INT101516

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.75
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PPARD) nucleoplasm (PPARD) DNA binding (PPARD)
lipid metabolic process (PPARD) cell proliferation (PPARD) lipid binding (PPARD)
Anatomy Link Frequency
epithelial cell 1
keratinocytes 1
NUC-1 1
PPARD (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 10 98.32 Very High Very High Very High
cINOD 35 98.28 Very High Very High Very High
agonist 120 89.28 High High
Inflammation 147 85.60 High High
psoriasis 4 85.60 High High
antagonist 5 83.60 Quite High
cytokine 24 78.08 Quite High
Thalamus 1 54.44 Quite High
Calcitonin gene-related peptide 1 53.20 Quite High
Inflammatory response 14 42.32 Quite Low
Disease Link Frequency Relevance Heat
Keratosis 3 99.82 Very High Very High Very High
Apoptosis 63 99.60 Very High Very High Very High
Skin Cancer 6 99.28 Very High Very High Very High
Hepatocellular Cancer 8 98.84 Very High Very High Very High
INFLAMMATION 164 97.56 Very High Very High Very High
Cancer 35 94.60 High High
Malignant Neoplastic Disease 2 93.76 High High
Erythema 1 91.84 High High
Psoriasis 5 85.60 High High
Liver Cancer 7 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because peroxisome proliferator-activated receptor delta-mediated 14-3-3epsilon up-regulation was reported to play a crucial role in protecting against apoptosis, we determined whether NSAIDs suppress this transcriptional pathway.
Positive_regulation (up-regulation) of peroxisome proliferator-activated receptor delta associated with cinod and apoptosis
1) Confidence 0.49 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678619 Disease Relevance 0.67 Pain Relevance 0.67
, NUC-1, or FAAR) are activated by naturally occurring fatty acids and act as sensors
Positive_regulation (activated) of FAAR in NUC-1
2) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 0 Pain Relevance 0.04
Also transactivation of peroxisome proliferator response element was attenuated by ultraviolet B irradiation.
Positive_regulation (transactivation) of peroxisome proliferator response element
3) Confidence 0.38 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11886504 Disease Relevance 0.63 Pain Relevance 0.41
It has been reported that PPARalpha immunoreactivity is reduced in human keratinocytes of squamous cell carcinoma (SCC) and actinic keratosis (AK), while PPARdelta appears to be upregulated.
Spec (appears) Positive_regulation (upregulated) of PPARdelta in keratinocytes associated with skin cancer and keratosis
4) Confidence 0.34 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092840 Disease Relevance 1.82 Pain Relevance 0.17
Since the peroxisome proliferator-activated receptor was expressed at a very low level and was not stimulated by clofibrate in the AH-130 hepatoma cells, its involvement seems unlikely.
Neg (not) Positive_regulation (stimulated) of proliferator-activated receptor associated with hepatocellular cancer
5) Confidence 0.09 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 1.22 Pain Relevance 0.04
Peroxisome proliferator-activated receptor response element

(PPRE) is defined as a direct repeat of two core recognition

Positive_regulation (Peroxisome) of proliferator-activated receptor response element
6) Confidence 0.05 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.05 Pain Relevance 0.06
Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line.
Positive_regulation (upregulation) of PPARdelta in epithelial cell
7) Confidence 0.05 Published 2005 Journal Oncogene Section Title Doc Link 16091736 Disease Relevance 0.19 Pain Relevance 0.50
M for the induction of peroxisome proliferator response element (PPRE)-luciferase activity.
Positive_regulation (induction) of peroxisome proliferator response element
8) Confidence 0.04 Published 2008 Journal Journal of Medicinal Chemistry Section Abstract Doc Link PMC2651753 Disease Relevance 0.16 Pain Relevance 0.26
The remaining two significantly regulated genes (for orphan nuclear hormone receptor BD73 and pepsinogen C) were initially identified as downregulated by greater than fourfold.
Positive_regulation (orphan) of nuclear hormone receptor
9) Confidence 0.03 Published 2002 Journal Genome Biol Section Body Doc Link PMC115222 Disease Relevance 0 Pain Relevance 0.03

General Comments

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