INT10168

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Context Info
Confidence 0.60
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 3.55
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
heart 6
nucleus 4
hypothalamus 3
smooth muscle 2
fibroblast 2
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 12 100.00 Very High Very High Very High
Locus ceruleus 8 100.00 Very High Very High Very High
Dopamine 2 99.90 Very High Very High Very High
Cannabinoid 8 99.68 Very High Very High Very High
Neuropeptide 3 99.60 Very High Very High Very High
Enkephalin 2 99.56 Very High Very High Very High
Morphine 1 98.72 Very High Very High Very High
dexamethasone 2 98.46 Very High Very High Very High
substance P 5 98.42 Very High Very High Very High
intrathecal 2 97.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 4 100.00 Very High Very High Very High
Shock 5 99.36 Very High Very High Very High
Pressure And Volume Under Development 1 98.00 Very High Very High Very High
Appetite Loss 4 97.92 Very High Very High Very High
Stress 8 96.84 Very High Very High Very High
Hyperalgesia 2 95.40 Very High Very High Very High
Drug Dependence 2 91.92 High High
Body Weight 5 91.20 High High
Spinal Cord Injury 24 79.24 Quite High
Leukopenia 1 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that intrathecal administration of substance P produces a neurally mediated increase in arterial pressure and heart rate and induces the release of an adrenal opioid factor which slows the neurally-mediated cardioacceleration by an action in the periphery.
Positive_regulation (induces) of Localization (release) of factor in heart associated with opioid, substance p and intrathecal
1) Confidence 0.60 Published 1993 Journal Neuropeptides Section Abstract Doc Link 7510372 Disease Relevance 0.05 Pain Relevance 0.77
Prostaglandin E2 is a metabotropic transmitter, activating adenylate cyclase, either directly or through the release of a stimulatory protein factor.
Positive_regulation (activating) of Localization (release) of factor
2) Confidence 0.15 Published 1981 Journal Agents Actions Section Abstract Doc Link 6280466 Disease Relevance 0.36 Pain Relevance 0.35
Release of atrial natriuretic factor (ANF) following an elevation in heart rate is thought to be mediated primarily by a change in atrial stretch.
Positive_regulation (mediated) of Localization (Release) of factor in heart associated with natriuresis
3) Confidence 0.15 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2522835 Disease Relevance 0.17 Pain Relevance 0
Release of atrial natriuretic factor (ANF) following an elevation in heart rate is thought to be mediated primarily by a change in atrial stretch.
Positive_regulation (elevation) of Localization (Release) of factor in heart associated with natriuresis
4) Confidence 0.11 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2522835 Disease Relevance 0.17 Pain Relevance 0
Inhibition by antiserum to rat growth hormone-releasing factor of growth hormone secretion induced by a met5-enkephalin analog, FK33-824, in rats.
Positive_regulation (induced) of Localization (secretion) of factor associated with enkephalin
5) Confidence 0.10 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Title Doc Link 3917569 Disease Relevance 0 Pain Relevance 0.32
At a central level increased activity in the noradrenergic locus coeruleus (LC) and an enhanced secretion of corticotrophin-releasing factor (CRF) and vasopressin produced in the paraventricular nucleus (PVN) integrate stress response.
Positive_regulation (increased) of Localization (secretion) of factor in nucleus associated with stress and locus ceruleus
6) Confidence 0.10 Published 1997 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 9401603 Disease Relevance 0.24 Pain Relevance 0.08
At a central level increased activity in the noradrenergic locus coeruleus (LC) and an enhanced secretion of corticotrophin-releasing factor (CRF) and vasopressin produced in the paraventricular nucleus (PVN) integrate stress response.
Positive_regulation (enhanced) of Localization (secretion) of factor in nucleus associated with stress and locus ceruleus
7) Confidence 0.10 Published 1997 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 9401603 Disease Relevance 0.24 Pain Relevance 0.08
These results suggest that: (1) the presence of oestrogen or androgen increases the contraction caused by alpha2-adrenoceptor activation with clonidine; (2) endothelium negatively modulates the response to this agonist in the four groups of rats, due to endothelial NO release (entirely in females and in part in males); (3) androgen also seems to modulate the response by stimulating the release of an endothelial contracting factor, probably a prostanoid; and (4) the endothelium of males has a greater capacity than that of comparable females for negative regulation of the tension generated by the underlying vascular smooth muscle.
