INT101604

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 2.20
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
brain 2
nerve 1
skeletal muscle 1
Cdk5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 22 99.98 Very High Very High Very High
cocaine 8 99.72 Very High Very High Very High
Glutamate 1 99.72 Very High Very High Very High
Stimulus evoked pain 1 99.48 Very High Very High Very High
induced neuropathy 3 99.20 Very High Very High Very High
Pain 6 99.12 Very High Very High Very High
analgesia 2 98.72 Very High Very High Very High
Antinociceptive 4 98.60 Very High Very High Very High
tolerance 10 98.16 Very High Very High Very High
qutenza 6 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Poisoning 3 99.58 Very High Very High Very High
Pain 7 99.48 Very High Very High Very High
Hypersensitivity 3 99.28 Very High Very High Very High
Neuropathic Pain 9 98.88 Very High Very High Very High
Nervous System Injury 6 98.48 Very High Very High Very High
Peripheral Neuropathy 3 96.76 Very High Very High Very High
Newborn Drug Withdrawal Syndrome 2 75.40 Quite High
Nociception 1 72.08 Quite High
Stress 9 52.04 Quite High
Shock 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The temporal profiles for the regulation of Cdk5 and p35 transcripts were different, suggesting that these changes in gene transcription might be regulated by different mechanism.
Regulation (regulation) of Cdk5
1) Confidence 0.61 Published 2002 Journal Neuroreport Section Abstract Doc Link 11893918 Disease Relevance 0.17 Pain Relevance 0.09
Here, we report the regulation of Cdk5 and p35 in rat skeletal muscle after nerve injury.
Regulation (regulation) of Cdk5 in skeletal muscle associated with nervous system injury
2) Confidence 0.61 Published 2002 Journal Neuroreport Section Abstract Doc Link 11893918 Disease Relevance 0.17 Pain Relevance 0.07
AIM: To investigate the effect of cyclin-dependent kinase 5 (Cdk5) inhibitor roscovitine on the morphine antinociceptive tolerance development in rats.
Spec (investigate) Regulation (effect) of Cdk5 associated with tolerance, antinociceptive and morphine
3) Confidence 0.45 Published 2004 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 15301735 Disease Relevance 0 Pain Relevance 0.38
AIM: To investigate the effect of cyclin-dependent kinase 5 (Cdk5) inhibitor roscovitine on the morphine antinociceptive tolerance development in rats.
Spec (investigate) Regulation (effect) of cyclin-dependent kinase 5 associated with tolerance, antinociceptive and morphine
4) Confidence 0.45 Published 2004 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 15301735 Disease Relevance 0 Pain Relevance 0.38
Thus, HD intoxication was associated with deregulation of CDK5 and its activator p35 or p25 in nerve tissues.
Regulation (deregulation) of CDK5 in nerve associated with poisoning
5) Confidence 0.45 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.28 Pain Relevance 0.42
Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats.
Regulation (Effects) of cyclin-dependent kinase 5 associated with tolerance, analgesia and morphine
6) Confidence 0.44 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16902054 Disease Relevance 0 Pain Relevance 1.44
The unique down-regulated pathways demonstrated a strong signaling component (G_alpha_5, G_alpha_i, glutamate), cell cycle control (cdk5, CRcellcylce) and steroid receptor signaling (FRASOR_DOWN).
Regulation (control) of cdk5 associated with glutamate
7) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.05 Pain Relevance 0.08
Prenatal cocaine and morphine alter brain cyclin-dependent kinase 5 (Cdk5) activity in rat pups.
Regulation (alter) of Cdk5 in brain associated with morphine and cocaine
8) Confidence 0.27 Published 2006 Journal Neurotoxicol Teratol Section Title Doc Link 16962740 Disease Relevance 0.08 Pain Relevance 0.46
Prenatal cocaine and morphine alter brain cyclin-dependent kinase 5 (Cdk5) activity in rat pups.
Regulation (alter) of cyclin-dependent kinase 5 in brain associated with morphine and cocaine
9) Confidence 0.27 Published 2006 Journal Neurotoxicol Teratol Section Title Doc Link 16962740 Disease Relevance 0.08 Pain Relevance 0.46
Involvement of cyclin-dependent kinase 5 in 2,5-hexanedione-induced neuropathy.
Regulation (Involvement) of cyclin-dependent kinase 5 associated with induced neuropathy and neuropathic pain
10) Confidence 0.27 Published 2008 Journal Toxicology Section Title Doc Link 18423835 Disease Relevance 0.29 Pain Relevance 0.38
The inconsistent changes of CDK5 activities in CNS and PNS might delegate the different mechanisms of HD-induced peripheral neuropathy.
Regulation (changes) of CDK5 associated with peripheral neuropathy
11) Confidence 0.27 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.32 Pain Relevance 0.41
Thus, the studies of the functional regulation of TRPV1 are mainly focused on two aspects: to develop more potent analogues of capsaicin with less side effects; or to elucidate the mechanisms of TRPV1 in pain sensitivity, especially of that TRPV1 as a target of various protein kinases such as PKD1 and Cdk5 is involved pain hypersensitivity.
Regulation (target) of Cdk5 associated with pain, qutenza, hypersensitivity and stimulus evoked pain
12) Confidence 0.03 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18528757 Disease Relevance 0.77 Pain Relevance 0.94

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