INT10166

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Context Info
Confidence 0.81
First Reported 1990
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 237
Total Number 240
Disease Relevance 153.95
Pain Relevance 88.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
macrophages 13
mast cells 10
Kupffer cells 8
neuronal 8
hepatocyte 7
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 739 100.00 Very High Very High Very High
cytokine 543 100.00 Very High Very High Very High
anesthesia 84 100.00 Very High Very High Very High
c fibre 78 100.00 Very High Very High Very High
antagonist 71 100.00 Very High Very High Very High
Inflammatory mediators 63 100.00 Very High Very High Very High
Glutamate 41 100.00 Very High Very High Very High
substance P 28 100.00 Very High Very High Very High
neuralgia 14 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 871 100.00 Very High Very High Very High
Cancer 421 100.00 Very High Very High Very High
Necrosis 311 100.00 Very High Very High Very High
Neuropathic Pain 171 99.96 Very High Very High Very High
Hyperalgesia 63 99.96 Very High Very High Very High
Post Operative Pain 2 99.96 Very High Very High Very High
Arthritis 43 99.94 Very High Very High Very High
Diabetes Mellitus 369 99.92 Very High Very High Very High
Stress 109 99.92 Very High Very High Very High
Headache 18 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor necrosis factor-alpha release in explant medium increased from 0.02 +/- 0.03 pg/mg in 6 controls to 0.28 +/- 0.15 pg/mg in 14 animals after treatment with protamine sulfate/lipopolysaccharide and it decreased to 0.12 +/- 0.11 pg/mg in 10 animals pretreated with nanocrystalline silver (p = 0.009).
Localization (release) of Tumor necrosis factor-alpha
1) Confidence 0.81 Published 2008 Journal J. Urol. Section Body Doc Link 18295255 Disease Relevance 0.06 Pain Relevance 0
A relation between these positive effects and the TNF-alpha secretion by macrophages is discussed.
Localization (secretion) of TNF-alpha in macrophages
2) Confidence 0.81 Published 2003 Journal Eksp Klin Farmakol Section Abstract Doc Link 12683084 Disease Relevance 0.31 Pain Relevance 0.45
In behavioural experiments the influence of chronic intrathecally applied minocycline - a specific microglia inhibitor - or an antibody against tumour necrosis factor-alpha (TNF-alpha; a cytokine released from microglia) on pain-related behaviour was investigated after 1, 3, 6, and 12 days.
Localization (released) of TNF-alpha in microglia associated with pain, necrosis, cancer and cytokine
3) Confidence 0.81 Published 2009 Journal Eur J Pain Section Abstract Doc Link 19095475 Disease Relevance 1.06 Pain Relevance 0.74
We observed a dose-dependent decrease of TNF-alpha mRNA in the hepatocytes, and of TNF-alpha release into the medium of hepatocyte cultures.
Localization (release) of TNF-alpha in hepatocyte
4) Confidence 0.81 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.22 Pain Relevance 0.48
The data also indicate an impairment of TNF-alpha release in Kupffer cell cultures after treatment with nontoxic, as well as with toxic, acetaminophen concentrations.
Localization (release) of TNF-alpha in Kupffer cell associated with paracetamol
5) Confidence 0.81 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.21 Pain Relevance 0.50
However, bismuth had no effect on the viability on testicular macrophages at 50 microM up to 8 h, therefore, we studied the secretion of tumor necrosis factor alpha (TNF-alpha) after 4 h of exposure to 50 microM bismuth and found no influence on the production of TNF-alpha.
Localization (secretion) of TNF-alpha in macrophages associated with necrosis and cancer
6) Confidence 0.81 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15856528 Disease Relevance 0.35 Pain Relevance 0
This study reports on the immunocytochemical localization of tumor necrosis factor-alpha (TNF alpha) in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system (PNS) using teased nerve fiber preparations.
Localization (localization) of tumor necrosis factor-alpha in nerve associated with necrosis, demyelination, peripheral nervous system, cancer and wallerian degeneration
7) Confidence 0.80 Published 1993 Journal J. Neuroimmunol. Section Abstract Doc Link 8331160 Disease Relevance 1.25 Pain Relevance 0.34
This study reports on the immunocytochemical localization of tumor necrosis factor-alpha (TNF alpha) in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system (PNS) using teased nerve fiber preparations.
