INT101602

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 4.10
Pain Relevance 8.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
dorsal horn 4
neurons 2
spinal cord 1
brain 1
skeletal muscle 1
Cdk5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 18 100.00 Very High Very High Very High
Sciatic nerve 16 100.00 Very High Very High Very High
Dorsal horn neuron 24 99.92 Very High Very High Very High
Morphine 23 99.84 Very High Very High Very High
Antinociceptive 14 99.48 Very High Very High Very High
cocaine 4 99.40 Very High Very High Very High
tolerance 18 98.84 Very High Very High Very High
cerebral cortex 1 98.56 Very High Very High Very High
Inflammation 10 97.64 Very High Very High Very High
Dorsal horn 4 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 16 99.98 Very High Very High Very High
Nervous System Injury 9 98.44 Very High Very High Very High
INFLAMMATION 8 97.64 Very High Very High Very High
Parkinson's Disease 3 97.52 Very High Very High Very High
Hyperalgesia 12 96.32 Very High Very High Very High
Disease 4 88.40 High High
Ganglion Cysts 1 82.84 Quite High
Poisoning 4 80.24 Quite High
Newborn Drug Withdrawal Syndrome 1 79.04 Quite High
Opiate Addiction 3 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cocaine resulted in a time dependent increase in brain Cdk5 activity which peaked on day 14.
Positive_regulation (increase) of Cdk5 in brain associated with cocaine
1) Confidence 0.70 Published 2006 Journal Neurotoxicol Teratol Section Abstract Doc Link 16962740 Disease Relevance 0.08 Pain Relevance 0.44
However, CDK5 contents and activities in SN of rats treated with 200 or 400mg/kg HD were significantly increased and positively correlated with gait abnormality in both the cytosolic and membrane fractions.
Positive_regulation (increased) of CDK5 associated with sciatic nerve
2) Confidence 0.69 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.29 Pain Relevance 0.41
Although increases of CDK5 contents in both the cytosolic and membrane fractions of SC in 200 and 400mg/kg HD-treated rats were also observed, CDK5 activities were significantly decreased in the cytosolic fraction and negatively correlated with gait abnormality.
Positive_regulation (increases) of CDK5 associated with spinal cord
3) Confidence 0.69 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.29 Pain Relevance 0.43
Northern blot analysis revealed that Cdk5 and p35 transcripts were up-regulated in muscle after nerve denervation.
Positive_regulation (up-regulated) of Cdk5 in nerve
4) Confidence 0.69 Published 2002 Journal Neuroreport Section Abstract Doc Link 11893918 Disease Relevance 0.17 Pain Relevance 0.08
Induction of Cdk5 activity in rat skeletal muscle after nerve injury.
Positive_regulation (Induction) of Cdk5 in skeletal muscle associated with nervous system injury
5) Confidence 0.69 Published 2002 Journal Neuroreport Section Title Doc Link 11893918 Disease Relevance 0.18 Pain Relevance 0.07
Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia.
Positive_regulation (Activation) of cyclin-dependent kinase 5 in dorsal horn associated with hyperalgesia, inflammation and dorsal horn neuron
6) Confidence 0.68 Published 2007 Journal Pain Section Title Doc Link 16996690 Disease Relevance 0.37 Pain Relevance 0.61
Following CFA injection, Cdk5 activity was upregulated in both primary sensory and dorsal horn neurons.
Positive_regulation (upregulated) of Cdk5 in dorsal horn associated with dorsal horn neuron
7) Confidence 0.68 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.36 Pain Relevance 0.69
Cdk5 activation in DRG neurons required p35, whereas p25 was required in the dorsal horn.
Positive_regulation (activation) of Cdk5 in dorsal horn associated with dorsal horn
8) Confidence 0.68 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.38 Pain Relevance 0.75
Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia.
Positive_regulation (Activation) of Cdk5 in dorsal horn associated with hyperalgesia, inflammation and dorsal horn neuron
9) Confidence 0.68 Published 2007 Journal Pain Section Title Doc Link 16996690 Disease Relevance 0.37 Pain Relevance 0.64
At the molecular level, transcriptional activation of striatal CREB and cdk5 may contribute to the persistent expression of these levodopa-induced response alterations.
Positive_regulation (activation) of cdk5
10) Confidence 0.65 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373527 Disease Relevance 0.54 Pain Relevance 0.19
Here, we show that cyclin-dependent kinase 5 (Cdk5), activated in morphine antinociceptive tolerance, directly phosphorylates DOR at Thr-161 in DRG neurons.
Positive_regulation (activated) of Cdk5 in neurons associated with tolerance, opioid receptor, antinociceptive and morphine
11) Confidence 0.65 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.29
To investigate the mechanisms of the neuropathy induced by HD, the contents and activities of cyclin-dependent kinase 5 (CDK5) and activators (p35 precursor, p35 and p25) in rats' cerebrum cortex (CC), spinal cord (SC) and sciatic nerve (SN) were determined.
Spec (investigate) Positive_regulation (induced) of CDK5 in spinal cord associated with neuropathic pain, sciatic nerve and spinal cord
12) Confidence 0.50 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.27 Pain Relevance 0.30
Although increases of CDK5 contents in both the cytosolic and membrane fractions of SC in 200 and 400mg/kg HD-treated rats were also observed, CDK5 activities were significantly decreased in the cytosolic fraction and negatively correlated with gait abnormality.
Positive_regulation (increases) of CDK5 associated with spinal cord
13) Confidence 0.50 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.30 Pain Relevance 0.45
Cyclin-dependent kinase 5 (Cdk5) was originally identified as a serine/threonine kinase and subsequently demonstrated to play a critical role in the development of CNS.
Positive_regulation (dependent) of Cdk5
14) Confidence 0.46 Published 2002 Journal Neuroreport Section Abstract Doc Link 11893918 Disease Relevance 0.15 Pain Relevance 0
When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.
Positive_regulation (increased) of Cdk5 in descending colon associated with action potential and spinal cord
15) Confidence 0.44 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.45
Here, we show that cyclin-dependent kinase 5 (Cdk5), activated in morphine antinociceptive tolerance, directly phosphorylates DOR at Thr-161 in DRG neurons.
Positive_regulation (activated) of cyclin-dependent kinase 5 in neurons associated with tolerance, opioid receptor, antinociceptive and morphine
16) Confidence 0.44 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.30
Acute treatment of rats with morphine (30 mg/kg, 2 h) increased the density of cdk5 (35%), but not that of p35, in the cerebral cortex.
Positive_regulation (increased) of cdk5 in cerebral cortex associated with cerebral cortex and morphine
17) Confidence 0.42 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.14 Pain Relevance 0.86

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