INT101593

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 29
Disease Relevance 13.79
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
neurons 4
nerve 3
visceral 2
MCF-7 2
epithelial cells 2
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 39 100.00 Very High Very High Very High
sodium channel 1 100.00 Very High Very High Very High
trigeminal ganglion 4 99.72 Very High Very High Very High
Pain 127 98.36 Very High Very High Very High
Central nervous system 2 96.30 Very High Very High Very High
Spontaneous pain 2 95.92 Very High Very High Very High
Shooting pain 1 94.48 High High
addiction 14 93.12 High High
qutenza 13 93.04 High High
Hyperalgesia 3 91.12 High High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 34 100.00 Very High Very High Very High
Cancer 242 99.84 Very High Very High Very High
Reprotox - General 1 116 99.84 Very High Very High Very High
Ganglion Cysts 8 99.72 Very High Very High Very High
Adenocarcinoma 126 99.56 Very High Very High Very High
Bladder Disease 136 99.52 Very High Very High Very High
Breast Cancer 350 98.72 Very High Very High Very High
Pain 106 98.36 Very High Very High Very High
Nociception 5 98.22 Very High Very High Very High
Disease 5 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings show that trpm8 gene expression requires a functional androgen receptor.
Positive_regulation (requires) of Gene_expression (expression) of trpm8
1) Confidence 0.70 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.14 Pain Relevance 0.08
We found that TRPM8 over-expression was observed in 77.8% of the ER?
Positive_regulation (over) of Gene_expression (over) of TRPM8
2) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.58 Pain Relevance 0.03
TRPM8 mRNA expression increased after 24 h (219.4 ± 6.7% of control, p < 0.05) and 48 h (298.3 ± 30.2% of control, p < 0.01) of incubation with E2 (Fig. 3Ba).
Positive_regulation (increased) of Gene_expression (expression) of TRPM8 mRNA
3) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.07 Pain Relevance 0
estradiol enhanced TRPM8 expression in a steroid-deprived MCF-7 cells
Positive_regulation (enhanced) of Gene_expression (expression) of TRPM8 in MCF-7
4) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.07 Pain Relevance 0.03
Cells overexpressing the TRPM8 channel can be activated by cold temperatures and by a cooling agent, menthol.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TRPM8
5) Confidence 0.58 Published 2002 Journal Cell Section Abstract Doc Link 11893340 Disease Relevance 0.10 Pain Relevance 0.18
TRPM8 mRNA has also been shown to be overexpressed in prostate cancer and is considered to play an important role in prostate physiology.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TRPM8 associated with reprotox - general 1
6) Confidence 0.50 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.10 Pain Relevance 0.09
Yet, silencing of endogenous TRPM8 mRNA by either antisense or siRNA strategies suppresses both I(cold/menthol) and TRPM8 protein in LNCaP cells.
Positive_regulation (silencing) of Gene_expression (silencing) of TRPM8
7) Confidence 0.50 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.16 Pain Relevance 0.15
They observed TRPM8 immunoreactivity in a subset of neurons with diameter of cell bodies in the range of 22.1 ± 4 ?
Positive_regulation (observed) of Gene_expression (immunoreactivity) of TRPM8 in neurons
8) Confidence 0.50 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.10 Pain Relevance 0.33
Alternatively, visceral (pelvic) afferents may be polymodal, and normally express both TRPV1 and TRPM8, with increases of both receptors in pathological states [31].
Positive_regulation (increases) of Gene_expression (express) of TRPM8 in visceral
9) Confidence 0.50 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.52 Pain Relevance 0.36
They observed TRPM8 immunoreactivity in a subset of neurons with diameter of cell bodies in the range of 22.1 ± 4 ?
Positive_regulation (observed) of Gene_expression (observed) of TRPM8 in neurons
10) Confidence 0.50 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.10 Pain Relevance 0.32
In addition, an increase in TRPM8-immunoreactive nerve fibres in IDO and PBS, suggests that TRPM8 may contribute to the increased frequency which is a prominent symptom in these conditions.
Positive_regulation (increase) of Gene_expression (fibres) of TRPM8-immunoreactive in nerve associated with bladder disease
11) Confidence 0.50 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.64 Pain Relevance 0.20
TRPM8 expression is regulated by ER?
Positive_regulation (by) of Gene_expression (expression) of TRPM8
12) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.17 Pain Relevance 0.05
A variety of distinct pathophysiological mechanisms in the peripheral and central nervous system operate in concert: In some patients the nerve lesion triggers molecular changes in nociceptive neurons that become abnormally sensitive and develop pathological spontaneous activity (upregulation of sodium channels and receptors, e.g., vanilloid TRPV1 receptors, menthol-sensitive TRPM8 receptors, or alpha-receptors).
Positive_regulation (upregulation) of in central nervous system Gene_expression (receptors) of TRPM8 in nerve associated with nociception, sodium channel and central nervous system
13) Confidence 0.49 Published 2009 Journal Handb Exp Pharmacol Section Abstract Doc Link 19655103 Disease Relevance 1.45 Pain Relevance 1.33
Overexpression of TRPM8 was independent of changes in androgen receptor (AR) mRNA levels in tumor tissue.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of TRPM8 associated with cancer
14) Confidence 0.48 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043080 Disease Relevance 0.84 Pain Relevance 0.09
Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement.
Positive_regulation (requirement) of Gene_expression (expression) of TRPM8 in epithelial cells
15) Confidence 0.47 Published 2005 Journal Endocr. Relat. Cancer Section Title Doc Link 15947109 Disease Relevance 0.14 Pain Relevance 0.10
We also demonstrate that TRPM8 expression and the magnitude of SOC current associated with it are androgen-dependent.
Positive_regulation (dependent) of Gene_expression (expression) of TRPM8
16) Confidence 0.47 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.14 Pain Relevance 0.13
In steroid deprived medium, addition of 17-beta-estradiol (E2, 10 nM) increased both TRPM8 mRNA expression and the number of cells which respond to Icilin, but failed to affect the Ca2+ entry amplitude.
Neg (failed) Positive_regulation (increased) of Gene_expression (expression) of TRPM8 mRNA
17) Confidence 0.47 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2887400 Disease Relevance 0.42 Pain Relevance 0.14
Furthermore, we have provided evidence of ER mediated increase in TRPM8 mRNA expression.
Positive_regulation (increase) of Gene_expression (expression) of TRPM8 mRNA
18) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.42 Pain Relevance 0.04
We found that TRPM8 over-expression was observed in 77.8% of the ER?
Positive_regulation (over) of Gene_expression (-) of TRPM8
19) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.58 Pain Relevance 0.03
We found that TRPM8 over-expression was observed in 77.8% of the ER?
Positive_regulation (expression) of Gene_expression (over) of TRPM8
20) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

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