INT10167

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Context Info
Confidence 0.77
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 8.38
Pain Relevance 4.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ns5atp9) nucleus (Ns5atp9)
Anatomy Link Frequency
plasma 2
platelet 2
neutrophils 2
brain 1
alveolar macrophages 1
Ns5atp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 90 100.00 Very High Very High Very High
Inflammation 89 100.00 Very High Very High Very High
Eae 4 99.20 Very High Very High Very High
bradykinin 12 99.10 Very High Very High Very High
Neurotransmitter 2 98.44 Very High Very High Very High
Pain 7 97.00 Very High Very High Very High
Chronic pancreatitis 6 95.36 Very High Very High Very High
Nicotine 11 93.84 High High
Inflammatory response 7 93.24 High High
cytokine 10 92.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 96 100.00 Very High Very High Very High
Nicotine Addiction 16 99.78 Very High Very High Very High
Adhesions 43 99.62 Very High Very High Very High
Pancreatitis 11 98.68 Very High Very High Very High
Leukopenia 1 98.36 Very High Very High Very High
Nociception 13 98.28 Very High Very High Very High
Pain 4 97.00 Very High Very High Very High
Diabetes Mellitus 9 94.24 High High
Necrosis 10 92.20 High High
Cancer 8 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A variety of stimuli, including those producing inflammation, promote the synthesis and release of PAF from various cell types.
Gene_expression (synthesis) of PAF associated with inflammation
1) Confidence 0.77 Published 2002 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 12373444 Disease Relevance 0.25 Pain Relevance 0.12
Pancreatic production of lipid mediators of inflammation, including eicosanoids and platelet-activating factor (PAF), was examined in two models of pancreatitis in the rat.
Spec (examined) Gene_expression (production) of PAF in platelet associated with inflammation and pancreatitis
2) Confidence 0.73 Published 1994 Journal J. Surg. Res. Section Abstract Doc Link 8277767 Disease Relevance 0.59 Pain Relevance 0.33
Using the biphasic formalin model in rats, we recently demonstrated that PAF antagonists which were selective for either intracellular or plasma membrane PAF receptors decreased the late-phase of the nociceptive response.
Gene_expression (selective) of PAF in plasma associated with nociception, antagonist and eae
3) Confidence 0.67 Published 2006 Journal Brain Res. Section Abstract Doc Link 16774744 Disease Relevance 0.64 Pain Relevance 0.50
Using the biphasic formalin model in rats, we recently demonstrated that PAF antagonists which were selective for either intracellular or plasma membrane PAF receptors decreased the late-phase of the nociceptive response.
Gene_expression (selective) of PAF in plasma associated with nociception, antagonist and eae
4) Confidence 0.67 Published 2006 Journal Brain Res. Section Abstract Doc Link 16774744 Disease Relevance 0.63 Pain Relevance 0.49
Thus, PAF induces a vasorelaxation by releasing EDRF from endothelial cells as ACh does, although the pathway to produce the substances by PAF may be different from that by ACh.
Gene_expression (produce) of PAF in endothelial cells
5) Confidence 0.64 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2314485 Disease Relevance 0.06 Pain Relevance 0.10
In perfused mesenteric arterial bed preconstricted with methoxamine (10(-5) - 10(-4) M), PAF (10(-11) -3 x 10(-10) M) produced a concentration-dependent relaxation.
Gene_expression (produced) of PAF
6) Confidence 0.60 Published 1991 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 1783976 Disease Relevance 0.73 Pain Relevance 0
The naturally occurring phospholipid mediator PAF (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is produced by a variety of inflammatory cells including neutrophils, alveolar macrophages, mast cells, eosinophils, and others.
Gene_expression (produced) of PAF in eosinophils associated with inflammation
7) Confidence 0.60 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2278150 Disease Relevance 0.28 Pain Relevance 0.37
This circuit inhibits sympathetic neuron-dependent plasma extravasation (PE) in the rat knee joint produced by bradykinin (BK), but not sympathetic neuron-independent PE produced by platelet activating factor (PAF).
Gene_expression (produced) of PAF in sympathetic associated with bradykinin
8) Confidence 0.36 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9862910 Disease Relevance 0.30 Pain Relevance 0.41
To investigate the interaction between PAF, TNF-alpha and myocardial depressant factor, the blood levels of these three mediators were evaluated: shocked rats exhibited increased PAF levels with a peak at 30 min.
Gene_expression (levels) of PAF in blood
9) Confidence 0.25 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1468489 Disease Relevance 0.71 Pain Relevance 0.04
The naturally occurring phospholipid mediator PAF (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is produced by a variety of inflammatory cells including neutrophils, alveolar macrophages, mast cells, eosinophils, and others.
Gene_expression (produced) of PAF in mast cells associated with inflammation
10) Confidence 0.20 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2278150 Disease Relevance 0.28 Pain Relevance 0.37
The naturally occurring phospholipid mediator PAF (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is produced by a variety of inflammatory cells including neutrophils, alveolar macrophages, mast cells, eosinophils, and others.
Gene_expression (produced) of PAF in alveolar macrophages associated with inflammation
11) Confidence 0.20 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2278150 Disease Relevance 0.28 Pain Relevance 0.37
The naturally occurring phospholipid mediator PAF (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is produced by a variety of inflammatory cells including neutrophils, alveolar macrophages, mast cells, eosinophils, and others.
Gene_expression (produced) of PAF in neutrophils associated with inflammation
12) Confidence 0.20 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2278150 Disease Relevance 0.28 Pain Relevance 0.37
Smoking increases production of platelet activating factor (PAF) and endothelin, which are potent gastric ulcerogens.
Gene_expression (production) of PAF in platelet associated with nicotine addiction
13) Confidence 0.13 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.34 Pain Relevance 0.53
PAF can be synthesized in neurons following stimulation with neurotransmitters such as N-methyl-d-aspartic acid (NMDA) and glutamic acid and plays various roles in neuronal functions and brain development [68].
Gene_expression (synthesized) of PAF in neurons associated with neurotransmitter
14) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 1.09 Pain Relevance 0.49
BN-52021 could also reduce PAF-induced production of the eicosanoid and thromboxane B in a fetal rat brain [4,71].
Gene_expression (production) of PAF in brain
15) Confidence 0.07 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.70 Pain Relevance 0.35
Neutrophil adhesion, performed in the presence of PAF (10-9 M), was allowed to proceed for 30 and 60 min at 37°C.
Gene_expression (presence) of PAF in Neutrophil associated with adhesions
16) Confidence 0.07 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.19 Pain Relevance 0
Stimulants and concentrations used, which were optimized in preliminary experiments, were: PAF (10-9M), IL-8 (10-9M), TNF (5 ng/mL), or LTB4(10-9M).


Gene_expression (10-9M) of PAF
17) Confidence 0.06 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0 Pain Relevance 0.04

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