INT101570

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 5.70
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
nucleus 2
Ctnnb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 9 80.96 Quite High
antagonist 3 79.76 Quite High
cINOD 9 77.20 Quite High
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 42 99.96 Very High Very High Very High
Cancer 12 99.84 Very High Very High Very High
Rheumatoid Arthritis 9 89.60 High High
INFLAMMATION 15 80.96 Quite High
Malignant Neoplastic Disease 6 75.00 Quite High
Colitis 3 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all of the cancer cells, beta-catenin was overexpressed in the nucleus.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of beta-catenin in nucleus associated with cancer
1) Confidence 0.58 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.91 Pain Relevance 0.36
In about 9% of the ACF, beta-catenin was overexpressed not only on the cell membrane but also in the cytoplasm.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of beta-catenin associated with aberrant crypt foci
2) Confidence 0.58 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.94 Pain Relevance 0.37
When we compared the PCNA-LI in the ACF showing normal beta-catenin expression pattern with that in the ACF showing abnormal beta-catenin expression pattern (overexpression in cytoplasm), there was no significant difference of the PCNA-LI in these two different types of ACF.
Positive_regulation (overexpression) of Gene_expression (expression) of beta-catenin associated with aberrant crypt foci
3) Confidence 0.39 Published 2002 Journal Int. J. Mol. Med. Section Abstract Doc Link 11891526 Disease Relevance 1.84 Pain Relevance 0.34

General Comments

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