INT101572

Context Info Confidence 0.53 First Reported 2002 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 24 Total Number 26 Disease Relevance 13.87 Pain Relevance 2.21

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA) nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)

Anatomy Link Frequency liver 4 pituitary 2 PCNA (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 18 100.00 aspirin 68 99.68 Paracetamol 7 99.10 Inflammation 38 97.96 antagonist 12 96.76 cINOD 16 94.20 methotrexate 18 89.72 COX-2 inhibitor 15 85.36 headache 1 82.88 Pain 6 79.04

Disease Link Frequency Relevance Heat Cancer 298 100.00 Carcinoma 59 100.00 Pituitary Cancer 2 100.00 Hyperplasia 51 99.44 Aberrant Crypt Foci 14 99.00 Pituitary Apoplexy 4 98.28 INFLAMMATION 52 97.96 Rheumatoid Arthritis 3 97.08 Apoptosis 437 96.72 Toxicity 13 96.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PCNA expression was downregulated by NS-398 in a dose-independent manner.

Negative_regulation (downregulated) of Gene_expression (expression) of PCNA

1) Confidence 0.53 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12115513 Disease Relevance 0.57 Pain Relevance 0.27

Fan induced p27 expression and inhibited cyclin D and proliferating cell nuclear antigen (PCNA) expression in PC3 cells.

Negative_regulation (inhibited) of Gene_expression (expression) of proliferating cell nuclear antigen

2) Confidence 0.41 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20208355 Disease Relevance 1.25 Pain Relevance 0.08

Immunohistochemical analysis was used to define the different hormone types of the tumors and the expression of various immunologic targets, including the pituitary tumor transforming gene, basic fibroblast growth factor-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and proliferating cell nuclear antigen.

Negative_regulation (define) of Gene_expression (expression) of proliferating cell nuclear antigen in pituitary associated with cancer, pituitary cancer and metalloproteinase

3) Confidence 0.41 Published 2009 Journal J Clin Neurosci Section Abstract Doc Link 19046883 Disease Relevance 1.14 Pain Relevance 0.18

Indomethacin also down-regulated the expression of Bfl-1, WISP-1 and PCNA protein (40.01 +/- 1.61 vs 43.76 +/- 1.63, 22.50 +/- 1.17 vs 30.30 +/- 1.55, 17.69 +/- 1.18 vs 20.80 +/- 1.08).

Negative_regulation (down-regulated) of Gene_expression (expression) of PCNA protein

4) Confidence 0.39 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 17054584 Disease Relevance 0.07 Pain Relevance 0

RESULTS: Indomethacin down-regulated the expression of Bfl-1, WISP-1 and PCNA mRNA in vitro (9.53 +/- 0.15 vs 27.87 +/- 0.12, 7.37 +/- 0.58 vs 20.17 +/- 0.58, 5.17 +/- 0.06 vs 0.87 +/- 0.06).

Negative_regulation (down-regulated) of Gene_expression (expression) of PCNA mRNA

5) Confidence 0.39 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 17054584 Disease Relevance 0.07 Pain Relevance 0

Fan induced p27 expression and inhibited cyclin D and proliferating cell nuclear antigen (PCNA) expression in PC3 cells.

Negative_regulation (inhibited) of Gene_expression (expression) of PCNA

6) Confidence 0.29 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20208355 Disease Relevance 1.25 Pain Relevance 0.08

Immunohistochemistry revealed little or no staining for COX-2, increased expression of cleaved caspase-3, and decreased expression of PCNA and ?

Negative_regulation (decreased) of Gene_expression (expression) of PCNA

7) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.61 Pain Relevance 0

This could partly explain why there was significant reduction of PCNA expression in group C.

Negative_regulation (reduction) of Gene_expression (expression) of PCNA

8) Confidence 0.12 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.74 Pain Relevance 0.22

PCNA expression was significantly reduced in the aspirin and PEITC group.

Negative_regulation (reduced) of Gene_expression (expression) of PCNA associated with aspirin

9) Confidence 0.12 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1899177 Disease Relevance 0.62 Pain Relevance 0.31

At the same time, expression of VEGF and PCNA was markedly decreased in tumor tissues in the control group (Fig. 7).

Negative_regulation (decreased) of Gene_expression (expression) of PCNA associated with cancer

10) Confidence 0.10 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 0.76 Pain Relevance 0.04

MMP-9, VEGF and PCNA expression in residual hepatic VX2 carcinoma tissues

Negative_regulation (tissues) of Gene_expression (expression) of PCNA associated with carcinoma

11) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 0.51 Pain Relevance 0

Also, a ten-fold lower dose of EPO (500 IU/kg bw) led to decreased PCNA expression and a diminished DNA synthesis at the timepoint of maximal DNA-synthesis in comparison to animals without EPO treatment.

Negative_regulation (decreased) of Gene_expression (expression) of PCNA

12) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.32 Pain Relevance 0

Daily administration of high dose EPO (5000 IU/kg bw) in hepatectomized rats reduces the expression of PCNA and results in a significantly diminished restoration of liver mass.

Negative_regulation (reduces) of Gene_expression (expression) of PCNA in liver

13) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.38 Pain Relevance 0

Gallic acid treatment significantly attenuated some alterations (i.e. increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, 5'-nucleotidase, bilirubin, alpha-fetoprotein, carcinoembryonic antigen) and decreased the levels of argyophillic nucleolar organizing regions (AgNORs) and proliferating cell nuclear antigen (PCNA) [90].

Negative_regulation (decreased) of Gene_expression (levels) of PCNA

14) Confidence 0.07 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.06 Pain Relevance 0

showed that the HNE effects depend on the inhibition of the cyclin expression,

Negative_regulation (inhibition) of Gene_expression (expression) of cyclin

15) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.14 Pain Relevance 0

The hypophosphorylation of pRb proteins may depend on the inhibition of cyclin expression, however, this effect may also be

Negative_regulation (inhibition) of Gene_expression (expression) of cyclin

16) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.08 Pain Relevance 0

At day 3, PCNA expression was decreased to around 20% of the normal level and was still 50% of control level at day 7.

Negative_regulation (decreased) of Gene_expression (expression) of PCNA

17) Confidence 0.06 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.20 Pain Relevance 0.04

Unexpectedly, concurrent exposure to both estrogen and to sFasL led to a decrease in the expression of both PCNA and p21/waf1.

Negative_regulation (decrease) of Gene_expression (expression) of PCNA

18) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.47 Pain Relevance 0

Administration of EPO significantly reduced the expression of PCNA at 24 h followed by a significant decrease in restitution of liver mass at day 5 after partial hepatectomy.

Spec (partial) Negative_regulation (reduced) of Gene_expression (expression) of PCNA in liver

19) Confidence 0.05 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2592699 Disease Relevance 0.53 Pain Relevance 0.04

However, concurrent exposure to both estrogen and FasL did lead to a significant decrease in PCNA expression (Figure 9).

Negative_regulation (decrease) of Gene_expression (expression) of PCNA

20) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.55 Pain Relevance 0

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