INT101572
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
PCNA expression was downregulated by NS-398 in a dose-independent manner. | |||||||||||||||
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Fan induced p27 expression and inhibited cyclin D and proliferating cell nuclear antigen (PCNA) expression in PC3 cells. | |||||||||||||||
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Immunohistochemical analysis was used to define the different hormone types of the tumors and the expression of various immunologic targets, including the pituitary tumor transforming gene, basic fibroblast growth factor-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and proliferating cell nuclear antigen. | |||||||||||||||
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Indomethacin also down-regulated the expression of Bfl-1, WISP-1 and PCNA protein (40.01 +/- 1.61 vs 43.76 +/- 1.63, 22.50 +/- 1.17 vs 30.30 +/- 1.55, 17.69 +/- 1.18 vs 20.80 +/- 1.08). | |||||||||||||||
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RESULTS: Indomethacin down-regulated the expression of Bfl-1, WISP-1 and PCNA mRNA in vitro (9.53 +/- 0.15 vs 27.87 +/- 0.12, 7.37 +/- 0.58 vs 20.17 +/- 0.58, 5.17 +/- 0.06 vs 0.87 +/- 0.06). | |||||||||||||||
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Fan induced p27 expression and inhibited cyclin D and proliferating cell nuclear antigen (PCNA) expression in PC3 cells. | |||||||||||||||
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Immunohistochemistry revealed little or no staining for COX-2, increased expression of cleaved caspase-3, and decreased expression of PCNA and ? | |||||||||||||||
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This could partly explain why there was significant reduction of PCNA expression in group C. | |||||||||||||||
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PCNA expression was significantly reduced in the aspirin and PEITC group.
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At the same time, expression of VEGF and PCNA was markedly decreased in tumor tissues in the control group (Fig. 7). | |||||||||||||||
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MMP-9, VEGF and PCNA expression in residual hepatic VX2 carcinoma tissues | |||||||||||||||
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Also, a ten-fold lower dose of EPO (500 IU/kg bw) led to decreased PCNA expression and a diminished DNA synthesis at the timepoint of maximal DNA-synthesis in comparison to animals without EPO treatment. | |||||||||||||||
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Daily administration of high dose EPO (5000 IU/kg bw) in hepatectomized rats reduces the expression of PCNA and results in a significantly diminished restoration of liver mass. | |||||||||||||||
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Gallic acid treatment significantly attenuated some alterations (i.e. increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, 5'-nucleotidase, bilirubin, alpha-fetoprotein, carcinoembryonic antigen) and decreased the levels of argyophillic nucleolar organizing regions (AgNORs) and proliferating cell nuclear antigen (PCNA) [90]. | |||||||||||||||
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showed that the HNE effects depend on the inhibition of the cyclin expression, | |||||||||||||||
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The hypophosphorylation of pRb proteins may depend on the inhibition of cyclin expression, however, this effect may also be | |||||||||||||||
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At day 3, PCNA expression was decreased to around 20% of the normal level and was still 50% of control level at day 7. | |||||||||||||||
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Unexpectedly, concurrent exposure to both estrogen and to sFasL led to a decrease in the expression of both PCNA and p21/waf1. | |||||||||||||||
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Administration of EPO significantly reduced the expression of PCNA at 24 h followed by a significant decrease in restitution of liver mass at day 5 after partial hepatectomy. | |||||||||||||||
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However, concurrent exposure to both estrogen and FasL did lead to a significant decrease in PCNA expression (Figure 9). | |||||||||||||||
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General Comments
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