Localization (localization) of TNF alpha in nerve associated with necrosis, demyelination, peripheral nervous system, cancer and wallerian degeneration
8) Confidence 0.80 Published 1993 Journal J. Neuroimmunol. Section Abstract Doc Link 8331160 Disease Relevance 1.26 Pain Relevance 0.35
The results indicate that both NE and clonidine increased TNF-alpha release by approximately 4-7-fold in the isolated cultured Kupffer cells.
Localization (release) of TNF-alpha in Kupffer cells associated with clonidine
9) Confidence 0.80 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.28 Pain Relevance 0.28
Therefore, hemorrhage followed by retransfusion causes marked coronary vasoconstriction assessed ex vivo owing to the release of ET by factors including TNF-alpha.
Localization (release) of TNF-alpha associated with cva and increased venous pressure under development
10) Confidence 0.80 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8587433 Disease Relevance 0.68 Pain Relevance 0.25
Aspirin ingestion impairs oral mucosal ulcer healing by inducing membrane-bound tumor necrosis factor-alpha release.
Localization (release) of tumor necrosis factor-alpha associated with aspirin, necrosis, cancer and ulcers
11) Confidence 0.80 Published 2000 Journal IUBMB Life Section Title Doc Link 11327313 Disease Relevance 1.18 Pain Relevance 0.47
We conclude that urethan or its metabolites protect against LPS, in part, by reducing TNF-alpha release and speculate that this may be mediated by alpha 2-adrenoceptors.
Localization (release) of TNF-alpha
12) Confidence 0.80 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8941558 Disease Relevance 0.60 Pain Relevance 0.11
Urethan anesthesia protects rats against lethal endotoxemia and reduces TNF-alpha release.
Localization (release) of TNF-alpha associated with endotoxemia and anesthesia
13) Confidence 0.80 Published 1996 Journal J. Appl. Physiol. Section Title Doc Link 8941558 Disease Relevance 0.61 Pain Relevance 0.14
Staining for TNF alpha appears to be largely localized to neurons and neuronal processes, further substantiating the proposal that TNF alpha is either synthesized de novo or is accumulated in and released by neurons.
Localization (released) of TNF alpha in neuronal
14) Confidence 0.80 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9357451 Disease Relevance 0.26 Pain Relevance 0.49
TNF alpha localization in neurons and its modification of NE release comparable to alpha 2-adrenergic receptor activation, explains a functional role for the cytokine as a neuromodulator in the CNS.
Localization (localization) of TNF alpha in CNS associated with central nervous system and cytokine
15) Confidence 0.80 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9357451 Disease Relevance 0.15 Pain Relevance 0.41
TNF-alpha expression and glial cell reactions in the DRG and spinal cord play an important role in the neuropathic pain state, and TNF-alpha is released from glial cells in the nervous system.
Localization (released) of TNF-alpha in nervous system
16) Confidence 0.79 Published 2008 Journal Spine Section Body Doc Link 18496347 Disease Relevance 0.14 Pain Relevance 0
TNFalpha cytotoxicity on gastric mucosal cells was examined by treating rats with lipopolysaccharide to release TNFalpha or by incubating dispersed gastric mucosal cells with increasing concentrations of TNFalpha.
Localization (release) of TNFalpha
17) Confidence 0.79 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.07 Pain Relevance 0
BACKGROUND: Although previous studies indicate that prevention of tumour necrosis factor alpha (TNFalpha) release protects against NSAID-induced gastric mucosal injury, intracellular pathways by which aspirin causes TNFalpha release are unknown.
Localization (release) of TNFalpha associated with aspirin, necrosis, cancer, injury and cinod
18) Confidence 0.79 Published 1998 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 9845404 Disease Relevance 0.37 Pain Relevance 0.23
AIM: To investigate: (i) molecular events that regulate TNFalpha secretion in response to aspirin in vivo and in vitro; (ii) whether TNFalpha secretion inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal damage; and (iii) whether TNFalpha exerts a direct cytotoxic effect on gastric epithelial cells.
Localization (secretion) of TNFalpha in epithelial cells
19) Confidence 0.79 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.10 Pain Relevance 0
AIM: To investigate: (i) molecular events that regulate TNFalpha secretion in response to aspirin in vivo and in vitro; (ii) whether TNFalpha secretion inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal damage; and (iii) whether TNFalpha exerts a direct cytotoxic effect on gastric epithelial cells.
Localization (secretion) of TNFalpha in epithelial cells
20) Confidence 0.79 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.09 Pain Relevance 0

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