INT101568

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.24
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Pcna) nucleus (Pcna) intracellular (Pcna)
DNA binding (Pcna) transcription factor binding (Pcna) cytoplasm (Pcna)
Pcna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 3 97.96 Very High Very High Very High
antagonist 1 96.76 Very High Very High Very High
cINOD 3 94.20 High High
fibrosis 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 96 99.02 Very High Very High Very High
Aberrant Crypt Foci 14 98.76 Very High Very High Very High
Cancer 34 98.44 Very High Very High Very High
INFLAMMATION 5 97.96 Very High Very High Very High
Rheumatoid Arthritis 3 97.08 Very High Very High Very High
Polycystic Kidney Disease 108 95.64 Very High Very High Very High
Disease 78 94.56 High High
Targeted Disruption 12 93.36 High High
Disease Progression 12 91.32 High High
Cyst 63 90.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we examined the expression and the localization of beta-catenin protein, and the proliferating cell nuclear antigen (PCNA)-labeling index (LI) in ACF and cancer.
Spec (examined) Negative_regulation (examined) of proliferating cell nuclear antigen associated with aberrant crypt foci and cancer
1) Confidence 0.41 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.84 Pain Relevance 0.42
One of these pathways involves key arbiters of cell cycle progression and apoptosis, the cyclins, their associated kinases, and the cyclin kinase inhibitors, of which group p21 is a member.
Negative_regulation (inhibitors) of cyclin associated with apoptosis
2) Confidence 0.01 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.48 Pain Relevance 0
Very recent data has supported the role of cyclin kinase inhibition as possible treatment of PKD, using the specific inhibitor roscovitine[10].
Spec (possible) Negative_regulation (inhibition) of cyclin
3) Confidence 0.01 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.75 Pain Relevance 0
We have shown that p21, a cyclin kinase inhibitor which mediates cell cycle progression as well as apoptosis, is decreased in a rat model as well as in human ADPKD, and that roscovitine, which has been shown to have a salutary effect in an animal model of this disease, increases levels of p21.
Negative_regulation (inhibitor) of cyclin associated with polycystic kidney disease, disease and apoptosis
4) Confidence 0.01 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.17 Pain Relevance 0

General Comments

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