INT101603

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.12
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cdk5r1) nucleus (Cdk5r1) embryo development (Cdk5r1)
cell cycle (Cdk5r1) kinase activity (Cdk5r1) cytoplasm (Cdk5r1)
Anatomy Link Frequency
neurons 1
cerebral cortex 1
nerve 1
muscle 1
dorsal horn 1
Cdk5r1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 99.92 Very High Very High Very High
Morphine 2 99.66 Very High Very High Very High
cerebral cortex 1 99.64 Very High Very High Very High
Dorsal horn neuron 12 99.26 Very High Very High Very High
Dorsal horn 2 98.64 Very High Very High Very High
intrathecal 4 96.24 Very High Very High Very High
Opioid 5 90.84 High High
Hyperalgesia 6 82.96 Quite High
allodynia 2 80.40 Quite High
addiction 3 77.04 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 98.08 Very High Very High Very High
Hyperalgesia 6 82.96 Quite High
Neuropathic Pain 2 80.40 Quite High
Opiate Addiction 3 77.04 Quite High
INFLAMMATION 4 75.00 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our finding on the ability of tetrodotoxin to induce p35 transcript in muscle suggested that electrical activity could regulate p35 expression.
Positive_regulation (induce) of p35 in muscle associated with tetrodotoxin
1) Confidence 0.56 Published 2002 Journal Neuroreport Section Abstract Doc Link 11893918 Disease Relevance 0.16 Pain Relevance 0.10
Northern blot analysis revealed that Cdk5 and p35 transcripts were up-regulated in muscle after nerve denervation.
Positive_regulation (up-regulated) of p35 in nerve
2) Confidence 0.56 Published 2002 Journal Neuroreport Section Abstract Doc Link 11893918 Disease Relevance 0.17 Pain Relevance 0.08
The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative of p35, could only be detected in the dorsal horn neurons.
Positive_regulation (derivative) of p35 in neurons associated with dorsal horn neuron
3) Confidence 0.38 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.26 Pain Relevance 0.49
Cdk5 activation in DRG neurons required p35, whereas p25 was required in the dorsal horn.
Positive_regulation (required) of p35 in dorsal horn associated with dorsal horn
4) Confidence 0.38 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.38 Pain Relevance 0.81
Acute treatment of rats with morphine (30 mg/kg, 2 h) increased the density of cdk5 (35%), but not that of p35, in the cerebral cortex.
Positive_regulation (increased) of p35 in cerebral cortex associated with cerebral cortex and morphine
5) Confidence 0.37 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.14 Pain Relevance 0.87

General Comments

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