INT101634

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 0.69
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LPAR1) cytoplasm (LPAR1) signal transducer activity (LPAR1)
Anatomy Link Frequency
NG108-15 1
cerebral cortex 1
LPAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 5 98.32 Very High Very High Very High
Enkephalin 4 88.36 High High
Somatostatin 9 75.00 Quite High
opioid receptor 3 75.00 Quite High
Cannabinoid receptor 1 66.16 Quite High
Peripheral nervous system 2 64.16 Quite High
Neurotransmitter 6 46.64 Quite Low
agonist 121 46.16 Quite Low
Dopamine 13 40.32 Quite Low
Multiple sclerosis 4 39.12 Quite Low
Disease Link Frequency Relevance Heat
Shock 10 93.04 High High
Neuroblastoma 2 91.00 High High
Stress 6 88.12 High High
Targeted Disruption 30 85.68 High High
Nervous System Injury 7 57.04 Quite High
Demyelinating Disease 8 39.12 Quite Low
Autoimmune Disease 4 34.52 Quite Low
Thyroiditis 2 21.96 Low Low
Systemic Lupus Erythematosus 2 17.60 Low Low
Coronary Artery Disease 2 15.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In NIE-115 and NG108-15 cells, and B103 cells expressing either LPA1 or LPA4, LPA causes a rapid, transient rounding which initiates at 5 minutes following LPA addition, and cells recover their flattened morphology after 20 minutes, even in the continued presence of LPA [21,44].
Gene_expression (expressing) of LPA1 in NG108-15
1) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.15 Pain Relevance 0
We further determined the fold change in transcript expression of LPA1, 2, 4, and 5 and S1P 1, 2, 3, and 5 in hES-NEP cells relative to their expression in the parent ES cell line WA09.
Gene_expression (expression) of LPA1
2) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
LPA1 receptor transcript expression was increased approximately ten fold while LPA2 expression was decreased approximately five fold in cumulative data representing three experiments, but these changes did not meet criteria for statistical significance.
Gene_expression (expression) of LPA1 receptor
3) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
Similarly, in B103 cells expressing exogenous LPA4, but not LPA1, LPA stimulated a slow aggregation that peaked at three hours [44].
Neg (not) Gene_expression (expressing) of LPA1
4) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.12 Pain Relevance 0
Cross-phosphorylation and cross-desensitization of the sst(2A)-MOR1 heterodimer were selective; they were neither observed with the sst(2A)-sst(3) heterodimer nor with the endogenously expressed lysophosphatidic acid receptor.
Gene_expression (expressed) of lysophosphatidic acid receptor
5) Confidence 0.31 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.22
LPA1 receptor signaling was only marginally affected with 0.05 mM GSNO, but was severely blunted with 0.2 mM GSNO and higher concentrations (Figure 2, Supplementary Figure 1 [see additional file 1]).
Gene_expression (blunted) of LPA1 receptor
6) Confidence 0.29 Published 2005 Journal BMC Cell Biol Section Body Doc Link PMC1090567 Disease Relevance 0 Pain Relevance 0
When equimolar concentrations (0.5 mM) of GSNO and SNAP were compared, SNAP equally well suppressed P2Y12 receptor responses, whereas GSNO more efficiently modulated M2/M4 and LPA1 receptor responses (Supplementary Figure 3 [see additional file 1]).
Gene_expression (modulated) of LPA1 receptor
7) Confidence 0.29 Published 2005 Journal BMC Cell Biol Section Body Doc Link PMC1090567 Disease Relevance 0 Pain Relevance 0
GPR4 and GPR68 both bind SPC, like the EDG receptor branch consisting of the EDG1, 3, 6 and 8 receptors in A13, but are not closely related.
Gene_expression (branch) of EDG receptor
8) Confidence 0.10 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.03
The first lysophosphatidic acid (LPA) receptor gene identified was the “ventricular zone gene-1 (vzg-1/LPA1)”, which was abundantly expressed in the ventricular zone of the embryonic cerebral cortex [3].
Gene_expression (expressed) of vzg-1 in cerebral cortex associated with cerebral cortex
9) Confidence 0.03 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0.15 Pain Relevance 0.08
Although a practical issue, it is important to note that heterologous expression of the non-EDG family receptors is often difficult and requires special plasmids and/or receptor-G protein fusion constructs (Noguchi et al., 2003; Tabata et al., 2007; Murakami et al., 2008).
Gene_expression (expression) of EDG
10) Confidence 0.03 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.27 Pain Relevance 0
Functional expression of LPAR of the purinergic subcluster often requires plasmids with strong promoters such as pCXN2.1 (Niwa et al., 1991) and/or co-expression of promiscuous G protein ?
Gene_expression (expression) of LPAR
11) Confidence 0.03 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0

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