Positive_regulation (stimulating) of Localization (release) of factor in smooth muscle associated with agonist and clonidine
8) Confidence 0.09 Published 1999 Journal Clin. Sci. Section Abstract Doc Link 10369790 Disease Relevance 0 Pain Relevance 0.31
Melanocortins seem to play an important role in stress-induced anorexia, because such condition, in rats, is significantly attenuated by the blockage of melanocortin MC(4) receptors; such a role is not secondary to an increased release of corticotropin-releasing factor (CRF), because, on the other hand, the CRF-induced anorexia is not affected at all by the blockage of melanocortin MC(4) receptors.
Positive_regulation (increased) of Localization (release) of factor associated with appetite loss and stress
9) Confidence 0.09 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11033311 Disease Relevance 0.94 Pain Relevance 0.15
The effects of N6-cyclohexyladenosine (0.1 mg/kg) and L-N6-phenylisopropyladenosine (0.1 mg/kg) were completely blocked in animals pretreated with dexamethasone (3 x 1 mg/kg), as well as in animals with a pharmacological blockade of the release of hypothalamic corticotropin-releasing factor induced by chloropromazine (10 mg/kg), morphine (20 mg/kg) and nembutal (25 mg/kg), whereas the corticosterone response to 5'-N-ethylcarboxamidoadenosine (0.01 mg/kg) was blocked in dexamethasone-pretreated rats only.
Positive_regulation (induced) of Localization (release) of factor associated with dexamethasone and morphine
10) Confidence 0.08 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1471459 Disease Relevance 0 Pain Relevance 0.35
These results revealed that chronic cannabinoid administration enhances corticotropin releasing factor and proopiomelanocortin gene expression in the hypothalamus and anterior pituitary, a process that may be considered as part of a molecular integrative response to the stress associated to cannabinoid drug abuse.
Positive_regulation (enhances) of Localization (releasing) of factor in hypothalamus associated with stress, drug abuse and cannabinoid
11) Confidence 0.07 Published 1999 Journal Life Sci. Section Abstract Doc Link 10201639 Disease Relevance 0.19 Pain Relevance 0.30
The results of this study therefore suggest that PAF is a key mediator of splanchnic artery occlusion shock and plays a permissive role in inducing the release of other factors (i.e.
Positive_regulation (inducing) of Localization (release) of factor in artery associated with shock
12) Confidence 0.06 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1468489 Disease Relevance 0.55 Pain Relevance 0.03
Furthermore, sections through the rostral dorsal pons, from colchicine-treated rats, were processed for EM-1 and corticotropin releasing factor (CRF), a neuropeptide known to be present in neurons of Barrington's nucleus.
Positive_regulation (processed) of Localization (releasing) of factor in Barrington's nucleus associated with neuropeptide
13) Confidence 0.04 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 12115708 Disease Relevance 0 Pain Relevance 0.52
The proestrous surge of PRL could result from a decrease in dopamine, an increase in PRL-releasing factor (PRF) or both.
Positive_regulation (increase) of Localization (releasing) of factor associated with dopamine
14) Confidence 0.04 Published 1989 Journal Endocrinology Section Abstract Doc Link 2492217 Disease Relevance 0.08 Pain Relevance 0.12
These results revealed that chronic cannabinoid administration enhances corticotropin releasing factor and proopiomelanocortin gene expression in the hypothalamus and anterior pituitary, a process that may be considered as part of a molecular integrative response to the stress associated to cannabinoid drug abuse.
Positive_regulation (enhances) of in anterior pituitary Localization (releasing) of factor in hypothalamus associated with stress, drug abuse and cannabinoid
15) Confidence 0.02 Published 1999 Journal Life Sci. Section Abstract Doc Link 10201639 Disease Relevance 0.19 Pain Relevance 0.30
For example, it stimulates proliferation of a variety of cells in culture [25, 28] and promotes synthesis and release of several potentially neuroprotective trophic factors from a variety of cells, including neuron growth factor (NGF) from astrocytes as well as basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) [25, 27].
Positive_regulation (promotes) of Localization (release) of factor in fibroblast
16) Confidence 0.02 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2246001 Disease Relevance 0.36 Pain Relevance 0.08

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