INT101592

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 6
Speculated 7
Reported most in Body
Documents 82
Total Number 150
Disease Relevance 70.61
Pain Relevance 22.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
MCF-7 11
neurons 10
plasma 4
sensory neurons 4
nerve 4
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 164 100.00 Very High Very High Very High
qutenza 97 100.00 Very High Very High Very High
addiction 78 99.92 Very High Very High Very High
Pain 551 99.84 Very High Very High Very High
agonist 219 99.72 Very High Very High Very High
trigeminal ganglion 15 99.72 Very High Very High Very High
c fibre 174 99.34 Very High Very High Very High
nociceptor 23 99.16 Very High Very High Very High
imagery 344 99.12 Very High Very High Very High
dorsal root ganglion 111 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 1700 99.96 Very High Very High Very High
Cancer 1145 99.84 Very High Very High Very High
Reprotox - General 1 523 99.84 Very High Very High Very High
Bladder Disease 510 99.84 Very High Very High Very High
Pain 453 99.84 Very High Very High Very High
Adenocarcinoma 612 99.76 Very High Very High Very High
Ganglion Cysts 129 99.72 Very High Very High Very High
Malignant Neoplastic Disease 107 99.64 Very High Very High Very High
Nociception 34 99.42 Very High Very High Very High
Hyperalgesia 20 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The responsiveness of C-nociceptors to menthol suggests an abnormal expression or function of TRPM8 channels in this patient with a small-fiber polyneuropathy.
Gene_expression (expression) of TRPM8 in nociceptors associated with neuropathy and c fibre
1) Confidence 0.78 Published 2009 Journal Pain Section Abstract Doc Link 19700243 Disease Relevance 0.66 Pain Relevance 0.76
Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement.
Gene_expression (expression) of TRPM8 in epithelial cells
2) Confidence 0.78 Published 2005 Journal Endocr. Relat. Cancer Section Title Doc Link 15947109 Disease Relevance 0.14 Pain Relevance 0.09
Our findings show that trpm8 gene expression requires a functional androgen receptor.
Gene_expression (expression) of trpm8
3) Confidence 0.78 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.14 Pain Relevance 0.08
Single-cell reverse transcriptase PCR and immunohistochemical experiments also showed that the trpm8 gene was mainly expressed in the apical secretory epithelial cells of the human prostate and trpm8 down-regulation occurred during the loss of the apical differentiated phenotype of the primary cultured human prostate epithelial cells.
Gene_expression (expressed) of trpm8 in epithelial cells
4) Confidence 0.78 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.22 Pain Relevance 0.07
This study was designed to determine the androgen-regulation mechanisms for TRPM8 mRNA expression and to identify the phenotype of TRPM8-expressing cells in the human prostate.
Gene_expression (expressing) of TRPM8
5) Confidence 0.78 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.09 Pain Relevance 0.08
The androgen-regulated trpm8 expression mechanisms are important in understanding the progression of prostate cancer to androgen-independence.
Gene_expression (expression) of trpm8 associated with reprotox - general 1
6) Confidence 0.78 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.25 Pain Relevance 0.06
In contrast, GFP-tagged TRPM8 heterologously expressed in HEK-293 cells target the PM.
Gene_expression (expressed) of TRPM8
7) Confidence 0.78 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.14 Pain Relevance 0.13
We also demonstrate that TRPM8 expression and the magnitude of SOC current associated with it are androgen-dependent.
Gene_expression (expression) of TRPM8
8) Confidence 0.78 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.14 Pain Relevance 0.13
Surprisingly, the human orthologue of rodent TRPM8 also appears to be strongly expressed in the prostate and in the prostate cancer-derived epithelial cell line, LNCaP.
Gene_expression (expressed) of TRPM8 in epithelial cell associated with reprotox - general 1
9) Confidence 0.78 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.17 Pain Relevance 0.17
This can be supported by the fact that capsaicin prevents the cold response in guinea-pig bladders pre-treated with menthol [18], suggesting that TRPM8 might be expressed in the C-afferent neurons, which also express TRPV1.
Gene_expression (expressed) of TRPM8 in afferent neurons associated with qutenza
10) Confidence 0.78 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.46 Pain Relevance 0.24
Alternatively, visceral (pelvic) afferents may be polymodal, and normally express both TRPV1 and TRPM8, with increases of both receptors in pathological states [31].
Gene_expression (express) of TRPM8 in visceral
11) Confidence 0.78 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.52 Pain Relevance 0.36
The regulators of TRPM8 expression in the bladder are not known.
Gene_expression (expression) of TRPM8 in bladder
12) Confidence 0.78 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 1.00 Pain Relevance 0.64
TRPM8 has been shown to be predominantly expressed in small-diameter neurons in sacral DRG in guinea pig, while the staining in large diameter cells was diffuse or absent [18].
Neg (absent) Gene_expression (expressed) of TRPM8 in neurons
13) Confidence 0.78 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.14 Pain Relevance 0.27
It may be hypothesized that in PBS patients, the high NGF levels [28,29] lead to a phenotypic change in sensory fibres which normally express TRPV1 alone, but which now also express TRPM8 [30], resulting in a similar increase of both receptors.
Gene_expression (express) of TRPM8 associated with bladder disease
14) Confidence 0.78 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.67 Pain Relevance 0.46
GDS, ISS, and SLC were responsible for the design and production of the TRPM8 antibodies used, CDB and CB helped conceive the study, with interpretation of the data, and writing the manuscript.
Gene_expression (production) of TRPM8
15) Confidence 0.78 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.53 Pain Relevance 0.44
TRPM8-immunoreactivity was found in a subset of both NF200-negative and -positive neurons, and it was concluded that TRPM8 was expressed in cell bodies of A delta and C fibres.
Gene_expression (expressed) of TRPM8 in neurons associated with c fibre
16) Confidence 0.78 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.08 Pain Relevance 0.41
Statistical analysis revealed that the over-expression of TRPM8 in tumoral tissues was observed in 65.4% of the 26 ductal adenocarcinomas tested.
Gene_expression (over) of TRPM8 associated with adenocarcinoma
17) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.39 Pain Relevance 0.04
estradiol (E2) is known to be the main physiological steroid in the breast, we studied the effects of adding E2 on TRPM8 expression in MCF-7 cells cultured under steroid-free conditions.
Gene_expression (expression) of TRPM8 in MCF-7
18) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0 Pain Relevance 0
Moreover, when analysing the expression of TRPM8 according to breast cancer grades, we found that TRPM8 is rather over-expressed in grade I (well differentiated) and II (moderately differentiated) than in grade III (poorly differentiated).
Gene_expression (expression) of TRPM8 associated with breast cancer
19) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.94 Pain Relevance 0
We then examined the expression of TRPM8 channels in human tumoral and adjacent non-tumoral breast tissues.
Spec (examined) Gene_expression (expression) of TRPM8
20) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.27 Pain Relevance 0.04

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