INT101653

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 7.00
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SAA1)
Anatomy Link Frequency
blood 1
SAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 26 97.16 Very High Very High Very High
Inflammation 216 95.64 Very High Very High Very High
cytokine 65 88.24 High High
Pain 13 70.64 Quite High
depression 3 41.84 Quite Low
Fibrositis 1 40.88 Quite Low
Arthritis 7 39.76 Quite Low
interstitial cystitis 1 38.88 Quite Low
anakinra 38 27.68 Quite Low
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 63 99.30 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 99.30 Very High Very High Very High
Obesity 486 98.60 Very High Very High Very High
Myocardial Infarction 9 97.04 Very High Very High Very High
Stroke 9 96.32 Very High Very High Very High
INFLAMMATION 225 95.64 Very High Very High Very High
Deafness 8 91.08 High High
Body Weight 10 89.24 High High
Diabetes Mellitus 22 85.40 High High
Cancer 11 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The improvement in daily scores was accompanied by decreases in ESR, CRP and SAA levels.
Negative_regulation (decreases) of SAA
1) Confidence 0.39 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.52 Pain Relevance 0.11
Dietary SAA analysis and protein supplementation may be indicated for vegan athletes, children, or patients with HIV, because of an increased risk for SAA deficiency in these groups.
Negative_regulation (deficiency) of SAA associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.37 Published 2002 Journal Altern Med Rev Section Abstract Doc Link 11896744 Disease Relevance 0.50 Pain Relevance 0.06
Serum A-SAA levels decreased significantly after weight loss in obese participants (

p = 0.006), as well as in those treated with rosiglitazone ( p = 0.033).

Negative_regulation (decreased) of SAA associated with weight loss and obesity
3) Confidence 0.34 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 1.86 Pain Relevance 0.24
The authors speculate that drugs that reduce the blood levels of A-SAA might be useful as treatments for obese patients (to lower their risk of heart attacks and strokes).
Negative_regulation (reduce) of SAA in blood associated with stroke, obesity and myocardial infarction
4) Confidence 0.34 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 1.71 Pain Relevance 0.24
The magnitude of the improvement in insulin sensitivity after weight loss was significantly correlated with decreases in serum A-SAA (

r = ?

Negative_regulation (decreases) of SAA associated with weight loss
5) Confidence 0.34 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 1.97 Pain Relevance 0.27
Also a column is included, in which the available SAA are reduced by 0.9 g/day, equivalent to a SAA loss associated with the intake of the standard higher recommended dose of acetaminophen.
Negative_regulation (loss) of SAA associated with paracetamol
6) Confidence 0.34 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0 Pain Relevance 0.16
Also a column is included, in which the available SAA are reduced by 0.9 g/day, equivalent to a SAA loss associated with the intake of the standard higher recommended dose of acetaminophen.
Negative_regulation (reduced) of SAA associated with paracetamol
7) Confidence 0.34 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0 Pain Relevance 0.15
At the higher doses, a statistically significant improvement was seen in the reduction of the ESR (p < 0.05), and a trend towards further improvement in CRP and SAA level reduction.
Negative_regulation (reduction) of SAA
8) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.43 Pain Relevance 0.09

General Comments

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