INT101556

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2008
Negated 3
Speculated 5
Reported most in Abstract
Documents 5
Total Number 10
Disease Relevance 2.81
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nt5e) cytoplasm (Nt5e)
Anatomy Link Frequency
blood 2
hippocampus 2
spinal cord 1
platelets 1
Nt5e (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 9 100.00 Very High Very High Very High
Nortriptyline 25 99.98 Very High Very High Very High
fluoxetine 25 99.82 Very High Very High Very High
antidepressant 8 99.78 Very High Very High Very High
Spinal cord 8 99.40 Very High Very High Very High
depression 8 98.72 Very High Very High Very High
adenocard 7 98.24 Very High Very High Very High
cerebral cortex 6 97.04 Very High Very High Very High
Central nervous system 4 95.48 Very High Very High Very High
sSRI 7 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 16 100.00 Very High Very High Very High
Depression 8 98.72 Very High Very High Very High
Pain 2 93.44 High High
Disorders Of Creatine Metabolism 2 93.04 High High
Cv General 3 Under Development 2 88.64 High High
Hyperalgesia 2 88.12 High High
Inborn Error Of Metabolism 2 85.36 High High
Hemorrhage 3 85.00 Quite High
Homocystinuria 2 84.12 Quite High
Disease 1 47.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluoxetine and nortriptyline affect NTPDase and 5'-nucleotidase activities in rat blood serum.
Regulation (affect) of nucleotidase in blood associated with nortriptyline and fluoxetine
1) Confidence 0.40 Published 2007 Journal Life Sci. Section Title Doc Link 17889906 Disease Relevance 0.27 Pain Relevance 0.74
In addition, there were no significant changes in NTPDase and ecto-5'-nucleotidase activities when fluoxetine and nortriptyline (100, 250, and 500 microM) were tested in vitro.
Neg (no) Regulation (changes) of nucleotidase associated with nortriptyline and fluoxetine
2) Confidence 0.40 Published 2007 Journal Life Sci. Section Abstract Doc Link 17889906 Disease Relevance 0.12 Pain Relevance 0.96
No effect on ADPase, ATPase or on 5'-nucleotidase activity was observed in females with chronic stress, or after acute stress neither in males or females.
Neg (No) Regulation (effect) of nucleotidase associated with stress
3) Confidence 0.30 Published 2002 Journal Physiol. Behav. Section Abstract Doc Link 11890946 Disease Relevance 0.78 Pain Relevance 0.33
Thus, the current study investigated the effect of homocysteine administration on NTPDase and 5'-nucleotidase activities, in the synaptosomal fraction of rat hippocampus, and on nucleotidase activities in rat serum.
Spec (investigated) Regulation (effect) of nucleotidase in hippocampus associated with hippocampus
4) Confidence 0.29 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15202768 Disease Relevance 0.26 Pain Relevance 0.30
Thus, the current study investigated the effect of homocysteine administration on NTPDase and 5'-nucleotidase activities, in the synaptosomal fraction of rat hippocampus, and on nucleotidase activities in rat serum.
Spec (investigated) Regulation (effect) of nucleotidase in hippocampus associated with hippocampus
5) Confidence 0.29 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15202768 Disease Relevance 0.26 Pain Relevance 0.29
In contrast, fluoxetine did not alter NTPDase and ecto-5'-nucleotidase activities.
Neg (not) Regulation (alter) of nucleotidase associated with fluoxetine
6) Confidence 0.29 Published 2007 Journal Life Sci. Section Abstract Doc Link 17889906 Disease Relevance 0.21 Pain Relevance 0.94
In the present study, we investigated the effect of chronic and acute stress on ATPase-ADPase and 5'-nucleotidase activities in spinal cord of male and female rats.
Spec (investigated) Regulation (effect) of nucleotidase in spinal cord associated with stress and spinal cord
7) Confidence 0.22 Published 2002 Journal Physiol. Behav. Section Abstract Doc Link 11890946 Disease Relevance 0.67 Pain Relevance 0.35
The aim of this work was to investigate the in vitro effect of guanidinoacetate in NTPDase, 5'-nucleotidase and acetylcholinesterase activities in the synaptosomes, platelets and blood of rats.
Spec (investigate) Regulation (effect) of nucleotidase in blood
8) Confidence 0.13 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18256932 Disease Relevance 0.09 Pain Relevance 0
The findings showed that these antidepressant drugs can affect the ecto-nucleotidase pathway, suggesting that the extracellular adenosine levels could be modulated by these drugs.
Regulation (affect) of ecto-nucleotidase associated with adenocard and antidepressant
9) Confidence 0.07 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18280468 Disease Relevance 0.06 Pain Relevance 1.28
The aim of this work was to investigate the in vitro effect of guanidinoacetate in NTPDase, 5'-nucleotidase and acetylcholinesterase activities in the synaptosomes, platelets and blood of rats.
Spec (investigate) Regulation (effect) of nucleotidase in platelets
10) Confidence 0.04 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18256932 Disease Relevance 0.09 Pain Relevance 0

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