INT101577

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
peripheral nerve 1
NK cells 1
T cells 1
Klrb1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 7 98.24 Very High Very High Very High
Inflammation 3 77.52 Quite High
Demyelination 1 74.64 Quite High
Peripheral nervous system 1 72.96 Quite High
cytokine 2 25.00 Low Low
Pain 1 9.68 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 7 98.24 Very High Very High Very High
Immunization 1 97.08 Very High Very High Very High
Syndrome 1 94.52 High High
Autoimmune Disease 2 90.12 High High
Severe Combined Immunodeficiency 10 86.68 High High
INFLAMMATION 5 77.52 Quite High
Demyelinating Disease 1 74.64 Quite High
Lymphatic System Cancer 1 56.88 Quite High
Cancer 63 51.04 Quite High
Leukemia 1 44.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate that anti-NKR-P1A monoclonal antibody (mAb) treatment in vivo did not affect the initiation and development of clinical EAN in Lewis rats induced by immunization with peripheral nerve myelin P0 protein peptide 180-199 and Freund's complete adjuvant, as well as the proportion of NKR-P1A+ cells (including NK cells and NKT cells) in the spleen.
Neg (not) Regulation (affect) of NKR-P1A in peripheral nerve associated with immunization and neuritis
1) Confidence 0.44 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11891797 Disease Relevance 0.89 Pain Relevance 0.57
Cell numbers of CD3+CD161- T cells were not affected by the treatment.
Neg (not) Regulation (affected) of CD161 in T cells
2) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956665 Disease Relevance 0 Pain Relevance 0
For the depletion of NK cells, some rats received in addition to CsA intraperitoneal injections of the monoclonal antibody (mAb) anti-NKR-P1A (clone 10/78, mouse IgG1, BD Biosciences, Heidelberg, Germany) or the respective isotype control (clone PPV-06, mouse IgG1, Exbio, Prague, Czech Republic).
Regulation (control) of anti-NKR-P1A in NK cells
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440803 Disease Relevance 0.45 Pain Relevance 0

General Comments

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