INT101517

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2011
Negated 0
Speculated 7
Reported most in Body
Documents 168
Total Number 176
Disease Relevance 112.24
Pain Relevance 21.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
colon 3
chondrocytes 2
stroma 1
plasma 1
liver 1
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1892 100.00 Very High Very High Very High
antagonist 319 100.00 Very High Very High Very High
COX2 166 100.00 Very High Very High Very High
COX-2 inhibitor 134 100.00 Very High Very High Very High
Inflammatory stimuli 25 99.98 Very High Very High Very High
Osteoarthritis 1560 99.86 Very High Very High Very High
Inflammation 1778 99.60 Very High Very High Very High
cytokine 394 99.38 Very High Very High Very High
ischemia 76 99.34 Very High Very High Very High
fibrosis 53 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 894 100.00 Very High Very High Very High
Malignant Neoplastic Disease 274 100.00 Very High Very High Very High
Targeted Disruption 216 100.00 Very High Very High Very High
Repression 207 100.00 Very High Very High Very High
Apoptosis 2582 99.98 Very High Very High Very High
Colon Cancer 872 99.98 Very High Very High Very High
Osteoarthritis 1584 99.86 Very High Very High Very High
Prostate Cancer 145 99.86 Very High Very High Very High
Disease 1117 99.84 Very High Very High Very High
INFLAMMATION 2199 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effect of PPAR?
Negative_regulation (effect) of PPAR
1) Confidence 0.57 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.67 Pain Relevance 0.24
Although the authors provided no mechanism to explain these findings, they speculated that C allele carriers had reduced PPAR?
Negative_regulation (reduced) of PPAR
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.46 Pain Relevance 0
activation is deleterious during experimental myocardial ischemia [38]–[49], we hypothesized that diminished PPAR?
Spec (hypothesized) Negative_regulation (diminished) of PPAR associated with coronary artery disease and ischemia
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.73 Pain Relevance 0.09
and hydatiform moles, a downregulation of the PPAR?
Negative_regulation (downregulation) of PPAR
4) Confidence 0.56 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0.40 Pain Relevance 0.04
The inhibition of PPAR?
Negative_regulation (inhibition) of PPAR
5) Confidence 0.56 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0.52 Pain Relevance 0.04
Another mutation decreasing PPAR?
Negative_regulation (decreasing) of PPAR
6) Confidence 0.53 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.69 Pain Relevance 0.06
have shown that heterozygous loss of PPAR?
Negative_regulation (loss) of PPAR
7) Confidence 0.49 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 1.11 Pain Relevance 0.08
Compatible with these findings, heteroxygous loss of PPAR?
Negative_regulation (loss) of PPAR
8) Confidence 0.49 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 1.00 Pain Relevance 0
To complicate the issues even further is the fact that the inhibitory effect of PPAR?
Negative_regulation (effect) of PPAR
9) Confidence 0.49 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 1.35 Pain Relevance 0.14
the decrease of PPAR?
Negative_regulation (decrease) of PPAR
10) Confidence 0.43 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.94 Pain Relevance 0
The prevalence of survival over proliferation was confirmed by Bcl-2 or Bcl-XL increase in cancer versus mucosa, and by decreased PPAR?.
Negative_regulation (decreased) of PPAR associated with cancer
11) Confidence 0.43 Published 2007 Journal PPAR Research Section Abstract Doc Link PMC1852897 Disease Relevance 0.93 Pain Relevance 0.04
apoptosis, a specific antagonist for each PPAR studied was added
Negative_regulation (antagonist) of PPAR associated with antagonist and apoptosis
12) Confidence 0.43 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.62 Pain Relevance 0.18
In addition to suppressing VLDL production, PPAR?
Negative_regulation (suppressing) of PPAR
13) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.28 Pain Relevance 0.17
The current results suggest an alternate explanation for the previously described associations with the PPARA intronic SNP and provide evidence to support the authors' hypothesis that C allele carriers have reduced PPAR?
Negative_regulation (reduced) of PPAR
14) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.97 Pain Relevance 0.08
ligands are mostly thought to be based on “transrepression” by the negative interference of PPAR?
Negative_regulation (interference) of PPAR
15) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.43 Pain Relevance 0.11
are likely explained by interference of PPAR?
Negative_regulation (interference) of PPAR
16) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.63 Pain Relevance 0.26
Thus, the precise target genes underlying the suppressive effect of PPAR?
Negative_regulation (effect) of PPAR
17) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.27 Pain Relevance 0.16
To determine whether these MAPKs are involved in the IL-1-mediated downregulation of PPAR?
Spec (whether) Negative_regulation (downregulation) of PPAR
18) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.24 Pain Relevance 0.12
To assess the contribution of these pathways in the IL-1-mediated downregulation of PPAR?
Negative_regulation (downregulation) of PPAR
19) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.15 Pain Relevance 0.08
As shown in Figure 6b, treatment with IL-1 decreased PPAR?
Negative_regulation (decreased) of PPAR
20) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.20 Pain Relevance 0.06

General Comments

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