INT10161

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Context Info
Confidence 0.53
First Reported 1981
Last Reported 1997
Negated 1
Speculated 1
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 0.97
Pain Relevance 11.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cck, Penk) extracellular space (Cck)
Anatomy Link Frequency
spinal cord 3
nerves 1
pyloric sphincter 1
Cck (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 76 100.00 Very High Very High Very High
Cholecystokinin 69 100.00 Very High Very High Very High
opiate 9 99.84 Very High Very High Very High
medulla 3 99.68 Very High Very High Very High
Neuropeptide 1 99.60 Very High Very High Very High
Pain 6 99.28 Very High Very High Very High
Opioid 4 97.52 Very High Very High Very High
Spinal cord 3 96.96 Very High Very High Very High
antagonist 8 96.40 Very High Very High Very High
Central nervous system 2 82.80 Quite High
Disease Link Frequency Relevance Heat
Pain 6 99.28 Very High Very High Very High
Nociception 3 77.24 Quite High
Urological Neuroanatomy 3 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result suggested the possibility that Met-enkephalin, as well as other enkephalin analogues of similar structure, could associate with receptors for CCK.
CCK Binding (associate) of enkephalin associated with enkephalin and cholecystokinin
1) Confidence 0.53 Published 1992 Journal J. Protein Chem. Section Abstract Doc Link 1466765 Disease Relevance 0 Pain Relevance 1.10
To test this theoretical result, we examined the ability of Met-enkephalin and its analogues to bind to peripheral CCK receptors in the rat gastrointestinal tract; in particular, we measured the ability of the opiate peptide to inhibit the effects of CCK in a physiological assay system which we have previously characterized: CCK-induced contraction of the isolated rat pyloric sphincter.
CCK Spec (examined) Binding (bind) of enkephalin in pyloric sphincter associated with opiate, enkephalin and cholecystokinin
2) Confidence 0.46 Published 1992 Journal J. Protein Chem. Section Abstract Doc Link 1466765 Disease Relevance 0 Pain Relevance 1.15
Furthermore, antibodies against CCK were found to cross-react with Met-enkephalin and its analogues in a manner which suggests a distinct structure-activity relationship.
CCK Binding (react) of enkephalin associated with enkephalin and cholecystokinin
3) Confidence 0.46 Published 1992 Journal J. Protein Chem. Section Abstract Doc Link 1466765 Disease Relevance 0 Pain Relevance 1.36
This result suggested the possibility that Met-enkephalin, as well as other enkephalin analogues of similar structure, could associate with receptors for CCK.
CCK Binding (associate) of enkephalin associated with enkephalin and cholecystokinin
4) Confidence 0.36 Published 1992 Journal J. Protein Chem. Section Abstract Doc Link 1466765 Disease Relevance 0 Pain Relevance 1.10
The overlap of CCK- and ENK- immunoreactive terminals arbors provides a morphological substrate for an antagonistic interaction of CCK and ENK within brainstem pain modulating circuits, as has been demonstrated in the spinal cord.
CCK Binding (interaction) of ENK in spinal cord associated with pain, medulla, enkephalin, cholecystokinin and spinal cord
5) Confidence 0.34 Published 1997 Journal Neuroreport Section Abstract Doc Link 9331904 Disease Relevance 0.33 Pain Relevance 1.58
The overlap of CCK- and ENK- immunoreactive terminals arbors provides a morphological substrate for an antagonistic interaction of CCK and ENK within brainstem pain modulating circuits, as has been demonstrated in the spinal cord.
CCK Binding (interaction) of ENK in spinal cord associated with pain, medulla, enkephalin, cholecystokinin and spinal cord
6) Confidence 0.34 Published 1997 Journal Neuroreport Section Abstract Doc Link 9331904 Disease Relevance 0.33 Pain Relevance 1.58
The overlap of CCK- and ENK- immunoreactive terminals arbors provides a morphological substrate for an antagonistic interaction of CCK and ENK within brainstem pain modulating circuits, as has been demonstrated in the spinal cord.
CCK Binding (interaction) of ENK in spinal cord associated with pain, medulla, enkephalin, cholecystokinin and spinal cord
7) Confidence 0.33 Published 1997 Journal Neuroreport Section Abstract Doc Link 9331904 Disease Relevance 0.32 Pain Relevance 1.54
(b) The CCK immunoreactive nerves display a distribution similar to that of enkephalin, but the main endogenous CCK forms do not bind to opiate receptors.
CCK Neg (not) Binding (bind) of enkephalin in nerves associated with opiate and enkephalin
8) Confidence 0.32 Published 1981 Journal Peptides Section Abstract Doc Link 6267560 Disease Relevance 0 Pain Relevance 1.07
Thus, enkephalin and CCK interact to modulate amphetamine-induced locomotor stereotypy.
CCK Binding (interact) of enkephalin associated with enkephalin
9) Confidence 0.28 Published 1990 Journal Brain Res. Section Abstract Doc Link 2350675 Disease Relevance 0 Pain Relevance 0.67

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