INT101614

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 2.73
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Dpp4) extracellular region (Dpp4) cell adhesion (Dpp4)
Golgi apparatus (Dpp4) endoplasmic reticulum (Dpp4) plasma membrane (Dpp4)
Anatomy Link Frequency
T-cell 4
macrophages 1
livers 1
colon 1
B cells 1
Dpp4 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 40 98.44 Very High Very High Very High
Neuropeptide 7 97.20 Very High Very High Very High
cytokine 8 96.44 Very High Very High Very High
Neurotransmitter 3 95.20 Very High Very High Very High
bradykinin 8 91.20 High High
Dynorphin 21 75.00 Quite High
rheumatoid arthritis 3 72.08 Quite High
tolerance 54 65.28 Quite High
agonist 120 50.60 Quite High
Kappa opioid receptor 15 43.36 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 16 95.64 Very High Very High Very High
Metaplasia 2 94.44 High High
Targeted Disruption 27 84.44 Quite High
Constipation 8 81.60 Quite High
Nociception 11 75.00 Quite High
Rheumatoid Arthritis 3 72.08 Quite High
Diabetes Mellitus 212 69.04 Quite High
Hyperlipidemia 2 66.40 Quite High
Alcohol Addiction 2 65.12 Quite High
Obesity 19 64.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: CD26 is a multifunctional cell surface glycoprotein expressed by T and B cells.
Gene_expression (expressed) of CD26 in B cells
1) Confidence 0.78 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16154213 Disease Relevance 0.07 Pain Relevance 0
Moreover, by using monoclonal antibody immunoblots, CD26 was not detected in the livers of ZP-treated CD26-deficient mice.
Neg (not) Gene_expression (detected) of CD26 in livers
2) Confidence 0.74 Published 2002 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 11895555 Disease Relevance 0 Pain Relevance 0
The data obtained have shown that R1.1 cells express high density of surface CD26 as compared to normal thymus cells.
Gene_expression (express) of CD26 in thymus
3) Confidence 0.61 Published 2003 Journal Life Sci. Section Abstract Doc Link 12738031 Disease Relevance 0 Pain Relevance 0.04
In this study we examined surface expression of CD26 and the corresponding enzyme activity of dipeptidyl peptidase IV (DPPIV) on the cells of immature murine T-cell line, R1.1.
Spec (examined) Gene_expression (expression) of CD26 in T-cell
4) Confidence 0.61 Published 2003 Journal Life Sci. Section Abstract Doc Link 12738031 Disease Relevance 0 Pain Relevance 0.04
In this study we examined surface expression of CD26 and the corresponding enzyme activity of dipeptidyl peptidase IV (DPPIV) on the cells of immature murine T-cell line, R1.1.
Spec (examined) Gene_expression (expression) of peptidase IV in T-cell
5) Confidence 0.46 Published 2003 Journal Life Sci. Section Abstract Doc Link 12738031 Disease Relevance 0 Pain Relevance 0.04
1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (M?
Gene_expression (activities) of peptidase IV in macrophages
6) Confidence 0.45 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.22
Together with PP and the dipeptidylpeptidase IV (DPP-IV)-cleaved products NPY(3-36) and PYY(3-36) (Mentlein et al., 1993), NPY and PYY exert a range of inhibitory activities, such as slowing gastric emptying, reducing intestinal anion and electrolyte secretion (Playford et al., 1990; Cox and Tough, 2002), and slowing intestinal motility, which collectively promote nutrient absorption.
Gene_expression (products) of dipeptidylpeptidase IV
7) Confidence 0.31 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.09
Together with PP and the dipeptidylpeptidase IV (DPP-IV)-cleaved products NPY(3-36) and PYY(3-36) (Mentlein et al., 1993), NPY and PYY exert a range of inhibitory activities, such as slowing gastric emptying, reducing intestinal anion and electrolyte secretion (Playford et al., 1990; Cox and Tough, 2002), and slowing intestinal motility, which collectively promote nutrient absorption.
Gene_expression (products) of DPP-IV
8) Confidence 0.31 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.09
Mucosal Gpr119 responses were not amplified by DPP-IV inhibition, indicating that degradation of full-length PYY to PYY(3-36) is not significant following Gpr119 activation in human or mouse colon mucosa.
Neg (inhibition) Gene_expression (inhibition) of DPP-IV in colon
9) Confidence 0.27 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0.08 Pain Relevance 0
The non-GI AEs associated with sitagliptin and vildagliptin may be related to the immunological properties of DPP-4, which is expressed in many tissues, and has numerous substrates, including GI hormones, neuropeptides, and cytokines.145 As DPP-4 is known to be involved in immunoregulation as a T-cell costimulator, and in breakdown of cytokines such as bradykinin and interleukin-2 and-1?
Gene_expression (expressed) of DPP-4 in T-cell associated with neuropeptide, bradykinin and cytokine
10) Confidence 0.27 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731024 Disease Relevance 1.28 Pain Relevance 0.25
The non-GI AEs associated with sitagliptin and vildagliptin may be related to the immunological properties of DPP-4, which is expressed in many tissues, and has numerous substrates, including GI hormones, neuropeptides, and cytokines.145 As DPP-4 is known to be involved in immunoregulation as a T-cell costimulator, and in breakdown of cytokines such as bradykinin and interleukin-2 and-1?
Gene_expression (properties) of DPP-4 in T-cell associated with neuropeptide, bradykinin and cytokine
11) Confidence 0.23 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731024 Disease Relevance 1.29 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox