INT101594

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 16.14
Pain Relevance 4.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
CD86 6
T cells 5
fibroblasts 2
monocyte 2
B-cells 2
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 60 99.96 Very High Very High Very High
Inflammation 451 99.62 Very High Very High Very High
diclofenac 22 98.58 Very High Very High Very High
cytokine 359 98.12 Very High Very High Very High
tolerance 37 96.64 Very High Very High Very High
Arthritis 73 95.72 Very High Very High Very High
agonist 97 95.44 Very High Very High Very High
Inflammatory mediators 14 91.92 High High
rheumatoid arthritis 66 86.64 High High
chemokine 81 83.92 Quite High
Disease Link Frequency Relevance Heat
Adhesions 45 100.00 Very High Very High Very High
Alzheimer's Dementia 94 99.96 Very High Very High Very High
Acute Coronary Syndrome 2 99.84 Very High Very High Very High
Epstein-barr Virus 103 99.66 Very High Very High Very High
INFLAMMATION 521 99.62 Very High Very High Very High
Eye Disease 126 99.54 Very High Very High Very High
Mycobacterial Infection 79 98.24 Very High Very High Very High
Hypertension 7 97.20 Very High Very High Very High
Influenza Virus Infection 65 97.16 Very High Very High Very High
Coagulation Disorder 3 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In previous studies we demonstrated that chemical manipulation in DCs through inhibition of IKK, which is responsible for CD40 upregulation in DC, can result in generation of antigen-specific immune regulation and suppression of pathology in the CIA model [15].
Positive_regulation (upregulation) of CD40 associated with arthritis
1) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.64 Pain Relevance 0.24
We also expect to see increased CD40, which communicates from the antigen presenting cell to CD40 ligand on T cells.
Positive_regulation (increased) of CD40 in T cells
2) Confidence 0.55 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.71 Pain Relevance 0.05
In sedentary TG animals, a trend of reduced expression of CD40 is present compared to WTSED (p = 0.10), but there is a significant elevation in CD40 from TGSED to TGRUN (p = 0.008) (Figure 4).
Positive_regulation (elevation) of CD40
3) Confidence 0.55 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.07 Pain Relevance 0.11
PMA, which is known to cause B cell activation [36], resulted in the upregulation of CD40, CD86, and CD80 and the downregulation of MHC II.
Positive_regulation (upregulation) of CD40 in CD86
4) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.07 Pain Relevance 0.11
Reduced CII antibody production and generation of Treg by treatment of CD40 siRNA
Positive_regulation (treatment) of CD40 siRNA in CII
5) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.91 Pain Relevance 0.19
When 0.50 mg DF was co-injected with TNP-Ficoll, mice orally pretreated with DF, compared to vehicle-pretreated mice, and had a significantly greater increase in IgM anti-TNP AFCs on day 4, and a significant increase in both IgG1 and IgG3 anti-TNP AFCs on day 7.
Positive_regulation (increase) of IgM associated with diclofenac
6) Confidence 0.49 Published 2002 Journal Toxicology Section Abstract Doc Link 11893420 Disease Relevance 0 Pain Relevance 0.53
This form of microglial activation in CD40L-sufficient AD mice is pathogenic, as CD40L-deficient AD mice demonstrate reduced activated (CD11b+) microglia, an effect that is associated with mitigated abnormal hyper-phosphorylation of tau protein (a key indicator of neuronal stress) [42].
Positive_regulation (activation) of CD40L-sufficient in neuronal associated with stress and alzheimer's dementia
7) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.16 Pain Relevance 0.13
These effects on enhanced cytokine production could be blocked by the addition of an antagonistic CD40 antibody, confirming the requirement of the CD40-CD40L interaction per se in this phenomenon.
Positive_regulation (requirement) of CD40 associated with cytokine
8) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.28 Pain Relevance 0.28
-induced microglial CD40 expression [25,26].
Positive_regulation (induced) of CD40
9) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.84 Pain Relevance 0.25
We believe that activation markers (such as the informative CD40 and HLA-DR) for a principal reason are able to provide more reliable and easy-to-evaluate information than values expressed as percentage of all lymphocytes or leukocytes.
Positive_regulation (informative) of CD40 in lymphocytes
10) Confidence 0.41 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.70 Pain Relevance 0
300×300 µm2) used for Xenogen CD40 imaging and TTC staining experiments, and 10 mg/ml for the single arteriole clotting experiments.
Positive_regulation (used) of CD40 in arteriole associated with coagulation disorder and imagery
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.19 Pain Relevance 0.19
In summary, flavonoids apigenin and luteolin may prevent microglial-mediated inflammation by modulating the induction of CD40 in response IFN-?.
Positive_regulation (induction) of CD40 associated with inflammation
12) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.58 Pain Relevance 0.20
In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators.


Positive_regulation (effective) of CD40
13) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2569027 Disease Relevance 0.49 Pain Relevance 0.16
Interestingly, we could not document any increase in CD154 (the CD40 ligand) on T cells, and therefore decided not to include CD154 in our standard panel.
Positive_regulation (increase) of CD40 in T cells
14) Confidence 0.38 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.27 Pain Relevance 0.03
The CD16+ monocyte subset similarly showed an increase in CD40, but with a larger inter-individual variation (results not shown).
Positive_regulation (increase) of CD40 in monocyte
15) Confidence 0.38 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.83 Pain Relevance 0
Patients infected with gram-negative bacteria or EBV showed a marked increase in monocyte CD40, while this effect was less pronounced for tuberculosis, borrelia and influenza.
Positive_regulation (increase) of CD40 in monocyte associated with mycobacterial infection, influenza virus infection and epstein-barr virus
16) Confidence 0.38 Published 2010 Journal BMC Infect Dis Section Abstract Doc Link PMC2912311 Disease Relevance 1.04 Pain Relevance 0.12
Increased CD40 and MHCII, markers of antigen presentation, were observed in TGRUN animals compared to TGSED, as well as CD11c staining in and around plaques and vasculature.
Positive_regulation (Increased) of CD40 in plaques
17) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2329612 Disease Relevance 0.19 Pain Relevance 0.09
In a mixed CD40+CD40?
Positive_regulation (mixed) of CD40
18) Confidence 0.33 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.21 Pain Relevance 0
This is consistent with an interpretation for a requirement for CD40-mediated signaling and participation in germinal centers of infected mice for long-term maintenance of ?
Positive_regulation (requirement) of CD40
19) Confidence 0.33 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.13 Pain Relevance 0
In a mixed CD40+CD40?
Positive_regulation (mixed) of CD40
20) Confidence 0.33 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.21 Pain Relevance 0

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