INT101542

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.34
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (RRAD) plasma membrane (RRAD) GTPase activity (RRAD)
Anatomy Link Frequency
masseter 2
RRAD (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain threshold 2 99.12 Very High Very High Very High
depression 4 96.24 Very High Very High Very High
fibrosis 1 84.32 Quite High
Sciatic nerve 3 58.72 Quite High
Inflammation 1 57.36 Quite High
Pain 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 145 100.00 Very High Very High Very High
Disease 4 99.92 Very High Very High Very High
Pain 3 99.12 Very High Very High Very High
Ketoacidosis 1 98.52 Very High Very High Very High
Obesity 6 96.84 Very High Very High Very High
Ketosis 1 96.32 Very High Very High Very High
Depression 4 96.24 Very High Very High Very High
Neuropathic Pain 1 93.80 High High
Renal Disease 1 93.20 High High
Ocular Toxicity (including Many Sub-types) 1 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The upregulation of Rrad provides a potential mechanism for previous reports that acute RE reduces insulin-stimulated glucose uptake [40-42].
Positive_regulation (upregulation) of Rrad
1) Confidence 0.44 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.59 Pain Relevance 0.03
The duration of masseter muscle inhibition, induced by MED and/or RAD stimulation, was inversely related to the level of EMG activity, while latency was not related to it.
Positive_regulation (stimulation) of RAD in masseter
2) Confidence 0.41 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 11889506 Disease Relevance 0.39 Pain Relevance 0.15
EMG voluntary activity was recorded from both masseter muscles by means of coaxial needle electrodes before and after the electrical stimulation of MED and/or RAD at intensities below pain threshold.
Positive_regulation (stimulation) of RAD in masseter associated with pain threshold
3) Confidence 0.33 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 11889506 Disease Relevance 0.34 Pain Relevance 0.15
Two clusters included genes upregulated at 6 hours after RE (Figure 5), one centered on Nr4a3 (Figure 5a) and the other on Rrad (Figure 5b).
Positive_regulation (upregulated) of Rrad
4) Confidence 0.29 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
Rrad was cloned because it was upregulated in patients with type II diabetes [38].
Positive_regulation (upregulated) of Rrad associated with diabetes mellitus
5) Confidence 0.29 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.57 Pain Relevance 0.03
Similarly, although the diabetes is severe and insulin requiring in both FCPD and type 1 diabetes (T1D), FCPD patients rarely develop ketoacidosis, in contrast to the T1D patients, who are ketosis prone [9,10].
Positive_regulation (requiring) of diabetes associated with ketosis, ketoacidosis and diabetes mellitus
6) Confidence 0.00 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 3.46 Pain Relevance 0.07

General Comments

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