INT101567

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 10.11
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
facial nerve 1
nucleus 1
Ctnnb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 3 99.68 Very High Very High Very High
cocaine 105 99.44 Very High Very High Very High
cINOD 21 98.52 Very High Very High Very High
Inflammation 16 97.44 Very High Very High Very High
antagonist 5 96.24 Very High Very High Very High
Peripheral nervous system 1 91.52 High High
Nucleus accumbens 35 90.12 High High
aspirin 8 87.00 High High
COX2 1 25.00 Low Low
tetrodotoxin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 70 99.96 Very High Very High Very High
Aids-related Complex 11 99.96 Very High Very High Very High
Cancer 25 99.84 Very High Very High Very High
INFLAMMATION 27 97.44 Very High Very High Very High
Rheumatoid Arthritis 15 96.56 Very High Very High Very High
Colon Cancer 5 89.16 High High
Colitis 5 82.80 Quite High
Malignant Neoplastic Disease 10 75.00 Quite High
Body Weight 1 54.96 Quite High
Carcinoma 1 41.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When we compared the PCNA-LI in the ACF showing normal beta-catenin expression pattern with that in the ACF showing abnormal beta-catenin expression pattern (overexpression in cytoplasm), there was no significant difference of the PCNA-LI in these two different types of ACF.
Gene_expression (expression) of beta-catenin associated with aberrant crypt foci
1) Confidence 0.64 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.84 Pain Relevance 0.34
Furthermore, we examined the expression and the localization of beta-catenin protein, and the proliferating cell nuclear antigen (PCNA)-labeling index (LI) in ACF and cancer.
Spec (examined) Gene_expression (expression) of beta-catenin associated with aberrant crypt foci and cancer
2) Confidence 0.64 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.75 Pain Relevance 0.41
When we compared the PCNA-LI in the ACF showing normal beta-catenin expression pattern with that in the ACF showing abnormal beta-catenin expression pattern (overexpression in cytoplasm), there was no significant difference of the PCNA-LI in these two different types of ACF.
Gene_expression (expression) of beta-catenin associated with aberrant crypt foci
3) Confidence 0.64 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.88 Pain Relevance 0.35
In all of the cancer cells, beta-catenin was overexpressed in the nucleus.
Gene_expression (overexpressed) of beta-catenin in nucleus associated with cancer
4) Confidence 0.64 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.91 Pain Relevance 0.36
In about 9% of the ACF, beta-catenin was overexpressed not only on the cell membrane but also in the cytoplasm.
Gene_expression (overexpressed) of beta-catenin associated with aberrant crypt foci
5) Confidence 0.64 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.94 Pain Relevance 0.37
Nitric oxide synthase 2 (NOS-2) activity and beta-catenin expression were suppressed in animals given NO-NSAID.
Gene_expression (expression) of beta-catenin associated with cinod
6) Confidence 0.38 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16818512 Disease Relevance 0.53 Pain Relevance 0.46
We investigated in the rat the effect of axotomy on the different subunits of excitatory glutamatergic AMPA (GLuR1-4), NMDA (NR1, NR2A-D) receptors, post-synaptic density 95, vesicular glutamate transporter 2, beta catenin and cadherin. mRNA levels and/or protein production were analyzed 1, 3, 8, 30 and 60 days after facial nerve axotomy by in situ hybridization and immunohistofluorescence. mRNAs coding for the GLuR2-4, NR1, NR2A, B, D subunits of glutamatergic receptors and for post-synaptic density 95, were less abundant after axotomy.
Gene_expression (production) of beta catenin in facial nerve associated with glutamate
7) Confidence 0.22 Published 2005 Journal Neuroscience Section Abstract Doc Link 16182453 Disease Relevance 0 Pain Relevance 0.13
Arc, Beta-catenin, Cap2, Crip2, Dnm2, Egr2, Fos, Fut8, GFAP, Gpr88, Htr1d, and Nr4a1 were all confirmed by qPCR to be differentially expressed.
Gene_expression (expressed) of Beta-catenin associated with aids-related complex
8) Confidence 0.13 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.26 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox