulation) of TST associated with depression
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012073 Disease Relevance 0.93 Pain Relevance 0.22
Although behavioral despair models only one aspect of human depression, it has both high face validity, as genes that are known to be involved in human depression affect mouse TST performance, and high predictive validity for antidepressant efficacy [8].
Regulation (affect) of TST in face associated with antidepressant and depression
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012073 Disease Relevance 0.93 Pain Relevance 0.22
In order to identify novel genes involved in the regulation of TST performance, we crossed an inbred strain exhibiting low immobility in the TST (RIIIS/J) with two high-immobility strains (C57BL/6J and NZB/BlNJ) to create two distinct F2 hybrid populations.
Regulation (regulation) of TST associated with sprains and strains
3) Confidence 0.38 Published 2010 Journal Mamm Genome Section Abstract Doc Link PMC2890984 Disease Relevance 0.35 Pain Relevance 0.05
Reverse genetic studies using knockout or knockdown mouse models have identified a number of genes, primarily genes involved in monoaminergic neurotransmission and the stress response axis, that affect TST immobility [8], [53].
Regulation (affect) of TST associated with stress, targeted disruption and monoamine
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012073 Disease Relevance 0.64 Pain Relevance 0.29
In vivo pharmacological manipulation of Gabra3 confirmed a regulatory role for this gene in mouse TST performance.
Regulation (role) of TST
5) Confidence 0.28 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.63 Pain Relevance 0.05
The higher dose of SB-205384 had no effect on TST immobility in either strain.
Neg (no) Regulation (effect) of TST associated with sprains and strains
6) Confidence 0.28 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.36 Pain Relevance 0.18
3 subunit regulates TST performance, B6 mice, which express Gabra3, would be expected to respond to the drug, while NZB mice, which lack Gabra3 expression, would not respond.
Regulation (regulates) of TST
7) Confidence 0.28 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.36 Pain Relevance 0.25
The anti-immobility effect of the extract (600 mg/kg, i.p.) assessed in the TST was not affected by pre-treatment with naloxone (1 mg/kg, i.p., a non-selective opioid receptor antagonist) or L-arginine (750 mg/kg, i.p., a nitric oxide precursor).
Neg (not) Regulation (affected) of TST associated with antagonist, narcan and opioid receptor
8) Confidence 0.23 Published 2002 Journal Life Sci. Section Abstract Doc Link 11885577 Disease Relevance 0.07 Pain Relevance 0.69
We exploited the heritability of these behavioral traits by using in silico haplotype-based association mapping to identify candidate genes for regulating TST behavior.
Regulation (regulating) of TST
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012073 Disease Relevance 0.78 Pain Relevance 0.08
Several groups have used quantitative trait locus (QTL) mapping to identify loci believed to regulate variability in TST performance (Lad et al. 2007; Liu et al. 2007; Tomida et al. 2009; Turri et al. 2001; Yoshikawa et al. 2002).
Regulation (regulate) of TST
10) Confidence 0.17 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.65 Pain Relevance 0.19
The effect of drug treatment on TST and OF behavior was determined by using an unpaired, unequal variance t test (JMP, SAS Software, Cary, NC).


Regulation (effect) of TST
11) Confidence 0.17 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.18 Pain Relevance 0
3 subunit in regulating TST performance.
Regulation (regulating) of TST
12) Confidence 0.17 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.14 Pain Relevance 0.25
Treatment with the non-specific GABAA agonist diazepam affected TST and OFT performance in both strains, indicating that NZB mice are capable of responding to GABAergic drugs acting at subunits other than ?
Regulation (affected) of TST associated with gabaergic, agonist and sprains and strains
13) Confidence 0.17 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.16 Pain Relevance 0.25
First, deletion or overexpression of genes linked to human depression affects immobility in the TST and FST (Cryan et al. 2005; Urani et al. 2005).
Regulation (affects) of TST associated with depression
14) Confidence 0.17 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.84 Pain Relevance 0.32
Garlic extract (25, 50 and 100 mg/kg, p.o.) administered to mice for 14 successive days decreased immobility periods significantly in a dose-dependent manner, as compared to control in both TST and FST, indicating significant antidepressant-like activity.
Regulation (control) of TST associated with antidepressant and eae
15) Confidence 0.12 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792615 Disease Relevance 0 Pain Relevance 0.59
Changes in general activity can affect animal behavior in FST and TST [79,80].
Regulation (affect) of TST associated with eae
16) Confidence 0.12 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.30 Pain Relevance 0.33

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