INT101569

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 6.35
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (A1cf) mRNA processing (A1cf) endoplasmic reticulum (A1cf)
nucleus (A1cf) intracellular (A1cf) cytoplasm (A1cf)
A1cf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 14 84.24 Quite High
antagonist 3 79.96 Quite High
cINOD 9 77.40 Quite High
gABA 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 71 100.00 Very High Very High Very High
Cancer 26 94.88 High High
Colon Cancer 21 93.84 High High
Rheumatoid Arthritis 9 89.80 High High
INFLAMMATION 20 81.16 Quite High
Malignant Neoplastic Disease 9 75.00 Quite High
Colitis 3 66.52 Quite High
Apoptosis 1 46.68 Quite Low
Colorectal Cancer 1 25.48 Quite Low
Familial Adenomatous Polyposis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When we compared the PCNA-LI in the ACF showing normal beta-catenin expression pattern with that in the ACF showing abnormal beta-catenin expression pattern (overexpression in cytoplasm), there was no significant difference of the PCNA-LI in these two different types of ACF.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ACF associated with aberrant crypt foci
1) Confidence 0.49 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.83 Pain Relevance 0.34
In about 9% of the ACF, beta-catenin was overexpressed not only on the cell membrane but also in the cytoplasm.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ACF associated with aberrant crypt foci
2) Confidence 0.49 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.95 Pain Relevance 0.37
When we compared the PCNA-LI in the ACF showing normal beta-catenin expression pattern with that in the ACF showing abnormal beta-catenin expression pattern (overexpression in cytoplasm), there was no significant difference of the PCNA-LI in these two different types of ACF.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ACF associated with aberrant crypt foci
3) Confidence 0.43 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.86 Pain Relevance 0.34
The administration of 2.5 g/kg, 5 g/kg and 10 g/kg of GBR (weight of GBR (g)/weight of rat (kg)) significantly reduced the total number of ACF, AC, and multicrypt of ACF, and the expression of ?
Positive_regulation (multicrypt) of Gene_expression (expression) of ACF associated with aberrant crypt foci
4) Confidence 0.10 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.71 Pain Relevance 0

General Comments

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