INT101582

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.34
Pain Relevance 2.12

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endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
ulnar nerves 1
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 4 100.00 Very High Very High Very High
Kinase C 69 99.64 Very High Very High Very High
Morphine 7 95.92 Very High Very High Very High
antagonist 3 95.44 Very High Very High Very High
dysesthesia 2 94.16 High High
medulla 1 92.44 High High
qutenza 2 92.16 High High
Calcitonin gene-related peptide 5 89.12 High High
Neurolysis 2 88.48 High High
Neurotransmitter 3 87.56 High High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 5 99.64 Very High Very High Very High
Schizophrenia 7 99.32 Very High Very High Very High
Virus Diseases 89 98.76 Very High Very High Very High
Glioblastoma 3 95.28 Very High Very High Very High
Disease 202 95.00 High High
Dysesthesia 4 94.16 High High
Dysphagia 2 92.88 High High
Injury 8 92.60 High High
Uterine Fibroids 4 92.24 High High
Nociception 3 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The degrees of impairment were graded using a modified version of Dumitru's and Wilbourn's scale (mild: normal to slight decrease of SNAP amplitude and CMAP amplitude, and occasional denervation; moderate: profound decrease of SNAP amplitude and CMAP amplitude, constant denervation, and normal to slight decrease in motor unit recruitment; severe: absent SNAP amplitude, absent CMAP amplitude, marked denervation, and profound decrease or no volitional motor unit recruitment. mild = 1; moderate = 2; severe = 3).
Negative_regulation (decrease) of SNAP
1) Confidence 0.57 Published 2002 Journal Microsurgery Section Abstract Doc Link 11891869 Disease Relevance 0.24 Pain Relevance 0.09
The degrees of impairment were graded using a modified version of Dumitru's and Wilbourn's scale (mild: normal to slight decrease of SNAP amplitude and CMAP amplitude, and occasional denervation; moderate: profound decrease of SNAP amplitude and CMAP amplitude, constant denervation, and normal to slight decrease in motor unit recruitment; severe: absent SNAP amplitude, absent CMAP amplitude, marked denervation, and profound decrease or no volitional motor unit recruitment. mild = 1; moderate = 2; severe = 3).
Negative_regulation (decrease) of SNAP
2) Confidence 0.57 Published 2002 Journal Microsurgery Section Abstract Doc Link 11891869 Disease Relevance 0.29 Pain Relevance 0.08
The sensory nerve action potential (SNAP) amplitudes of median and ulnar nerves were decreased.
Negative_regulation (decreased) of SNAP in ulnar nerves associated with action potential
3) Confidence 0.45 Published 2008 Journal J. Neurol. Sci. Section Abstract Doc Link 18722628 Disease Relevance 0.69 Pain Relevance 0.32
Furthermore, the antidromic SNAP of Med-D4 was significantly reduced in amplitude on the affected side, and supported the diagnosis of the C8 plexopathy.
Negative_regulation (reduced) of SNAP
4) Confidence 0.42 Published 2007 Journal Rinsho Shinkeigaku Section Abstract Doc Link 17511287 Disease Relevance 0.06 Pain Relevance 0.06
In particular, the levels of protein SNAP-25 was shown to be reduced in both BIP and SCHZ [17].
Negative_regulation (reduced) of protein SNAP-25 associated with manic depressive disorder and schizophrenia
5) Confidence 0.31 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816673 Disease Relevance 2.38 Pain Relevance 0.04
Immunoblotting analysis with specific antibody to Ser187, a protein kinase C (PKC) phosphorylation site of SNAP-25, revealed that the specific phosphorylation was correspondingly decreased, which was correlated with morphine-induced inhibition of PKC activity.
Negative_regulation (site) of SNAP-25 associated with kinase c and morphine
6) Confidence 0.25 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.73
Together, these findings suggest that BDV mediated interference with PKC-dependent phosphorylation, by reducing phospho-SNAP-25 levels, leads to calcium hyper-responsiveness and that mutation of the BDV P phosphorylation sites restores normal calcium responses.


Negative_regulation (reducing) of phospho-SNAP-25 associated with virus diseases and kinase c
7) Confidence 0.23 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.28 Pain Relevance 0.19
Four genes (SNAP25, KRT8, KRT18 and CDH2) were significantly decreased in degenerate human NP cells, while three genes (VCAN, TNMD and BASP1) were significantly increased in degenerate human AF cells.
Negative_regulation (decreased) of SNAP25
8) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
This excitatory action could be prevented by cleaving synaptosomal-associated protein of M(r) 25,000 (SNAP-25) with botulinum neurotoxin (BoNT) type A, a potent inhibitor of exocytosis.
Negative_regulation (inhibitor) of SNAP-25
9) Confidence 0.10 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19369567 Disease Relevance 0.41 Pain Relevance 0.61

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