INT101537

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 19
Total Number 28
Disease Relevance 1.88
Pain Relevance 20.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Vta1) transport (Vta1) cytoplasm (Vta1)
Anatomy Link Frequency
neurons 4
dopaminergic neurons 3
substantia nigra 1
nucleus accumbens 1
DA neurons 1
Vta1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1407 100.00 Very High Very High Very High
Ventral tegmentum 1036 100.00 Very High Very High Very High
Opioid 100 100.00 Very High Very High Very High
Substantia nigra 24 100.00 Very High Very High Very High
antagonist 443 99.84 Very High Very High Very High
gABA 56 99.84 Very High Very High Very High
nMDA receptor antagonist 35 99.76 Very High Very High Very High
GABAergic 9 99.76 Very High Very High Very High
Cannabinoid receptor 11 99.50 Very High Very High Very High
Morphine 60 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 16 98.32 Very High Very High Very High
Targeted Disruption 57 92.32 High High
Nicotine Addiction 64 83.68 Quite High
Depression 12 76.80 Quite High
Apoptosis 20 74.32 Quite High
Drug Dependence 45 74.00 Quite High
Cannabis Dependence 18 70.24 Quite High
Hypertrophy 6 56.48 Quite High
Hyperphagia 18 51.92 Quite High
Brain Tumor 2 49.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-receptor-mediated control of GABA transmission following chronic morphine treatment is a critical mechanism that determines the expression of opioid reward in the VTA.
Spec (determines) Gene_expression (expression) of VTA associated with ventral tegmentum, gaba, opioid and morphine
1) Confidence 0.50 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20962224 Disease Relevance 0 Pain Relevance 1.53
RESULTS: Sulpiride produced an extinction of intra-VTA, but not intra-NAC, morphine self-administration.
Neg (not) Gene_expression (produced) of intra-VTA
2) Confidence 0.41 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 11889500 Disease Relevance 0 Pain Relevance 0
The activation of the mesolimbic dopamine system by ghrelin may be due to the reported ability of the GHS-R1A to dimerize with the dopamine D1 receptor, both receptors expressed on dopamine neurons in the VTA, and thereby amplifies the dopamine signalling (Jiang, Betancourt & Smith 2006).
Gene_expression (expressed) of VTA in dopamine neurons associated with ventral tegmentum and dopamine
3) Confidence 0.40 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.78
Effects of intra-VTA administration of a NMDA receptor antagonist on ghrelin-induced locomotor stimulation and increased accumbal dopamine release in mice
Gene_expression (administration) of VTA associated with ventral tegmentum, dopamine and nmda receptor antagonist
4) Confidence 0.40 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.87
Specifically, the ghrelin-induced locomotor stimulation (P < 0.01) was attenuated by VTA administration of AP5 (P < 0.001) in mice (F(3,27) = 8.06, P < 0.001: n = 7-8).
Gene_expression (administration) of VTA associated with ventral tegmentum and antagonist
5) Confidence 0.40 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.90
Although, GABAA receptors in the VTA does not mediate the increase in accumbal dopamine observed after food consumption induced by ghrelin (Kawahara et al. 2009).
Gene_expression (receptors) of VTA associated with ventral tegmentum and dopamine
6) Confidence 0.40 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0.05 Pain Relevance 0.74
Intra-VTA administration of the NMDA receptor antagonist, AP5, abolished the ghrelin-induced locomotor stimulation and accumbal dopamine release (Figs 3a,b), at a dose that had no effect per se (Table 1).
Gene_expression (administration) of VTA associated with ventral tegmentum, dopamine, nmda receptor antagonist and antagonist
7) Confidence 0.40 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.89
In the present experiments therefore we sought to determine whether VTA administration of a GHS-R1A antagonist suppresses the locomotor stimulatory and accumbal dopamine releasing effects of peripheral ghrelin.
Gene_expression (administration) of VTA associated with ventral tegmentum, dopamine and antagonist
8) Confidence 0.40 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.88
Finally, ghrelin-induced locomotor stimulation as well as accumbal dopamine release were suppressed by VTA administration of an NMDA receptor antagonist (AP5).
Gene_expression (administration) of VTA associated with ventral tegmentum, nmda receptor antagonist, dopamine and antagonist
9) Confidence 0.40 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 1.04
The ghrelin-induced locomotor stimulation (P < 0.01) was not affected by VTA administration of the orexin A receptor antagonist SB334867 (P > 0.05) in mice (F(3,24) = 8.44, P = 0.005: n = 6–8) (Fig. 2a).
Gene_expression (administration) of VTA associated with ventral tegmentum and antagonist
10) Confidence 0.40 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.81
Effects of intra-VTA administration of an orexin A receptor antagonist or peripheral injection of an opioid receptor antagonist on ghrelin-induced locomotor stimulation in mice
Gene_expression (administration) of VTA associated with ventral tegmentum, antagonist and opioid receptor
11) Confidence 0.40 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.70
However, whether or not reciprocal connections between glutamatergic or GABAergic nuclei and DA VTA neurons were potentiated with this protocol cannot be ruled out.
Gene_expression (neurons) of VTA in neurons associated with ventral tegmentum, dopamine and gabaergic
12) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013137 Disease Relevance 0 Pain Relevance 0.91
To validate this approach we injected cocaine intraperitoneally (i.p.) whilst recording from VTA neurons in vivo and observed an inhibition in the in vivo firing rate of VTA neurons in WT mice but not in the DATKI (Figure 1A, B).
Gene_expression (neurons) of VTA in neurons associated with ventral tegmentum and cocaine
13) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013137 Disease Relevance 0 Pain Relevance 0.99
Following electrophysiological recordings, Chicago Sky blue dye was iontophoretically injected into the recording site (Stoelting, Wood Dale, IL) for confirmation that the recordings were made within the VTA.
Gene_expression (made) of VTA associated with ventral tegmentum
14) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013137 Disease Relevance 0 Pain Relevance 0.43
It is important to point out that besides DA neurons, GABAergic neurons in VTA which provide important regulation to DA neuron also express NMDAR1.
Gene_expression (express) of VTA in GABAergic neurons associated with ventral tegmentum and gabaergic
15) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0.08 Pain Relevance 0.88
In the VTA, the action of these drugs is preferentially on the ?
Gene_expression (is) of VTA associated with ventral tegmentum
16) Confidence 0.10 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1635740 Disease Relevance 0 Pain Relevance 0.82
In the VTA, these receptors are expressed on GABA neurons and on terminals of glutamatergic synapses on dopamine neurons [12].
Gene_expression (expressed) of VTA in neurons associated with ventral tegmentum, dopamine and gaba
17) Confidence 0.09 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1635740 Disease Relevance 0.05 Pain Relevance 1.27
Indeed, it has been reported that cocaine activated ERK in the VTA following repeated but not single injections [17,18] whereas D-amph activated ERK in the VTA following single but not repeated injections [21].
Gene_expression (following) of VTA associated with ventral tegmentum and cocaine
18) Confidence 0.09 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.66
The area of TH+ neurons in the SNc and VTA was estimated using the nucleator probe.
Gene_expression (neurons) of VTA in neurons associated with ventral tegmentum
19) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.08
Stereological cell counts of TH positive profiles in the substantia nigra and VTA were significantly elevated already at postnatal day two (data not presented), indicating an early expression of anatomical changes mediated by Pten ablation.
Gene_expression (profiles) of VTA in substantia nigra associated with ventral tegmentum and substantia nigra
20) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.22 Pain Relevance 0.43

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