INT101578

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 0
Speculated 6
Reported most in Body
Documents 26
Total Number 34
Disease Relevance 16.70
Pain Relevance 19.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
microglial cells 3
macrophages 2
brain 2
spleen 2
hippocampus 2
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 544 100.00 Very High Very High Very High
Cannabinoid 518 100.00 Very High Very High Very High
Analgesic 175 100.00 Very High Very High Very High
Endocannabinoid 168 100.00 Very High Very High Very High
Cannabinoid receptor 110 100.00 Very High Very High Very High
Neuropathic pain 216 99.96 Very High Very High Very High
Peripheral nervous system 13 99.92 Very High Very High Very High
Multiple sclerosis 270 99.84 Very High Very High Very High
Pain 310 99.80 Very High Very High Very High
antagonist 302 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 292 99.96 Very High Very High Very High
Demyelinating Disease 222 99.84 Very High Very High Very High
Pain 370 99.80 Very High Very High Very High
Nociception 64 99.00 Very High Very High Very High
Diabetes Mellitus 154 98.80 Very High Very High Very High
Stress 422 98.16 Very High Very High Very High
Anxiety Disorder 32 98.00 Very High Very High Very High
Targeted Disruption 115 97.92 Very High Very High Very High
Chronic Disease 3 97.40 Very High Very High Very High
Motor Neuron Diseases 176 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether CB2-R gene targeting by CB2-R antisense oligonucleotide (oligo) modifies behavior, we determined whether inhibition of CB2 gene expression in the brain will alter mouse behavior in the elevated plus-maze test.
Spec (whether) Regulation (targeting) of CB2-R in brain
1) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.43 Pain Relevance 0.29
The influence of CB2-R ligands on food consumption was also investigated.
Spec (investigated) Regulation (influence) of CB2-R
2) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.52 Pain Relevance 0.27
CB2-R gene targeting by CB2 antisense oligonucleotide modifies behavior
Regulation (targeting) of CB2-R
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.41 Pain Relevance 0.32
CB2-R gene targeting by CB2 antisense oligonucleotide modifies behavior
Regulation (modifies) of CB2-R
4) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.41 Pain Relevance 0.33
To further examine the role of CB1 and CB2 receptors in antinociception, we evaluated the efficacy of the non-selective cannabinoid receptor agonist, CP 55,940, in models of acute, inflammatory, and neuropathic pain in control mice, CB1 receptor knockout mice, and CB2 receptor knockout mice.
Spec (examine) Regulation (role) of CB2 associated with targeted disruption, antinociception, inflammation, cannabinoid receptor, neuropathic pain and agonist
5) Confidence 0.44 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19538975 Disease Relevance 0.68 Pain Relevance 0.84
In separate experiments we investigated the effects of selected CB2-R agonist or antagonists on anhedonia induced by chronic mild stress.
Spec (investigated) Regulation (effects) of CB2-R associated with stress, antagonist and agonist
6) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.83 Pain Relevance 0.31
The mechanism by which CB2 receptor agonists modulate neuropathic pain is uncertain, but is likely to be related to inhibition of inflammatory cell activity.
Regulation (modulate) of CB2 associated with inflammation, neuropathic pain and agonist
7) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 2.42 Pain Relevance 1.72
Anti-CB2 small interfering RNA blocked effect of CB2 agonist JWH-015 treatment
Regulation (effect) of CB2 associated with agonist
8) Confidence 0.36 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.07 Pain Relevance 0.05
CB2 small interfering RNA
Regulation (interfering) of CB2
9) Confidence 0.36 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.05
Secondly, SR141716, which is a selective CB1 receptor antagonist, and SR144528, which is a selective CB2 receptor antagonist, prevented R(+)?
Regulation (selective) of CB2 associated with antagonist
10) Confidence 0.34 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 1.18 Pain Relevance 0.56
Even cannabinoids effects on CB1/CB2 can potentially lead to the activation of PPARs.
Regulation (effects) of CB2 associated with cannabinoid
11) Confidence 0.31 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0.07 Pain Relevance 0.37
It is important to note that we previously demonstrated and reported that CB2-R immunoreactivity was present in the CA2 region of the hippocampus, spleen and interpolar part of spinal 5th nucleus of wild type brain and the CB2-R immunoreactivity was absent in these structures in the global CB2-R knockout mouse [24].
Regulation (immunoreactivity) of CB2-R in spleen associated with targeted disruption and hippocampus
12) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.17 Pain Relevance 0.36
CB2 gene expression and regulation by drug and alcohol treatment
Regulation (regulation) of CB2 gene associated with alcohol
13) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.14 Pain Relevance 0.32
It is important to note that we previously demonstrated and reported that CB2-R immunoreactivity was present in the CA2 region of the hippocampus, spleen and interpolar part of spinal 5th nucleus of wild type brain and the CB2-R immunoreactivity was absent in these structures in the global CB2-R knockout mouse [24].
Regulation (immunoreactivity) of CB2-R in spleen associated with targeted disruption and hippocampus
14) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.22 Pain Relevance 0.32
Thus, in the brain areas analyzed CB2-R immunoreactivity was detected in mice and rat brains, and this is supported by reports of identification of neuronal CB2-Rs in the brain stem involved in emesis [21].


Spec (analyzed) Regulation (immunoreactivity) of CB2-R in brains associated with vomiting
15) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.16 Pain Relevance 0.36
However, analysis of secondary structure of CB2 gene with Chou-Fasman, Robson and hydrophilic/ hydrophobic structure extimation methods using computer program GENETYX (Genetyx corporation, Tokyo, Japan) revealed a potential structural change in CB2 gene only by the Q63R but not by the H316Y polymorphism of the gene.
Regulation (change) of CB2 gene
16) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.09 Pain Relevance 0.14
However, many features of the CB2 gene structure, regulation and variation are beginning to emerge with identification of neuronal CB2-Rs in CNS [27], [28].
Regulation (regulation) of CB2 gene in neuronal
17) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.40 Pain Relevance 0.50
The immunohistochemical studies showed a greater number of microglial cells/macrophages containing COX-2 and CB2 immunoreactivity in MS compared to control spinal cord.
Regulation (immunoreactivity) of CB2 in macrophages associated with multiple sclerosis and spinal cord
18) Confidence 0.23 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 0.63 Pain Relevance 0.42
The role of CB1 and CB2 receptors was examined using the antagonists/inverse agonists, rimonabant and SR144528.
Spec (examined) Regulation (role) of CB2 associated with antagonist and agonist
19) Confidence 0.22 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0 Pain Relevance 0.13
CB2 knockout mice exhibit exacerbated neuropathic pain behaviour, including mirror image pain and enhanced microglia and astrocyte activation, suggesting that up-regulation of CB2 receptors in the spinal cord in models of neuropathic pain plays an important role in regulating neuropathic pain behaviour [68].
Regulation (regulation) of CB2 in astrocyte associated with targeted disruption, pain, neuropathic pain and spinal cord
20) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 1.13 Pain Relevance 1.23

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