INT101590

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 9.35
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINB5) extracellular region (SERPINB5) extracellular matrix organization (SERPINB5)
cytoplasm (SERPINB5)
Anatomy Link Frequency
acinar cell 1
basal cell 1
SERPINB5 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 156 98.92 Very High Very High Very High
Chronic pancreatitis 12 95.60 Very High Very High Very High
Arthritis 15 95.52 Very High Very High Very High
Inflammation 72 93.48 High High
Pain 1 82.56 Quite High
cytokine 87 9.84 Low Low
metalloproteinase 75 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
methotrexate 12 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 85 100.00 Very High Very High Very High
Cancer 81 100.00 Very High Very High Very High
Pancreatic Cancer 19 99.84 Very High Very High Very High
Serous Cystadenoma 3 99.66 Very High Very High Very High
Adenocarcinoma 13 99.40 Very High Very High Very High
Rheumatoid Arthritis 156 98.92 Very High Very High Very High
Prostate Cancer 19 98.40 Very High Very High Very High
Severe Combined Immunodeficiency 24 98.20 Very High Very High Very High
Acinar Cell Carcinoma 6 97.98 Very High Very High Very High
Metastasis 12 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical evaluation of the maspin expression in pancreatic neoplasms has never been performed.
Gene_expression (expression) of maspin associated with pancreatic cancer
1) Confidence 0.75 Published 2002 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 11893038 Disease Relevance 0.82 Pain Relevance 0
In contrast, acinar cell carcinoma, pancreatic endocrine tumors, solid-pseudopapillary tumors, and serous cystadenomas demonstrated no maspin expression.
Neg (no) Gene_expression (expression) of maspin in acinar cell associated with serous cystadenoma, cancer and acinar cell carcinoma
2) Confidence 0.75 Published 2002 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 11893038 Disease Relevance 1.57 Pain Relevance 0.16
Maspin was expressed in all ductal adenocarcinomas, of which 78.9% (30/38) were high expressors and 21.1% (8/38) were low expressors.
Gene_expression (expressed) of Maspin associated with adenocarcinoma
3) Confidence 0.75 Published 2002 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 11893038 Disease Relevance 1.28 Pain Relevance 0.06
Maspin expression has been documented using immunohistochemical studies in pancreatic adenocarcinoma and high-grade intraductal dysplasia.
Gene_expression (expression) of Maspin associated with adenocarcinoma and cleidocranial dysplasia
4) Confidence 0.75 Published 2007 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 17536309 Disease Relevance 1.00 Pain Relevance 0.23
Consistent with the over-expression of proto-oncogenes is the lack or deficiency of tumour-suppressor genes such as p53 and its proapoptotic effector molecule p53-upregulated modulator of apoptosis (PUMA), maspin, and phosphatase and tensin homolog (PTEN) [62].
Gene_expression (-) of maspin associated with cancer and apoptosis
5) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.19 Pain Relevance 0.22
Consistent with the over-expression of proto-oncogenes is the lack or deficiency of tumour-suppressor genes such as p53 and its proapoptotic effector molecule p53-upregulated modulator of apoptosis (PUMA), maspin, and phosphatase and tensin homolog (PTEN) [62].
Gene_expression (over) of maspin associated with cancer and apoptosis
6) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.19 Pain Relevance 0.22
Consistent with the over-expression of proto-oncogenes is the lack or deficiency of tumour-suppressor genes such as p53 and its proapoptotic effector molecule p53-upregulated modulator of apoptosis (PUMA), maspin, and phosphatase and tensin homolog (PTEN) [62].
Gene_expression (expression) of maspin associated with cancer and apoptosis
7) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.19 Pain Relevance 0.22
Promoted by the fact that the basal cell layer is the sole source of tumor suppressor p63 and maspin in prostate 31-33, and that the absence of the basal cell layers is one of the most distinct morphological signs of invasive cancers, our resent studies have attempted to identify the early signs of tumor capsule disruptions.
Gene_expression (source) of maspin in basal cell associated with cancer
8) Confidence 0.58 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2931352 Disease Relevance 1.12 Pain Relevance 0.08

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